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Emotional Wellness and Stress Resilience
Published in Michelle Tollefson, Nancy Eriksen, Neha Pathak, Improving Women's Health Across the Lifespan, 2021
Gia Merlo, Ariyaneh Nikbin, Hanjun Ryu
Nevertheless, we are not powerless as individuals. As medical professionals, we also have a mandate to take care of ourselves, just as we aim to take care of our patients. There are steps we can take to abate and adapt to the stresses of the medical profession and protect ourselves from burnout. Adaptation is a normal response that follows a newfound stimulus, and all physicians adapt to the stressors of the healthcare environment in one way or another. Crucially, though, adaptation can be either positive or negative, and when we engage in maladaptive responses to occupational stress, we may be putting ourselves at risk of burnout. By developing an understanding that stress is normal and not any fault of our own, and by training for adaptive and healthy coping responses, we may be able to develop resilience against burnout at the individual level. Additionally, by learning how to adaptively cope with the stressors inherent in our jobs as clinicians, we will be better able to help our patients mitigate their own stress, deliver better quality of care, and improve our patients’ outcomes.
Genetics and genomics of exposure to high altitude
Published in Andrew M. Luks, Philip N. Ainslie, Justin S. Lawley, Robert C. Roach, Tatum S. Simonson, Ward, Milledge and West's High Altitude Medicine and Physiology, 2021
Andrew M. Luks, Philip N. Ainslie, Justin S. Lawley, Robert C. Roach, Tatum S. Simonson
Despite tremendous progress on the genomics front, the precise functional variants that provide benefits in Tibetans remain largely unknown. One exception is the EGLN1 gene, whereby variants in the first exon found at high frequency in Tibetans (Asp4Glu; Cys127Ser) exhibit a gain of PHD2 function (a lower Km for oxygen), which leads to increased HIF degradation under hypoxic conditions and a potential disruption in erythroid progenitor proliferation (Lorenzo et al. 2014). Other reports suggest these variants underlie loss of PHD2 function via defective binding of cochaperone p23 that would lead to increased HIF activity (Song et al. 2014). A study examining gene expression in a population from India indicates genetic variants within the first intron of EGLN1 lead to increased expression and high altitude pulmonary edema (HAPE) (Aggarwal et al. 2010). More recent analyses of whole genome sequences (Hu et al. 2017) indicate that nonprotein coding variants, including those in heterochromatic or DNA methylated portions of the genome, are crucial for adaptation. In such cases, the effects of increased or decreased gene expression could vary across tissues and/or stages of development (in contrast to protein-coding variants that result in uniform alterations across all cells). An understanding of these changes could provide much needed insight into molecular mechanisms of adaptation.
Equity in healthcare services
Published in Songül Çınaroğlu, Equity and Healthcare Reform in Developing Economies, 2020
Therefore, effective market regulations are essential for the sustainability of this market and enabling accessibility of new drugs for the vulnerable population. Obviously, considering equity is a significant concern for health policymakers who are regulating the pharmaceutical market (Feyzrakhmanova and Gurdgiev, 2016). Rational usage of resources and effective resource planning is an integral part of this process. Thus, specific HTA analysis techniques such as cost-effectiveness analysis should be an integral part of the assessment of the new technologies in the pharmaceutical market (Leung et al., 2013). On the other hand, however, health professionals are faced with struggles during the adaptation process of new health technologies and innovations (Jha and Topol, 2016). Therefore, it is highly advisable that health policymakers from LMICs prepare specific education programs and continually monitor the level of usage of advanced health technologies to enable easy adaptation of innovations in healthcare.
The relationship between stress, anxiety, and depression levels and pseudobulbar affect in patients with multiple sclerosis
Published in Contemporary Nurse, 2022
Duygu Özer, Elvan Emine Ata, Gül Dikeç, Serkan Demir
This study shows that MS patients experience severe mental health problems and highlights the need for psychiatric treatment and care in addition to neurological treatment in MS. The results of the study indicate that consultation-liaison psychiatry services, which are insufficient in Turkey, should be increased and that MS patients should benefit from comprehensive psychiatric services. Nurses should holistically assess and care for MS patients and plan preventive mental health interventions in the early period to encourage disease adaptation and prevent mental health problems. It may also be advisable to plan psychoeducation that encompasses the disease, its natural course, potential complications, emergency case plans and effective coping methods. In addition, adjustments to patient’s living conditions, home environment, and daily life activities can be made to facilitate adaptation to their current circumstances.
Declaring an End to the Pandemic: What Are the Issues?
Published in Issues in Mental Health Nursing, 2022
Adaptation is the ability to adjust to new information and experiences (Corpuz, 2021). Putting new knowledge into practice essentially means adapting to our constantly changing environment. Through adaptation, we are able to adopt new behaviors that allow us to cope with change and in the case of a lethal virus to survive in an altered environment. Adaptation is a major concept in several disciplines—anthropology, sociology, psychology, physiology, and nursing. In each of these spheres, a change in environment promotes or even requires adaptive responses in order to survive. The deadly corona virus required changes in each of these domains and our ability to master the virus depended on our ability and willingness to adapt—make changes. In this scenario, going back to what was normal behavior is not an option (Corpuz, 2021).
Childhood Loss Experiences, Religiousness/Spirituality, and Hope as Predictors of Adult Life Satisfaction
Published in Issues in Mental Health Nursing, 2021
Linda C. Mefford, Kenneth D. Phillips, Misook L. Chung
Adaptation is the response to an environmental threat that disrupts health, with individuals having a wide repertoire of potential adaptive patterns to conserve health and wholeness (Levine, 1966, 1969, 1996). Levine proposed four conservation principles from which to base the development of both therapeutic and supportive interventions: conservation of energy, structural integrity, personal integrity, and social integrity (Levine, 1967, 1989, 1996). Interventions to promote healing from childhood loss should support adaptation by using the four conservation principles to guide holistic healing (Mefford, in press). This study focused on childhood loss (as the environmental threat) and adaptive patterns of religiousness/spirituality and hope (both reflecting adaptive efforts to conserve personal integrity and social integrity). The theoretical variable of adaptation was reflected in this study by measures of hope and religiousness/spirituality.