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The Application of Rest in Chore and Other Functional Nervous Diseases; and in Organic Nervous Diseases
Published in Francis X. Dercum, Rest, Suggestion, 2019
Rest methods are also occasionally of value in functional spasms and functional tremor, though permanent results are never achieved. Every now and then, in a case of spasmodic torticollis, in which the movements are excessive in their severity, benefit can be obtained by placing the patient in bed upon full rest methods, and especially will this be the case if some motor depressor, such as conium or gelsemium, be administered coincidently. Gelsemium particularly is of value. In large doses it is, of course, a poison and its use should always be attended with care. It may be given in the form of the fluid extract, beginning with five drops and with intervals of several hours. Four hours is a convenient interval, as the effect of a single dose lasts from three to four hours. Gradually the dose should be increased to ten, fifteen, or even twenty drops. Twenty drops, indeed, should be considered the maximum dose, and should not under ordinary circumstances be exceeded. During its administration, the patient should be watched, and if ocular symptoms, such as double vision, make their appearance, the drug should, for a time, be discontinued. During the use of this agent the spasm diminishes to a very great extent, and in some cases almost ceases, though I believe it has never been known to do so entirely. However, so pronounced is the amelioration that it affords, especially if its administration be attended by the employment of full rest measures, that the patient is very materially benefited.
Nutraceutical’s Role in Proliferation and Prevention of Gynecological Cancers
Published in Sheeba Varghese Gupta, Yashwant V. Pathak, Advances in Nutraceutical Applications in Cancer, 2019
Aaishwarya B. Deshmukh, Jayvadan K. Patel, Bharat Mishra
In U14 cervical carcinoma cells in mice exposed to betulinic acid as a food supplement have shown antitumor activity. Ethanolic extract of Conium maculatum (hemlock) inhibits the proliferation of cells within 48 hours by arresting the cell cycle at sub-G stage. Methanol extracts and ethyl acetate of M. pajang kernel and chloroform and crude petroleum ether extracts of the stem bark, respectively, have produced strong cytotoxic activity against the HeLa cervical carcinoma cell line [72]. Oridonin has the potential to inhibit the P13K-Akt pathway in HeLa cell line. Emodin and curcumin have the ability to downregulate P-Smad3, Smad4, and TGF-β receptor II, which, in turn, suppress the migration and invasion induced by TGF of cell lines in HeLa and SiHa cervical cancers [71]. Curcumin and emodin suppresses the CyclinD1, p15, p16, p21, p27, CDK6, and Pin1 expression by upregulating the Bax:Bcl-2 ratio, thereby suppressing the Wnt/β-catenin in HeLa cells. SiHa cells were chosen for TGF-β resistance, as they lack remarkable growth inhibition when treated with TGF-β [71].
Plants*
Published in Bev-Lorraine True, Robert H. Dreisbach, Dreisbach’s HANDBOOK of POISONING, 2001
Bev-Lorraine True, Robert H. Dreisbach
The pathologic findings in Cicuta poisoning are similar to those from picrotoxin (see p. 516). The pathologic findings in Conium poisoning are inflammation of the gastrointestinal tract with congestion of the abdominal organs.
Plant identification applications do not reliably identify toxic and edible plants in the American Midwest
Published in Clinical Toxicology, 2023
Kevan Long, Andrew Townesmith, Alex Overmiller, Wendy Applequist, Anthony Scalzo, Paula Buchanan, Cindy C. Bitter
Information on the toxicity of plants was inconsistently offered and was not analyzed. PlantSnap identified several toxic plants as edible, including Menispermum canadense identified as Vitis spp., Conium maculatum misidentified as Petroselinum spp. (parsley) and Molopospermum peloponnesiacum (cuscullo or couscouille, a European edible and folk medicinal plant). Ornithogalum umbellatum was misidentified as Allium spp. by multiple apps, and Cicuta maculata was misidentified as Daucus spp. by PlantSnap and LeafSnap.
Mistaken identity: acute respiratory arrest from accidental ingestion of poison hemlock
Published in Clinical Toxicology, 2022
Kai Li, Hillary Bassett, Briana Fitch, Kara Lynch
Toxicity from poison hemlock was suspected early on in the ED course based on the history of proceeding ingestion of a foraged plant and the characteristic appearance of the sample plant provided by the family. Poisoning was confirmed by the identification and quantification of serum coniine concentrations. Unintentional Conium poisonings have previously resulted from the confusion of poison hemlock with fennel (Foeniculum vulgare), “wild carrots” (Daucus carota), and dwarf everlast (Helichrysum arenarium) [3–6].