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Wearable Sensors for Blood Perfusion Monitoring in Patients with Diabetes Mellitus
Published in Andrey V. Dunaev, Valery V. Tuchin, Biomedical Photonics for Diabetes Research, 2023
Evgenii A. Zherebtsov, Elena V. Zharkikh, Yulia I. Loktionova, Angelina I. Zherebtsova, Viktor V. Sidorov, Alexander I. Krupatkin, Andrey V. Dunaev
One of the promising areas of application of novel wearable LDF devices in DM clinical care is the evaluation of the effectiveness of therapy for its complications. Antioxidant therapy is quite often used in the DM clinic, since one of the leading causes of complications is oxidative stress [70]. Antioxidant therapy has shown the ability to slow or prevent the development of diabetic complications in some cases [71]. The most commonly used substances include alpha-lipoic acid (ALA), which belongs to the series of strong antioxidants and has an insulin-like effect. ALA has been reported to have a number of potentially beneficial effects for both the prevention and treatment of diseases related to peroxidation.
Cardiovascular Risk Factors
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
A decrease in potassium and increase in sodium can have direct effects on available antioxidants and oxidation of lipids, especially within cell membranes. Both RAAS and SNS activity can increase free-radical generation, which further decreases available antioxidants and lipid peroxidation. Collectively, these steps create oxidative stress within the body.
Disorders in tHemostasis System and Changes in the Rheological Properties of the Blood in Ischemic Heart Disease and Diabetes Mellitus Patients
Published in E.I. Sokolov, Obesity and Diabetes Mellitus, 2020
Atherosclerotic disorders are also accompanied by qualitative changes in the membranes of the erythrocytes. The peroxidation syndrome was studied in experiments with animals [226]. In this process, the content of acylhydroperoxides in the blood serum increased, the resistance of the erythrocyte membranes to spontaneous hemolysis lowered, and the rate of accumulation of malonic dialdehyde in the liver tissue increased. A growth in the level of LDLP and VLDLP in the blood was noted, and a drop in the amount of prostacyclin in the aorta wall. The presence of lipid infiltration was discovered morphologically. Moreover, a growth in the sensitivity of the injured sections of the aorta to vasoactive substances — adrenaline and histamine — was established. Numerous studies showed the importance of the peroxidation syndrome in the development of atherosclerotic changes.
Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E
Published in Journal of Microencapsulation, 2023
Ran Tao, Qianyu Zhang, Jialing Duan, Ran Chen, Liyun Yao, Ruiteng Zhang, Gang Dong, Huali Chen
VC and VE worked together to play an antioxidant and synergistic effect (De la Fuente et al.2020, Jagdeo et al.2021, Puscion-Jakubik et al.2021). VC was effective in scavenging superoxide, hydroxyl, and peroxyl radicals. VE reacted at high speed with lipid peroxide radicals and interrupts the free radical chain, thus preventing further lipid peroxidation (Wefers and Sies 1988). Researchers had studied the interaction of vitamins C and E in the prevention of lipid peroxidation (Niki et al.1982). VC interacted with VE to obtain reactive VE, and they acted together in rats exposed to arsenic resulting in reduced levels of lipid peroxidation, protein carbonyl compounds, and hydrogen peroxide, and increased levels of reduced glutathione (Egel et al.2002, Frank et al.2003). This might be why VC and VE have potentiated antioxidant effects in the current study.
Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum) extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model
Published in Drug and Chemical Toxicology, 2023
Adedayo Oluwaseun Ademiluyi, Opeyemi Babatunde Ogunsuyi, Josephine Oluwaseun Akinduro, Olayemi Philemon Aro, Ganiyu Oboh
This study revealed that there was a significant increase in ROS (as quantified as H2O2 equivalent) content in Mn treated flies. However, the dietary inclusions of SL and WB leaves alkaloid extracts significantly prevented the elevation in ROS contents. One of the justifications for this observation could be as a result of the ability of dietary inclusions of SL and WB leaves to significantly reduce MAO activities in Mn treated flies as earlier discussed. Secondly, the antioxidant properties of SL and WB leaves could have also contributed to their abilities to reverse elevation in ROS content in Mn assaulted flies. Previous studies (Oboh et al. 2014, Ademiluyi et al. 2015) have shown that green leafy vegetables that are rich in antioxidant phytochemicals are capable of inhibiting lipid peroxidation chain reactions. Impairments in endogenous antioxidant defense systems such as catalase, glutathione (GSH), superoxide dismutase (SOD), and glutathione-S-transferase (GST) are possible consequences of oxidative stress. To further support the antioxidant properties of SL and WB extracts, it was also observed that there was increase in activities of catalase and GST in flies fed diets containing the extracts alone.
Occupational risk assessment of exposure to metals in chrome plating workers
Published in Drug and Chemical Toxicology, 2022
Cristina Deuner Muller, Solange Cristina Garcia, Natália Brucker, Gabriela Goethel, Elisa Sauer, Larissa Machado Lacerda, Evandro Oliveira, Thereza Luciano Trombini, Aline Belem Machado, Anelise Pressotto, Virginia Cielo Rech, Cláudia Regina Klauck, Luciano Basso da Silva, Adriana Gioda, Luciane Rosa Feksa
The present study aimed to evaluate the occupational risk of exposure to metals in chrome plating workers. For that, the inflammatory expression such as β-2 integrin, intercellular adhesion molecule-1 (ICAM-1), and L-selectin was determined in lymphocytes. The comet and micronucleus assays were used for detecting the possible genotoxic effects. Lipid peroxidation was assessed by malondialdehyde (MDA) levels, and protein oxidation was evaluated by the protein carbonyl (PCO) assay to determine the possible involvement of oxidative stress. The possible influences of confounding factors such as age, smoking, alcohol consumption, and exposure time were also analyzed. Therefore, this present study aimed to identify critical metabolic targets on occupational exposure to determine biomarkers of effect, assisting in the diagnosis and monitoring of workers of the chrome plating industry.