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Cognition Enhancers
Published in Sahab Uddin, Rashid Mamunur, Advances in Neuropharmacology, 2020
Ramneek Kaur, Rashi Rajput, Sachin Kumar, Harleen Kaur, R. Rachana, Manisha Singh
The fact that D-serine and glycine seem to have same effect on NMDA receptor functioning that has made the recognition of endogenous ligands (for GluN1 site) intricate. The consequences of D-serine and glycine on synaptic plasticity are converted into cognitive function. Therefore, by inhibiting the formation of D-serine by knocking out serine racemase inhibits the memory that is restored by treatment with D-serine (Balu et al., 2013).
Organic Chemicals
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017
William J. Rea, Kalpana D. Patel
d-Serine has also been found to coagonize the NMDA receptor with even greater potency than glycine.24d-Serine is produced by serine racemase, and is enriched in the same areas as NMDA receptors. Removal of d-serine can block NMDA-mediated excitatory neurotransmission in many areas. Recently, it has been shown that d-serine can be released by neurons and astrocytes to regulate NMDA receptors.
Predictive value of serum d -serine level for hearing impairment in uremic patients
Published in Renal Failure, 2023
Jiaqing Li, Dunlu Yuan, Qing Yang, Jingjing Huang, Zhu Zhou, Ruomei Li, Qing Li
d-Serine is a non-essential amino acid and an enantiomer of l-serine, mainly distributed in the mammalian brain and retina under normal circumstances of low peripheral content. It regulates brain development, neuronal excitability, and synaptic plasticity, and plays a critical role in the central nervous system [12]. Serine racemase (SR) catalyzes the conversion of l-serine to d-serine, while d-amino acid oxidase (DAO) oxidizes and degrades d-serine [13,14]. d-Serine metabolic disorder leads to neurodegenerative diseases and may be involved in mental illness [15]. Some studies have shown that d-serine is nephrotoxic and damages the proximal renal tubules [16]; this feature can be used to evaluate the renal function as well as the early diagnosis and prognosis of CKD [17,18]. However, whether d-serine is related to HI in uremic patients is yet to be clarified. Therefore, the present study aimed to analyze the factors affecting HI and explore the expression of serum d-serine in the peripheral blood of uremic patients with HI and its predictive value. This would provide novel ideas for the clinical prevention and treatment of uremic patients with HI.
Elevated plasma levels of D-serine in some patients with amyotrophic lateral sclerosis
Published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2021
Aven Lee, Buddhika Jayakody Arachchige, Robert Henderson, David Pow, Sarah Reed, James Aylward, Pamela Ann McCombe
There have been prior studies using immune assays to quantify D-serine in the CNS of patients with ALS and animal models. There are reports of elevated D-serine in the ventral spinal cord in SOD1-G93A transgenic mice and ALS patients in which immunoreactivity to D-serine was shown to be accumulated in motor neurons and surrounding glial cells (8,17). Aside from entry from the circulation, there are other explanations for altered D-serine metabolism in ALS. Levels of D-serine and activities of serine racemase (SR) and D-amino acid oxidase (DAO) which are responsible for the synthesis and degradation of D-serine are known to be perturbed in spinal cord in ALS (18). Mutations in DAO are found in some patients with familial ALS (19). Cells with mutant DAO undergo altered autophagy (18). However, such genetic abnormalities are likely to be rare and unlikely to be the cause of alterations in excitotoxicity in the majority of ALS patients.
Intracerebroventricular infusion of D-serine decreases nociceptive behaviors induced by electrical stimulation of the dura mater of rat
Published in Neurological Research, 2019
xiaolin Wang, zhe Yu, zi He, qiang Zhang, shengyuan Yu
In spite of that the detail mechanism remains to be explored, we see the chance of the D-serine to be a prospective therapy in migraine through the present result. Fortunately, a recent research gives us more confidence in the hypothesis that the positive effect of D-serine in relieving the affective disease would be also obtained in the headache. In this research, great progress has been made through genome-wide association studies (GWAS) identifying the association between schizophrenia and migraines and showing that both conditions share common genetic factors, with inverse effects in the glutamatergic system and genes involved in NMDA activation. This association could be attributed to a single intronic variant, rs4523957, in the SRR-encoding enzyme serine-racemase, which limits the rate of D-serine synthesis [17]. Since the complement of D-serine is used to treat schizophrenia patients, whose D-serine levels are lower than normal, the same complement might prove to be an effective migraine treatment. We will test this hypothesis if low-level D-serine is proved in migraines serum and this is exactly what we are doing.