BTB-POZ domain

BTB-POZ domain

A BTB/POZ domain is a protein domain found in various proteins, including FAZF and BCL6, that is implicated in various biological processes such as oncogenesis, limb morphogenesis, hematopoiesis, and cell proliferation. The domain is located in the N terminus of the protein and is involved in homo-dimerization of BCL6 molecules, which recruits additional corepressor molecules and forms a multi-molecular complex with SMRT and NCOR or BCOR.From: Chromosomal Instability and Aging [2019], BCL6 as a therapeutic target for lymphoma [2018]

Micronutrients in the Prevention and Improvement of the Standard Therapy for Alzheimer’s Disease

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Published in Kedar N. Prasad, Micronutrients in Health and Disease, 2019

Kedar N. Prasad

Treatment of hippocampal cell culture with Aβ peptides downregulated the expressions of miR-9 and miR-181c and increased the levels of their target proteins TGF-beta1, TREM2 (triggering receptor expressed on myeloid cells 2), SIRT1 (silent information regulator 1), and BTBD3 (BTB/POZ domain-containing protein 3).86

BCL6 as a therapeutic target for lymphoma

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Published in Expert Opinion on Therapeutic Targets, 2018

Rebecca J Leeman-Neill, Govind Bhagat

BCL6 belongs to the Broad-Complex, Tramtrack and Bric a brac/Pox virus and Zinc Finger (BTB/POZ) family of transcription factors that functions as a transcriptional repressor. The C terminus contains C2H2 zinc finger domains that interact with DNA, allowing BCL6 to bind and repress its target genes. The N terminus contains a BTB/POZ domain that, upon homo-dimerization of BCL6 molecules, recruits additional corepressor molecules and forms a multi-molecular complex with SMRT and NCOR or BCOR [6–8]. The middle part of the protein contains an additional repressor domain, RD2 [6,9] (Figure 1). The BCL6 interactome is vast and BCL6 can interact with and influence the function of myriad proteins either directly or indirectly. Co-immunoprecipitation and liquid chromatography–mass spectrometry (LC–MS) studies have identified numerous BCL6 interacting proteins, which comprise transcription factors (including transcriptional corepressors), signaling mediators, catalytic enzymes, and others [10].

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Micronutrients in the Prevention and Improvement of the Standard Therapy for Alzheimer’s Disease

BCL6 as a therapeutic target for lymphoma