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Toxicity of Antineoplastic Chemotherapy in Children
Published in Sam Kacew, Drug Toxicity and Metabolism in Pediatrics, 1990
Theodore Zwerdling, Steven K. Bergstrom, Stephen D. Smith
In aqueous solutions, BCNU spontaneously decomposes, producing chloroethyl carbonium ions which alkylate DNA. Also an isocyanate group is formed which reacts with amines in a carbamoylation reaction. BCNU is administered orally or intravenously in a dose of 60 to 300 mg/M2 and has an initial half-life of 6 min. BCNU is metabolized by the liver with metabolites excreted by the kidneys.
Synthesis and anti-hepatocellular carcinoma activity of aminopyridinol–sorafenib hybrids
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Bhuwan Prasad Awasthi, Prakash Chaudhary, Diwakar Guragain, Jun-Goo Jee, Jung-Ae Kim, Byeong-Seon Jeong
A key feature of the synthesis of compound 4, a hybrid structure of sorafenib and aminopyridinol, is to combine the moieties at both ends of sorafenib, i.e. 4-chloro-N-methylpicolinamide and 4-chloro-3-(trifluoromethyl)phenyl isocyanate, with centrally located 6-amino-2,4,5-trimethylpyridin-3-ol (2) (Scheme 1). The formation of the ethereal bond of 3 by nucleophilic aromatic substitution reaction between the oxygen atom of the hydroxyl group in 2 and the carbon atom with chloride in 4-chloro-N-methylpicolinamide was carried out under microwave irradiation with potassium tert-butoxide base in a sealed tube. Then, the other substructure of sorafenib was linked to the aminopyridinol centre by nucleophilic addition reaction of the nitrogen atom in the amino group of 3 to the carbon atom in the isocyanate group in 4-chloro-3-(trifluoromethyl)phenyl isocyanate to form ureido compound 4. The key intermediate 2 was readily prepared by the well-established method which was developed by us starting from pyridoxine hydrochloride20.
The effect of initiator encapsulation on methyl methacrylate polymerization by isothermal differential scanning calorimetry
Published in Journal of Microencapsulation, 2020
Seok Min Lee, Mi Rae Kim, Hee Jung Park, Kang Ho Cheon, Kee Yoon Lee
Encapsulation of initiators was carried out by following the same method as was described in the previous study (Kwon et al. 2019). Aqueous TETA solution was added to a dispersed oil droplet solution which was formed when an organic solution of initiator (CHP or TBPEH) and polymeric 4,4’-MDI was stirred in aqueous PVA solution. Then, a microcapsule containing an initiator as a core was prepared by the condensation polymerisation of an isocyanate group in an oil phase and an amine in the aqueous phase. During the reaction, the emulsion was continuously stirred at a constant agitation speed.