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Purine and urate metabolism
Published in Martin Andrew Crook, Clinical Biochemistry & Metabolic Medicine, 2013
The amino group of glutamine is incorporated into the ribose phosphate molecule and pyrophosphate is released. Amidophosphoribosyl transferase catalyses this rate-limiting or controlling step. The enzyme is subject to feedback inhibition by increasing concentrations of purine nucleotides; thus the rate of synthesis is slowed when its products increase. The control of this rate-limiting step may be impaired in primary gout.
Transport and Metabolism of Glutamine and Glutamate in the Small Intestine
Published in Elling Kvamme, Glutamine and Glutamate in Mammals, 1988
Peter J. Hanson, Dennis S. Parsons
Glutamine probably does not play a part in the de novo synthesis of purine nucleotides in the rat small intestine under normal circumstances and the activity of the enzyme glutamine-amidophosphoribosyltransferase (EC 2.4.2.14) in mucosal scrapings is significantly lower than that in the liver and colon. If the diet becomes deficient in purines then small intestinal mucosal cells may be able to perform de novo synthesis of purines from glutamine.60
Porphyromonas gingivalis diffusible signaling molecules enhance Fusobacterium nucleatum biofilm formation via gene expression modulation
Published in Journal of Oral Microbiology, 2023
Yukiko Yamaguchi-Kuroda, Yuichiro Kikuchi, Eitoyo Kokubu, Kazuyuki Ishihara
Eighty-seven genes were downregulated (Table 2), including those encoding protein involved in de novo synthesis of purine (phosphoribosyl amine-glucine ligase, purH, class I SAM-dependent methyltransferase, phosphoribosyl glycinamide formyl transferase, purM, amidophosphoribosyltransferase, phosphoribosylaminoimidazole-succinocarboxamide synthase, purE, and phosphoribosylformylglycinamidine synthetase), proteins involved in de novo pyrimidine synthesis (bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR, aspartate carbamoyltransferase, dihydroorotase, glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit, carbamoyl-phosphate synthase large subunit, dihydroorotate dehydrogenase electron transfer subunit, dihydroorotate dehydrogenase, orotidine 5’-phosphate decarboxylase, and orotate phosphoribosyltransferase), bioA involved in biotin metabolism, and TonB-dependent receptor.