Oxysterol-binding protein

Definition, risk factors, and epidemiology of osteoporosis

Published in Peter V. Giannoudis, Thomas A. Einhorn, Surgical and Medical Treatment of Osteoporosis, 2020

The integration of these technologies has also enabled the identification of new chromosomal (Chr) locations associated with osteoporosis such as previously unknown bone-related loci, for instance (72), 18p11.21 (C18orf19), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1), 10q21.1 (DKK1), Chr.1p13.2 for RAP1A, a member of the RAS oncogene family, Chr.2q11.2 for TBC1 domain family member 8 (TBC1D8), and Chr.18q11.2 for OSBPL1A, an oxysterol binding protein like 1A.

MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications

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Journal Information

Published in Expert Opinion on Therapeutic Targets, 2018

Romano Regazzi

Besides β cells, obesity and type 2 diabetes are also associated with changes in miRNA levels in insulin target tissues, contributing to insulin resistance and impaired glucose homeostasis. Different laboratories reported an upregulation of miR-143 in the liver of obese and diabetic mice [38,39]. Transgenic mice overexpressing this miRNA display defective insulin-stimulated AKT activation and impaired glucose homeostasis. These effects were attributed to the downregulation of oxysterol-binding-protein-related protein ORP8, a direct target of miR-143 [39]. Consistent with these observations, mice deficient for miR-143 were found to be protected from obesity-associated insulin resistance [39].

Oxysterol-binding protein

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Definition, risk factors, and epidemiology of osteoporosis

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