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Biochemical Parameters and Protein-Energy Malnutrition
Published in Anil Gupta, Biochemical Parameters and the Nutritional Status of Children, 2020
Nesfatin-1 is a peptide hormone that is secreted in the hypothalamus in humans. It plays a key role in the regulation of food intake and calorie homeostasis. A rise in the serum nesfatin-1 level leads to diminished intake of food and decline in hunger and decrease in storage of tissue fat.
The influence of bariatric surgery on serum levels of irisin and nesfatin-1
Published in Acta Chirurgica Belgica, 2019
Marta Majorczyk, Magdalena Staszkiewicz, Joanna Szklarczyk, Piotr Major, Magdalena Pisarska, Michał Wysocki, Tomasz Stefura, Artur Kacprzyk, Jakub Droś, Mateusz K. Hołda, Michał Pędziwiatr, Andrzej Budzyński, Jolanta Jaworek
The skeletal muscles and fat tissue play an important role in maintaining body homeostasis, also by releasing bioactive substances, such as myokines and adipokines. They regulate the maintenance of glucose homeostasis, craving, sensitivity to insulin and the transformation of energy [11]. Irisin and nesfatin-1 are two recently described peptides that might be involved in obesity-related insulin resistance [12,13]. Irisin is a myokine secreted from fibronectin type III domain containing 5 (FNDC5) skeletal muscles and has been recently described as an adipokine secreted by white adipose tissue, especially in the subcutaneous adipose tissue [14]. It has been proposed that irisin plays an important role in energy regulation, inducing conversion of white to brown adipose tissue, and in reducing obesity [15]. Nesfatin-1, a neuropeptide produced in the hypothalamus, participates in the regulation of hunger and fat storage [16]. Both molecules seem to be potential candidates for obesity therapy, because of their positive impact on the systemic energy metabolism [17,18].
Effects of Nesfatin-1 on Food Intake and Hyperglycemia
Published in Journal of the American College of Nutrition, 2020
Nesfatin-1 is a peptide produced in many tissues, especially in gastric mucosa. It acts as a metabolic regulator. Central and peripheral mechanisms contribute to the emergence of regulatory effects of this peptide. The combined anorexigenic and antihyperglycemic effects of nesfatin-1 may significantly affect food intake and glucose metabolism. Thus, it can play an important role in the metabolic control of the body. Nesfatin-1 can have positive effects on obesity, insulin resistance, and type 2 diabetes. Because of these beneficial effects, nesfatin-1 can be used in the treatment of obesity and Type 2 diabetes.
Effects of nesfatin-1 on atrial contractility and thoracic aorta reactivity in male rats
Published in Clinical and Experimental Hypertension, 2018
Ayşe Barutcigil, Arda Tasatargil
In conclusion, the present findings show that nesfatin-1 exhibits positive inotropic and chronotropic effects on spontaneously beating rat atria. Moreover, nesfatin-1 can induce arterial vasodilatation through endothelium-dependent mechanisms, and this effect may be related to the significant changes in NO-cGMP activity in rat thoracic aorta. However, according to the results presented, further studies need to be undertaken to validate these findings in animal models and to investigate the key underlying mechanisms guiding the action of nesfatin-1.