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Microneedling
Published in Rubina Alves, Ramon Grimalt, Techniques in the Evaluation and Management of Hair Diseases, 2021
Rachita S. Dhurat, Sanober Burzin Daruwalla
In addition to above mentioned mechanisms, the different mechanisms of microneedling have been proposed. In 2010, Liebl proposed that microneedling could be used in treating chronic wounds. He theorized that the mechanisms for the main action of microneedling may include transepithelial potentials (TEPs) and the skin battery [23]. To elicit a desired response from microneedling about two hundred needle pricks are created per cm2 of skin. The cells around the needle channels likely sense the reoccurring penetrations as new (repeated) induced wound stimuli and therefore are in a permanent active state that leads to a polarized electro-magnetic field (EMF) in the inter-cellular electrolyte. The EMF stimulates DNA-expression of the surrounding cells. This epigenetic DNA-information by electrotaxis leads to an enhanced motility of epithelial and endothelial cells in the wounded area and subsequently to gene expression of growth factors that facilitate healing [24].
Microfluidic Systems to Study the Biology of Human Diseases and Identify Potential Therapeutic Targets in Caenorhabditis elegans
Published in Iniewski Krzysztof, Integrated Microsystems, 2017
Pouya Rezai, Sangeena Salam, P. Ravi Selvaganapathy, Bhagwati P. Gupta
In recent years, several new applications of microfluidics in C. elegans have emerged that include phenotypic sorting, cell ablations, drug exposure, and behavioral studies [105–107,109,112]. Because of their focus on imaging cells and/or certain regions of the worm, they rely on pneumatics to immobilize animals. These devices have been successful in automating some steps and providing an increased throughput that is not possible with traditional manual approaches. While advantageous in many applications, they are not suitable to study movement behaviors of worms in the absence of an external force. In this respect, an electric field-based microfluidic approach promises to be useful as it offers a convenient method to control movement [129,130]. Furthermore, since the movement relies on coordinated activities of neurons and muscles, it provides strong support to the idea that a microfluidic device incorporating electric field control mechanism may accelerate the study of movement-related disorders (e.g., HD, PD, and DMD) in worm models. This stimulus-based approach will benefit from a number of factors that favor the use of the electric field in a microfluidic environment. These include easy and inexpensive setup, instantaneous on/off control, no gradient or decay over time, compatibility with liquid culture media, scalability, and the ability to induce movement in a desired direction without sensory adaptation. The ongoing work in our laboratories has shown that the electrotaxis behavior is a highly sensitive measure of the function of neurons and muscles since any defect can be quickly revealed in a microfluidic assay in the form of reduced speed, altered body bends, and sporadic pauses. Therefore, we believe that the microfluidic electrotaxis approach could serve as a powerful tool to facilitate high-throughput study of C. elegans disease models, identify molecular changes and genetic pathways, and screen for chemicals/drugs as candidates for potential treatment options.
Hypothesis: The electrical properties of coronavirus
Published in Electromagnetic Biology and Medicine, 2020
For the last few decades, scientists studied the effects of mechanisms involve suppression by inhibition of chemotaxis, but it may affect the electrotaxis as well. Hydroxychloroquine, a drug used to treat Covid-19. One of the inhibitory effects of these drugs on chemotaxis (Hurst et al. 1987; Ward 1966). To investigate the electrotaxis that can be considered a dominating signal during cell migration (besides the underlying by an electric field or current) (Mousavi et al. 2013). Also, may help explain the presence of electromotive force established via reacts hydroxychloroquine when used to the treatment.
Eye-on-a-chip (EOC) models and their role in the future of ophthalmic drug discovery
Published in Expert Review of Ophthalmology, 2020
Zhiting Peng, Liangyu Zhou, Jasper Ka Wai Wong, Yau Kei Chan
Cornea homeostasis has also been investigated on EOC platforms. Electrotaxis has been suggested to be a novel treatment option of healing corneal wounds both in-vitro [23,24], and on human subjects [25]. This concept was re-confirmed on a microfluidic platform that allows high-throughput electrotaxis-related studies on cells [26]. The results showed that directional cell migration is dependent on the electrical field strength, and demonstrated the potential of this platform on preliminary drug screening for corneal wound healing applications.