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Impact of Music Therapy on Complicated Grief Reactions in Elderly Persons
Published in Goh Cheng Soon, Gerard Bodeker, Kishan Kariippanon, Healthy Ageing in Asia, 2022
Schiele et al. (2018) for the first time suggests a gene–environment interaction effect of an oxytocin receptor gene variant with behavioural inhibition and possibly also symptoms of adult separation anxiety in the moderation of vulnerability for CG.
The diagnosis and management of preterm labor with intact membranes
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Roberto Romero, Tinnakorn Chaiworapongsa, Francesca Gotsch, Lami Yeo, Ichchha Madan, Sonia S. Hassan
Oxytocin is a powerful stimulant of myometrial contractions. Its receptor is widely distributed in myometrium and decidua. Atosiban, an oxytocin receptor antagonist, can block spontaneous and oxytocin-induced uterine contractility. This agent is used widely in Europe, but is not available in the United States.
The Limbic System, Oxytocin, and Pain Management
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
Sahar Swidan, Charles E. Schultz
Protein expression of inflammatory (COX-2, iNOS) and algesiogenic (nNOS) enzymes was evaluated in the spinal cord 3 hours post-carrageenan insult, and then again after the administration of icv oxytocin, to explore the effects of oxytocin on the inflammatory process. Carrageenan alone significantly increased the expression of COX-2, iNOS, and nNOS. Oxytocin administration significantly reduced nNOS expression but did not modify COX-2 or iNOS levels. Results were consistent with what was seen with the pain model, a reduction in pain but a lack of effect on edema. Direct involvement of the oxytocin receptor was confirmed using a specific receptor antagonist, which produced significant inhibition of oxytocin’s antihyperalgesic effects.
Novel oxytocin receptor antagonists for tocolysis: a systematic review and meta-analysis of the available data on the efficacy, safety, and tolerability of retosiban
Published in Current Medical Research and Opinion, 2021
Greg Marchand, Richard Blumrick, Alexandra D. Ruuska, Kelly Ware, Ahmed Taher Masoud, Alexa King, Stacy Ruther, Giovanna Brazil, Kaitlynne Cieminski, Nicolas Calteux, Hollie Ulibarri, Katelyn Sainz
As a result of all these complications, a constant search for effective medications to stop PTL is an important goal of obstetrics. The treatment of PTL relies on the inhibition of uterine contractions so labor can ideally be delayed for at least 48 h, a period sufficient to allow the pregnant woman to be transferred to a center specialized in the management of preterm deliveries, to administer corticosteroids to reduce neonatal organ immaturity, and to administer magnesium for neuroprotection32. Currently available tocolytic agents include nonsteroidal anti-inflammatory drugs, calcium channel blockers, β-agonists, and—outside the US—oxytocin antagonists33,34. Oxytocin is an important target in treatment options. It is a peptide hormone secreted from the hypothalamus and released by the posterior pituitary gland. It has many physiological functions; however, it is best known for its role in uterine contractions during parturition35. Thus, oxytocin receptor antagonism theoretically inhibits uterine contractions.
Oxytocinergic regulation in pathogenesis of pelvic pain caused by adenomyosis
Published in Gynecological Endocrinology, 2020
Mekan Orazov, Victor Radzinsky, Olga Sharapova, Igor Kostin, Yurii Chitanava
Among the secreted neuronal markers, oxytocin, which is a key factor regulating uterine contractility, must be identified. It should be noted that oxytocin directly stimulates the contraction of smooth myocytes of the myometrium and its blood-stream by binding to the same-name receptors – oxytocin receptor (OTR). The role of oxytocin in the development of TB is confirmed by the proven therapeutic effect of its receptor antagonists of the same name. Studies have found that increased expression of OTR in the myometrium and in the connecting uterine zone positively correlates with the amplitude of uterine contractions and can lead to the appearance of pathological and uncoordinated myometrial spasms, accompanied by severe dysmenorrhea and reduced fertility in women of reproductive age [9–12].
An Individualized Program to Treat a Child Who is “Gaming the System:” A Case Report
Published in Evidence-Based Practice in Child and Adolescent Mental Health, 2020
Anne S. Morrow, Micaela Baldivieso Gutierrez, Elizabeth M. Gnagy, Andrew R. Greiner, Erika K. Coles
Children with CU traits display maladaptive attachment styles more frequently, in that they have been described as more insecure and disorganized (Pasalich et al., 2012). More specifically, Pasalich et al. (2012) found that children with CU traits exhibit unpredictable behavior toward their parents in certain situations and demonstrate poorer quality attachments to their parents. Consistent with these behavioral findings, children with CU traits demonstrated impaired physiological development of attachment, as evidenced by higher methylation rates of the oxytocin receptor gene (a gene involved with a neurotransmitter that is linked to the development of attachments; Cecil et al., 2014). Functioning of the oxytocin receptor gene has been associated with both empathy and the ability to read the emotions of others (Insel, 2010), consistent with elements of the development of attachment formation (e.g., the construction of emotional representations).