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Cardiovascular Risk Factors
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
A decrease in potassium and increase in sodium can have direct effects on available antioxidants and oxidation of lipids, especially within cell membranes. Both RAAS and SNS activity can increase free-radical generation, which further decreases available antioxidants and lipid peroxidation. Collectively, these steps create oxidative stress within the body.
Biochemical Aspects of Fatty Liver
Published in Robert G. Meeks, Steadman D. Harrison, Richard J. Bull, Hepatotoxicology, 2020
Regarding the possible reason for increased lipid peroxidation, Ugazio et al. (1967; 1971) put forward the hypothesis that it might be related to the increase in the peroxidizable substrate (i.e., unsaturated fatty acids) without a corresponding increase in the diet of liposoluble antioxidants, such as vitamin E. This would produce a derangement in the lipoperoxidative balance. According to Benedetti et al. (1977, 1980), in CCl4 poisoning lipid peroxidation would start from the phosphatidylcholine and phosphatidylserine portions of membrane phospholipids. So, the possibility arises that the substitution of phosphatidylcholine with these substances might represent another reason for increased susceptibility to lipid peroxidation in choline deficiency. The extent and quality of damage due to increased lipid peroxidation in this condition is, however, difficult to establish. Glucose-6-phosphatase, the marker enzyme of the SER, which is quickly inhibited after CCl4, and whose loss is surely dependent upon lipid peroxidation, is not modified in choline deficiency (Koga and Kirayama, 1968). This seems to show that in any case the sites affected firstly by lipid peroxidation are different in choline deficiency and in CCl4 treatment.
Buriti (Mauritia flexuosa L.) Oil Supplementation: Effects on Oxidative Stress and Hormonal Concentrations in Male Wistar Rats
Published in Megh R. Goyal, Hafiz Ansar Rasul Suleria, Ademola Olabode Ayeleso, T. Jesse Joel, Sujogya Kumar Panda, The Therapeutic Properties of Medicinal Plants, 2019
Boitumelo Rosemary Mosito, Nicole Lisa Brooks, Yapo Guillaume Aboua
Damage due to oxidative stress can decrease body and organ weights. The consumption of antioxidant-rich foods has shown to reduce oxidative stress damage hence protecting tissues from lipid peroxidation (LPO). Yuce [50] demonstrated that supplementation with cinnamon oil causes an increase in reproductive organ weights of male rats. Jargar [21] reported that diabetic ratson vitamin E supplementation gained both body and organ weights because their tissues were protected against LPO.
Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
Published in Pharmaceutical Biology, 2023
Jianjie Rong, Chuanyong Li, Qiang Zhang, Guangfeng Zheng, Weijian Fan, Zhichang Pan, Shuming Shi
EC ferroptosis is one of the initiating factors of AS (Ouyang et al. 2021). Therefore, ferroptosis-related indicators in the T2DM/AS model were tested. First, lipid peroxidation-related indicators were detected. Compared with that in the control group, in the T2DM/AS group, the GSH-Px enzyme activity was significantly inhibited (Figure 3(A)), whereas the oxidative stress damage indicators MDA (Figure 3(B)) and ROS were upregulated considerably (Figure 3(C), p < 0.01). By contrast, the GSH-Px activity was upregulated considerably after HSYA treatment, whereas MDA and ROS were significantly downregulated compared with that in the T2DM/AS group (p < 0.01). Furthermore, the intracellular iron ion contents were detected (Figure 3(D)), and the results showed that HSYA significantly inhibited iron ion accumulation in the aortic tissue (compared with that in the T2DM/AS group, p < 0.01). Western blotting (Figure 3(E–H)) showed that the ferroptosis inhibition-related proteins GPX4 and SLC7A11 were significantly upregulated because of HSYA, whereas the ferroptosis-promoting protein ACSL4 was significantly inhibited. Compared with the T2DM/AS group, the difference was statistically significant in the HSYA group (p < 0.01).
Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E
Published in Journal of Microencapsulation, 2023
Ran Tao, Qianyu Zhang, Jialing Duan, Ran Chen, Liyun Yao, Ruiteng Zhang, Gang Dong, Huali Chen
VC and VE worked together to play an antioxidant and synergistic effect (De la Fuente et al.2020, Jagdeo et al.2021, Puscion-Jakubik et al.2021). VC was effective in scavenging superoxide, hydroxyl, and peroxyl radicals. VE reacted at high speed with lipid peroxide radicals and interrupts the free radical chain, thus preventing further lipid peroxidation (Wefers and Sies 1988). Researchers had studied the interaction of vitamins C and E in the prevention of lipid peroxidation (Niki et al.1982). VC interacted with VE to obtain reactive VE, and they acted together in rats exposed to arsenic resulting in reduced levels of lipid peroxidation, protein carbonyl compounds, and hydrogen peroxide, and increased levels of reduced glutathione (Egel et al.2002, Frank et al.2003). This might be why VC and VE have potentiated antioxidant effects in the current study.
Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum) extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model
Published in Drug and Chemical Toxicology, 2023
Adedayo Oluwaseun Ademiluyi, Opeyemi Babatunde Ogunsuyi, Josephine Oluwaseun Akinduro, Olayemi Philemon Aro, Ganiyu Oboh
This study revealed that there was a significant increase in ROS (as quantified as H2O2 equivalent) content in Mn treated flies. However, the dietary inclusions of SL and WB leaves alkaloid extracts significantly prevented the elevation in ROS contents. One of the justifications for this observation could be as a result of the ability of dietary inclusions of SL and WB leaves to significantly reduce MAO activities in Mn treated flies as earlier discussed. Secondly, the antioxidant properties of SL and WB leaves could have also contributed to their abilities to reverse elevation in ROS content in Mn assaulted flies. Previous studies (Oboh et al. 2014, Ademiluyi et al. 2015) have shown that green leafy vegetables that are rich in antioxidant phytochemicals are capable of inhibiting lipid peroxidation chain reactions. Impairments in endogenous antioxidant defense systems such as catalase, glutathione (GSH), superoxide dismutase (SOD), and glutathione-S-transferase (GST) are possible consequences of oxidative stress. To further support the antioxidant properties of SL and WB extracts, it was also observed that there was increase in activities of catalase and GST in flies fed diets containing the extracts alone.