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Thyroid Tumors
Published in Dongyou Liu, Tumors and Cancers, 2017
Risk factors for thyroid carcinoma include past exposure to ionizing radiation in the head and neck region (particularly for PTC), family history of thyroid cancer or thyroid disease, familiar genetic disorders (e.g., multiple endocrine neoplasia type 2, particularly for MTC), and genetic mutations (e.g., BRAF-V600E, RAS, PTEN, CTNNB1, TP53, IDH1, NDUFA13 [GRIM19], RET, and PAX8/PPARG) [3].
Effects of psychoactive drugs on cellular bioenergetic pathways
Published in The World Journal of Biological Psychiatry, 2021
Chiara C. Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Mark F. Richardson, Nina Vasilijevic, Sheree D. Martin, Laura J. Gray, Sean L. McGee, Michael Berk, Ken Walder
After genome-wide correction for multiple testing using FDR, valproate significantly increased the expression of NDUFA13 (q = 0.037), NDUFA3 (q = 0.00012), NDUFB3 (q = 0.011), NDUFS8 (q = 0.049), NDUFV1 (q = 0.0090) and NDUFV3 (q = 0.00015) from Complex 1, UQCRFS1 (q = 0.030) and UQCRH (q = 3.6E-06) from Complex 3, COX4l1 (q = 0.038), COX6A1 (q = 0.036), COX7A2L (q = 1.5E-05) and COX7C (q = 0.0066) from Complex 4 and ATP5K (q = 0.041, Complex 5). Quetiapine increased the expression of COX6A2 (by 19 ± 1%, q = 5.59E-05, Complex 4), while lithium increased the expression of UQCRQ (by 20 ± 3%, q = 0.049, Complex 3) and COX6A2 (by 8 ± 2%, q = 0.00013, Complex 4).
Gene expression study of mitochondrial complex I in schizophrenia and paranoid personality disorder
Published in The World Journal of Biological Psychiatry, 2018
Arvin Haghighatfard, Sarah Andalib, Mozhdeh Amini Faskhodi, Soha Sadeghi, Amir Hossein Ghaderi, Shadi Moradkhani, Jalal Rostampour, Zeinab Tabrizi, Ali Mahmoodi, Talie Karimi, Zakieh Ghadimi
In present study, expression changes of 18 genes in SCZ patients and 11 genes in PPD patients were detected in mitochondrial complex I. Expression levels of NDUFS1, NDUFS4, NDUFV1, NDUFV2, NDUFB2, NDUFB5, NDUFB9, NDUFA5, NDUFA8, NDUFA13 and NDUFC1 were up-regulated and expression levels of NDUFAB1, NDUFB10, NDUFB11, NDUFA1, NDUFA2, NDUFS7 and NDUFS8 were down-regulated in chronic schizophrenic patients in comparison with non-psychiatric individuals. Also, expression levels of NDUFS1, NDUFV1, NDUFV2, NDUFB5, NDUFB9, NDUFA13, NDUFA8 and NDUFA5 were up-regulated and NDUFB11, NDUFS7 and NDUFS8 were down-regulated in the PPD group in comparison with the non-psychiatric group. Significant over-expression of NDUFS1 was found in paranoid schizophrenic (n = 297) and PPD patients (n = 340) in comparison with other subtypes of SCZ (total n = 337). Gene expression results are presented in Table 2 and Figures 2 and 3, which show a heat map of gene expression levels in group comparisons.