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Melasma
Published in Dimitris Rigopoulos, Alexander C. Katoulis, Hyperpigmentation, 2017
Clio Dessinioti, Andreas Katsambas
Lignin peroxidase is an enzyme derived from the tree fungus Phanerochaete chrysosporium that may break down melanin. Lignin peroxidase in a cosmetic lotion formulation was investigated in a randomized controlled, split-face trial in 60 female patients with mild to moderate facial dyspigmentation. This preparation was applied twice daily for 12 weeks and resulted in similar skin lightening as 4% HQ with no adverse events or tolerability issues noted.47
COVID-19: captures iron and generates reactive oxygen species to damage the human immune system
Published in Autoimmunity, 2021
By using Uniprot to find the Ref protein name of the fungi peroxidase sequence, we got three groups of protein names: R7T0H4->XP_007365204.1; R7SP50->XP_007370520.1; R7SH99-> XP_007272084.1. The E protein corresponding to R7SH99 was “YCCNIVNVSLVKPSFYVYSRVKN”, which contained the haem linked site "YCC". In the NCBI webpage, there was no “Related Structures (Summary)” content for these three proteins. After clicking “Conserved Domains (Concise)” in the NCBI webpage of these three proteins, the introduction of “cd00692: Ligninase; Ligninase and other manganese-dependent fungal peroxidase” was displayed, suggesting that the fungal PEROXIDASE_4 type domain was lignin peroxidase. Taken together, the above analysis results showed that the E protein had the catalytic role of the peroxidase enzyme after binding to haem. E protein catalysed the formation of hydrogen peroxide, even ·OH.
Melasma treatment: a systematic review
Published in Journal of Dermatological Treatment, 2022
Nicoleta Neagu, Claudio Conforti, Marina Agozzino, Giovanni Francesco Marangi, Silviu Horia Morariu, Giovanni Pellacani, Paolo Persichetti, Domenico Piccolo, Francesco Segreto, Iris Zalaudek, Caterina Dianzani
Hydroquinone and triple combination creams containing HQ, like Kligman formula and Tri‐Luma remain one of the best treatment options for melasma. Mild adverse events have been associated with HQ application. TXA 5%, lignin peroxidase, petroselium crispum solution, silymarin cream, and 4% diacetyl boldine serum seem to be an efficacious alternative to HQ products, with comparable results. Newer products, containing 1% flutamide or 0.2% thiamidol had encouraging results, with no adverse events reported and apparently superior to HQ.