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Affinity Modification — Organic Chemistry
Published in Dmitri G. Knorre, Valentin V. Vlassov, Affinity Modification of Biopolymers, 1989
Dmitri G. Knorre, Valentin V. Vlassov
Thousands of papers have been published on the problem of interaction of metal ions with nucleic acids and proteins. Some cations play central roles in enzymatic catalysis being enzyme cofactors such as zinc in carboxypeptidase or part of enzyme prosthetic groups such as iron in hemoglobin. This branch of bioorganic chemistry is considered as a separate field of science, bioinorganic chemistry. However, the use of metal ions as reactive groups of affinity reagents is only beginning. Two essential properties of metal ions, namely the ability to coordinate functional groups of biopolymers as ligands and to act as oxidative-reducing catalysts, suggest some prospective applications of the metal ions in affinity modification. In this section we shall describe the recent experiments where complexes of some metals were used as affinity reagents, and attempts have been made to design catalytic affinity reagents.
Stimulating and Depressing Radiotracer Metabolism
Published in Lelio G. Colombetti, Principles of Radiopharmacology, 1979
Garimella V. S. Rayudu, Ernest W. Fordham
With the availability of high specific activity radionuclidic compounds, the authors think that the study of stimulation and depression of radiotracer metabolism will add a new dimension in the understanding of physiopathology of various human organs. However, the subject is still in its infancy, except for organs such as adrenals, pancreas, and thyroid. In order to conveniently deal with the vast and diverse nature of this topic, the information to be covered has been divided into three parts: (1) diagnostic medicine, (2) bioinorganic chemistry, and (3) bioorganic chemistry.
Ball milling: a simple and efficient method for quantitative solvent-free synthesis of new potential bioactive Ni(II) and Co(II) complexes
Published in Egyptian Journal of Basic and Applied Sciences, 2021
Rania Zaky, Aisha Y. Al-Dawood, Zehba A. Al-Ahmed
Metals complexes are fundamental cellular components chosen to function in numerous essential biochemical processes for living organisms. Generally, metals have unique characteristics that involve reactivity toward organic substrates, variable coordination modes, and redox activity. For these reasons, the design of special coordination complexes, whichever as drug or pro-drug, is considered the main target to get a powerful tool in cancer diagnosis [5–8]. Based on the interface between molecular bioinorganic chemistry and biological system, the design of coordination complexes for cancer treatment in the current research is extensive in scope, targets multiple cellular and biological properties of many types of tumor. Recently, the improvement of anticancer drugs stimulated from cytotoxicity toward the design of selective agents, which act on definite cellular targets [9–11].
The current progress in the use of boron as a platform for novel antiviral drug design
Published in Expert Opinion on Drug Discovery, 2022
Shuo Wang, Yujie Ren, Zhao Wang, Xiangyi Jiang, Shujing Xu, Xujie Zhang, Shujie Zhao, Waleed A Zalloum, Xinyong Liu, Peng Zhan
Drug design utilizing boron-containing compounds remains a relatively new field. As a semimetal, boron has unique chemical characteristics that exhibit outstanding effectiveness in the design of agents against drug-resistant viruses. Combined with medicinal chemistry, bioinorganic chemistry, and structural biology, it is expected that more peculiar features of boron-containing compounds will be explored for novel drug design.
DNA binding, BSA interaction and in-vitro antimicrobial studies of Cu(II), Co(III), Ni(II) and VO(IV) complexes with a new Schiff base
Published in Egyptian Journal of Basic and Applied Sciences, 2020
Disha Sharma, Hosakere D. Revanasiddappa, Basavegowda Jayalakshmi
However, few studies on the interaction between Schiff base complexes and DNA (or BSA) were reported. An experiment on the DNA binding properties of metal complexes is a leading subject of bioinorganic chemistry since it provides the development of metal-based drugs [6,7].