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ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF Delonix elata Linn.
Published in V. R. Mohan, A. Doss, P. S. Tresina, Ethnomedicinal Plants with Therapeutic Properties, 2019
Delonix regia (Hook.) Raf. is a species of small attractive tropical trees (Banks, 1997). It is commonly occurring flowering plant grown as an ornamental tree and given the name, flamboyant or flame tree, gulmohar, peacock, royal poinciana, etc. Till now even species were discovered in this genus, one occurs in Northeast Africa, nine species were found endemic in Madagascar and the remaining species occurs from East and Northeast Africa to India. Chemical constituents of different classes such as flavonoid, terpenoids and its glycosides, phenolics, and phytosterol (Shah et al., 2009; Jahan et al., 2010; Aly et al., 2011) were reported from flowers and leaves of this species. The flower was also used as natural color and as an acid–base indicator (Adje et al., 2008). The leaves are reported for its antimicrobial and antioxidant effect (Chou and Leu, 1992; Mariajancyrani et al., 2012). This study paves a new way of treatment of pain and inflammation with the extract of the leaves.
Enhanced oral delivery and anti-gastroesophageal reflux activity of curcumin by binary mixed micelles
Published in Drug Development and Industrial Pharmacy, 2019
Yongshun Sun, Yiping Li, Ying Shen, Jian Wang, Jian Tang, Zhiying Zhao
The physicochemical characteristics of CM-T and CM-F were evaluated. The CM-T solution was transparent and yellow, while interestingly, the CM-F solution was transparent and orange. After adjusting the pH to 6.5 with dilute hydrochloric acid, they all showed a pale yellow, this may be due to the fact that CM itself can act as an acid-base indicator that indicates the pH of the micelle solution. Analysis of the optimized CM-T and CM-F formulations showed that the final ratio of HS15 to TPGS was 50:10 (mg/mL) and of HS15 to F127 was 45:40 (mg/mL); their mean particle size diameters were 13.64 ± 0.46 and 15.95 ± 0.54 nm with acceptable PDIs of 0.176 ± 0.092 and 0.190 ± 0.015, respectively (Table 1). The zeta potential values of CM-T and CM-F were −0.598 ± 0.010 and −1.00 ± 0.008 mV, respectively. TEM showed that CM-T and CM-F were homogeneous and spherical (Figure 2). These findings show that the micelle systems CM-T and CM-F can effectively encapsulate CM into the core of micelles. While the apparent solubility of CM in CM-T and CM-F was dramatically increased to 1.68 and 1.74 mg/mL, which is a prerequisite for increasing the solubility of CM.