China
Africa
Explore chapters and articles related to this topic
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
There are no reports in the literature concerning effects of Cecropia species on pregnancy outcome. Pregnant female rats that received 1.0 g/kg of extract per day throughout pregnancy gave birth to normal pups. The weight and the physical development of both genders of pups were not affected, but the uprightness latency and the negative geotaxis reflexes were enhanced and the rearing frequency decreased. The toxicity to pregnant females and pups was deemed low.17
Clonorchis
Published in Dongyou Liu, Handbook of Foodborne Diseases, 2018
Cercariae swim actively by means of the tail in search for the second intermediate host, usually freshwater fish, helped by a positive photo-, thermo-, and geotaxis.6 Their life span is 22–26 hours at water temperature 20°C–23°C. Cercariae penetrate into the fish body (using the secret of their penetration glands) and encysted under the skin or into the muscle. Maturation of the metacercariae requires 30–45 days depending on water temperature; simultaneously, their number can reach several thousands in one fish. Metacercariae have high potential stability and viability.20
Role of Mitochondria in Cell Aging
Published in Alvaro Macieira-Coelho, Molecular Basis of Aging, 2017
The age-related decline in physiological performance and energy production that is probably linked to mitochondrial dysfunction is not only seen in human subjects, but is an universal characteristic of the metazoan phenotype as shown by data from our laboratory on the age-related loss of control of body weight,25 neuromuscular coordination,26 and immunological competence27 in mice, as well as of negative geotaxis28 and mating competence29 in Drosophila fruit flies.
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems
Published in Drug and Chemical Toxicology, 2023
Opeyemi Babatunde Ogunsuyi, Olayemi Philemon Aro, Ganiyu Oboh, Olawande Chinedu Olagoke
Using the negative geotaxis experiment described by Adedara et al., the locomotor behavior of the treated and control flies was evaluated (2016). The capacity of the flies to recognize negative geotaxis was used to the benefit of the assay, which was carried out in a cylindrical tube. The findings are shown as a percentage of flies that managed to fly away in less than 30 s from three separate studies across a minimum distance of 6 cm. The aversive phototaxis suppression experiment (Berger et al. 2008) was used to analyze the flies’ memory index (Ogunsuyi et al. 2020). The test was conducted in a T-maze and connected the flies’ positive phototaxis with their dislike of the bitter taste of quinine. At 0 and 6 h, the memory index was recorded. The studies were performed in triplicate (n = 5), and two-way analysis of variance of mean was performed. Tukey’s post hoc test was used to determine the threshold of significance, which was set at p 0.05.
Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy
Published in Upsala Journal of Medical Sciences, 2020
Mehrnaz Haghi, Raheleh Masoudi, Seyed Morteza Najibi
Locomotive defects can be examined in transgenic flies as one of the AD symptoms. Here, we tested negative geotaxis ability as a behavioural assay to show that the expression of our target genes can affect the natural tendency of flies to move against gravity (29,30). To assess the climbing ability, 5- and 25-day-old transgenic flies were examined. It was found that the ability of climbing in both transgenic flies was remarkably decreased compared to their controls. The raw data and Bayesian estimation of difference between controls and transgenic flies are depicted in Figure 1 (for more details see Table 1; and also Supplementary Table S2).
Methanol fraction of Ficus mucoso (welw) prevents iron-induced oxidative damage and alters mitochondrial dysfunction in Drosophila melanogaster
Published in Drug and Chemical Toxicology, 2022
Olubukola T. Oyebode, Amos O. Abolaji, Hammed O. Faleke, Olufunso O. Olorunsogo
Climbing ability or negative geotaxis is one of the behavioral features to examine neural balance and coordination in D. melanogaster (Rhodenizer et al.2008). The MFFM significantly improved the rate at which the flies survived when co-administered with FeSO4 for 14 days. The observation that FeSO4 retarded the ability of the flies to climb consequently compromising the fly’s negative geotaxis while treatment with MFFM showed improved locomotor activity suggests repair of oxidative damage in flies by MFFM.