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Rapid Formation of Plasma Protein Corona Critically Affects Nanoparticle Pathophysiology
Published in Lajos P. Balogh, Nano-Enabled Medical Applications, 2020
Stefan Tenzer, Dominic Docter, Jörg Kuharev, Anna Musyanovych, Verena Fetz, Rouven Hecht, Florian Schlenk, Dagmar Fischer, Klytaimnistra Kiouptsi, Christoph Reinhardt, Katharina Landfester, Hansjörg Schild, Michael Maskos, Shirley K. Knauer, Roland H. Stauber
Immunoblotting. Immunoblotting was carried out as described previously [15]. Antibodies were α-actin (Sigma Aldrich), α-apoA4 (Cell Signaling), α-apoE, α-clusterin, α-gelsolin, α-prothrombin, goat-α-rabbit immunoglobulin G (IgG) Ab and rabbit-α-mouse IgG Ab conjugated with horseradish peroxidase (Santa Cruz), α-kininogen-1 and α-serum amyloid A (Abcam).
Gene–Diet Interactions
Published in Nathalie Bergeron, Patty W. Siri-Tarino, George A. Bray, Ronald M. Krauss, Nutrition and Cardiometabolic Health, 2017
Silvia Berciano, Jose M. Ordovas, Nathalie Bergeron, Patty W. Siri-Tarino, George A. Bray, Ronald M. Krauss
Some pioneering studies in the field of gene–diet interactions and cardiometabolic health relate to candidate genes in the path of lipoprotein metabolism, specifically associated with the APOE and the APOA1/APOC3/APOA4/APOA5 gene cluster. However, whereas there are clear and consistent associations between some of these loci and plasma lipid concentrations, the results from gene–diet interactions suffer from the similar lack of replication found for other metabolic pathways.
Proteomic global proteins analysis in blast lung injury reveals the altered characteristics of crucial proteins in response to oxidative stress, oxidation-reduction process and lipid metabolic process
Published in Experimental Lung Research, 2022
Peifang Cong, Changci Tong, Shun Mao, Xiuyun Shi, Ying Liu, Lin Shi, Hongxu Jin, Yunen Liu, Mingxiao Hou
Recently, lipid metabolism disorders are associated with many diseases, such as chronic kidney disease, autoimmune diseases, lung cancer, acute lung injury and so on.51–53 ACOX2 is a lipolysis related gene that catalyzes key step of peroxisome β-oxidizes and is involved in bile acid production. Studies have shown that its transcript levels are negatively correlated with triglyceride levels and may be associated with oxidative stress and with lipid metabolism diseases.54 HSD11b1 is a kind of 11 b-hydroxysteroid dehydrogenases, which are widely expressed in metabolically active tissues and are involved in reverse oxidation. Studies have also shown that overexpression of HSD11b1 is associated with visceral obesity, insulin resistance, hyperlipidemia and hypertension.55,56 In-vivo studies have shown that inhibition of HSD11b1 has a beneficial effect on lipid mass spectrometry.57 Several preclinical studies have demonstrated that deletion or inhibition of HSD11b1 can reduce atherosclerotic plaque in addition to reducing cardiovascular risk factors.58 APOA4 is a 46 KD glycoprotein which belongs to the apolipoprotein family. It is involved in preventing atherosclerosis, reverse cholesterol transport, anti-inflammatory and intestinal lipid absorption.59,60 In recent years, it was reported that APOA4 could mediate metabolism of chyle particle, regulating triglyceride secretion and improvement of glucose homeostasis.61 In our study, increasing HSD11b1 and decreasing ACOX2 and APOA4 demonstrated that lipid metabolic process was interrupted after blast exposure, which would increase cholesterol and triglyceride level (Figure 6). This may increase the risk of lipid metabolism related diseases in people experienced blast exposure.