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A Review on L-Asparaginase
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Numerous applications have been derived directly from enzymes because of their pharmaceutical properties. There are enzymes that have therapeutic uses, including L-arginase (antitumor); L-asparaginase (antitumor), L-tyrosinase (antitumor), L-glutaminase (antitumor), uricase (gout), urokinase (blood clots), glucosidase (antitumor), lysozyme (antibiotic), trypsin (inflammation), urokinase (anticoagulant), ribonuclease (antiviral), rhodanase (cyanide poisoning), hyaluronidase (heart attack), serratiopeptidase (anti-inflammatory), β-lactamase (penicillin allergy), dornase α (cystic fibrosis), collagenase (skin ulcers), streptokinase (anticoagulant), laccase (detoxifier), lipase (digest lipids), rasburicase (hyperuricemia), sacrosidase (congenital sucraseisomaltase deficiency) and peptidase (celiac disease). Currently, enzyme replacement therapy has been permitted for six lysosomal storage diseases, and rDNA human enzymes are under clinical trials (Kaur et al., 2012).
Assessment of pain and maternal complications after normal vaginal delivery
Published in Journal of Obstetrics and Gynaecology, 2022
Srinidhi RS, Sherwin Keith D’lima, Uday Venkat Mateti, Shipra Sonkusare
In contrast, a contradicting result was shown by a study directed by Iyengar (2012), where the occurrence of breast problems was less than 10%. In 43.5% of the participants in the study carried out by Brown and Lumley (1998) proved similar results that the majority of the subjects in our study experienced pain during walking on Day 1 and Day 2. In contrast, in a study conducted by Stainton et al. (1999), most subjects experienced pain. In contrast, both breastfeeding and nipple pain on Day 1 and Day 2 contradicted our study (Stainton et al. 1999). In this study, 296 (98.66%) subjects were given a combination of diclofenac and serratiopeptidase. A conflicting result was obtained in which 237 women were given either Ibuprofen or Acetaminophen orally (Peter et al. 2001). Oral administration of NSAIDs and Analgesics were the primary treatment given for postpartum perineal pain relief in this study. The same treatment was shown in a study conducted by Francisco et al. (2011). Pharmacological management given to participants proved to be very effective. In this study, 100% experienced postpartum haemorrhage. In contrast, contradictory results were found in studies conducted by Fukami et al. (2019) and Brown and Lumley (1998), where postpartum haemorrhage was 8.7% and 6.3%, respectively.
Amelioration of Bleomycin and Methotrexate-Induced Pulmonary Toxicity by Serratiopeptidase and Fisetin
Published in Nutrition and Cancer, 2021
Muhammad Shahbaz, Sairah Hafeez Kamran, Rukhsana Anwar
The basic principle lying in the chemoprotection is to minimize the toxicity of drug under evaluation. Numerous results from various sources suggest the addition of chemoprotective agents during chemotherapy bring betterment to daily routine of life as they enhance the drug tolerability and surprisingly lessen the adverse effects (1). A chemoprotectant can be from a natural or plant source like fisetin (FST), a falvonoid, which is a powerful antioxidant (7), or can be from a nonpathogenic microorganism like serratiopeptidase (SPTD), a proteolytic enzyme, obtained from enterobacterium Serratia sp. E15 from silkworm (8), or can be from a synthetic source for example N- acetylcysteine, which is synthetic N-acetyl derivative of the endogenous amino acid L-cysteine, an originator of the antioxidant enzyme glutathione (9).
The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation
Published in Journal of Drug Targeting, 2018
Chun Y. Wong, Hani Al-Salami, Crispin R. Dass
Chitosan-based nanoparticles can be an efficient delivery system to deliver proteolytic enzymes for therapeutic use. Serratiopeptidase (SER) is an extracellular proteolytic enzyme that can be used to suppress inflammation, reduce oedema and manage pain [86]. It contains 450 amino acid groups and it is temperature, moisture and pH sensitive. Therefore, encapsulation of SER in chitosan-based nanoparticles would be an effective approach for oral delivery of a sensitive peptide [57]. In this study, it was found that an increase in TPP concentration was associated with smaller nanoparticle size and higher entrapment efficiency (75.8%). In the meantime, the SER-loaded nanoparticles showed prolonged anti-inflammatory effect in the left hind paw of the rats. However, further studies in terms of toxicology and pharmacology are required for clinical utility of the formulation.