Veratrum nigrum

Veratrum nigrum

Substrates of Human CYP2D6

Published in Shufeng Zhou, Cytochrome P450 2D6, 2018

Veratramine, a steroidal alkaloid originating from Veratrum nigrum, has shown distinct antitumor and antihypertension effects. Unlike most alkaloids, the major reactive sites of veratramine are on rings A and B instead of on the amine moiety. CYP2D6 is the major enzyme mediating hydroxylation of veratramine (Lyu et al. 2015). SULT2A1 conjugates veratramine.

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway

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Journal Information

Published in Pharmaceutical Biology, 2022

Yu Zhang, Guangyao Ye, Yuebo Chen, Chaoxu Sheng, Jianlin Wang, Lingsi Kong, Liyong Yuan, Chunyan Lin

Veratrum nigrum Linn. (Melanthiaceae), a perennial herb, has a rich clinical history in Europe, Asia, and North America (Chandler and McDougal 2014). Dadix Veratri, mainly derived from Veratrum nigrum, is one of the primary components of the formulation of the traditional Chinese medicine of ‘Yunnan Baiyao’ and the main drug of the protected traditional Chinese medicine ‘Yizhi Zhitong Pill’. Veratramine is one of the main extracts of Dadix Veratri (Lyu et al. 2016). Veratramine is a known natural steroid alkaloid found in various Liliaceae plants (Li et al. 2019). Due to the vital role of Dadix Veratri in analgesia, we hypothesised that veratramine might also play an essential role in analgesia. Previous studies by Li et al. (2016, 2019) showed that veratramine has strong anti-inflammatory and analgesic effects. Although the authors demonstrated that the main analgesic ingredient of veratrum was veratramine (Li et al. 2016, 2019), they did not provide an in-depth discussion on the specific analgesic mechanism of veratramine.

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Substrates of Human CYP2D6

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway