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Chicken Pox/Varicella
Published in Charles Theisler, Adjuvant Medical Care, 2023
General Advice: Calamine lotion and a cool bath with added baking soda, aluminum acetate (e.g., Domeboro), oatmeal, or colloidal oatmeal may help relieve some of the itching. Antihistamines such as diphenhydramine (Benadryl, etc.) can also be used. Avoid aspirin and ibuprofen, if possible, in managing chickenpox symptoms. Tylenol can be used for mild fever.1,2
The work of physicians with individuals and communities: Epidemiology and other partners in evidence-based medicine
Published in Milos Jenicek, Foundations of Evidence-Based Medicine, 2019
EBM must be seen as a permanently evolving process in order to keep up with the pace of rapidly evolving experience and research production in health sciences. As an example, Aspirin may at first be considered the analgesic and/or antipyretic of choice for some patients. However, at a later time, because of Aspirin's adverse effects, the patients may be given Tylenol® instead.
When I Control the Pain, I Control My Life: Opioids and Opioid-Containing Analgesic Medication in the Management of Chronic Intractable Pain
Published in Michael S. Margoles, Richard Weiner, Chronic PAIN, 2019
A word of caution about Anexia 7.5® or other similar medications: Regular daily ingestion of more than 3.2 g of acetaminophen (Tylenol®) is not recommended. Anexia 7.5® has 500 mg of acetaminophen per tablet. Therefore, intake should not be in excess of five tablets per day. There are circumstances in which higher amounts of Tylenol® can be consumed, but the patient must be closely followed by the physician and by laboratory testing to assess for liver/kidney damage or clinical toxicity (Rose, 1996).
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series
Published in Clinical Toxicology, 2022
Stephanie L. Link, Garrett Rampon, Stephen Osmon, Anthony J. Scalzo, Barry H. Rumack
A 51-year-old woman with a history of end stage renal disease, diabetes mellitus, COPD, major depressive disorder, and intimate partner violence intentionally took 20–30 pills of Tylenol 325 mg tablets. The first APAP level was 313 mcg/mL which was approximately 4 h after ingestion. The patient received IV NAC at 150 mg/kg loading dose over 1 h followed by 12.5 mg/kg/hour at hour 6. At 16 h post ingestion she was administered a loading dose of fomepizole 15 mg/kg over 30 min. She underwent hemodialysis from hour 20 to 24 to aide with removal of APAP. At hour 27 she received a second bolus of fomepizole 10 mg/kg. Baseline transaminases were ALT 13 U/L and AST 16 U/L. Within 12 h of arrival or 16 h post-ingestion they had increased to 693 U/L and 1450 U/L for ALT and AST respectively. Her transaminases improved remarkably thereafter, and IV NAC was discontinued.
Delayed peaks of acetaminophen in overdose patients with concomitant abdominal trauma
Published in Clinical Toxicology, 2021
Elizabeth M. Crow, Meghan B. Spyres, Sean P. Boley, Michael Levine, Samuel J. Stellpflug
On arrival, her exam revealed wounds to all extremities, abdomen, back and thorax. Vital signs were temperature 36.0 C, heart rate 131 beats/minute, blood pressure 95/60 mmHg, respiratory rate 30 breaths/minute and oxygen saturation 100%. Her Glasgow Coma Scale (GCS) score was 15 on arrival, and her presentation did not support a classic ingestion toxidrome (i.e., anticholinergic or opioid related symptoms). The penetrating trauma resulted in a colon perforation, diaphragmatic injury, and pneumothorax. She demonstrated no signs or symptoms of a particular toxidrome. A chest tube was placed and she was taken to the operating room for a laparotomy. She reported being forced to ingest acetaminophen and methamphetamine and denied ethanol (these claims were supported by laboratory evaluation); the time frame of the ingestion is unknown, but likely within a few hours prior to presentation. The formulation of the acetaminophen was stated as simply “Tylenol”. Initial labs included an acetaminophen concentration of 211.7 mcg/mL and normal aspartate aminotransferase (AST), creatinine, pH, and coagulation studies. Two hours after arrival, 21-hour NAC protocol of 300 mg/kg was started intraoperatively and continued in the intensive care unit (ICU). No gastrointestinal decontamination was given.
Preclinical evaluation of a MAGE-A3 vaccination utilizing the oncolytic Maraba virus currently in first-in-human trials
Published in OncoImmunology, 2019
Jonathan G. Pol, Sergio A. Acuna, Beta Yadollahi, Nan Tang, Kyle B. Stephenson, Matthew J. Atherton, David Hanwell, Alexander El-Warrak, Alyssa Goldstein, Badru Moloo, Patricia V. Turner, Roberto Lopez, Sandra LaFrance, Carole Evelegh, Galina Denisova, Robin Parsons, Jamie Millar, Gautier Stoll, Chantal G. Martin, Julia Pomoransky, Caroline J. Breitbach, Jonathan L. Bramson, John C. Bell, Yonghong Wan, David F. Stojdl, Brian D. Lichty, J. Andrea McCart
For blood draws, injections and minor procedures, macaques were restrained on a purpose-designed chair. Animals were anesthetized for surgery by intramuscular administration of 50 μM/kg of Domitor for induction (Medetomidine hydrochloride, Novartis) then maintained with 1.0–2.5% isoflurane during the surgery. Buprenorphine (0.01–0.03 mg/kg) was administered intramuscularly every 12 hours, and acetaminophen (Tylenol®, 5–15 mg/kg) administered orally every 8–12 hours as needed for analgesia. A subcutaneous vascular access port (VAP) connected to a central venous catheter through the femoral vein was surgically implanted to facilitate MG1-MAGEA3 administration and blood sampling (CP4/PCP-4, Access Technologies, Norfolk Medical Products Inc., IL, USA). Primates were treated with the antibiotic enrofloxacin (Baytril®, Bayer Healthcare, ON, Canada) for 24 hours after the procedure. Animals were euthanized by exsanguination under deep anesthesia while being perfused with 1 L of normal saline. Craniotomy was conducted to expose the brain, and the brain was removed within minutes of death. Samples from specific regions were taken from one hemisphere and while the contralateral hemisphere was preserved intact and fixed in 10% neutral-buffered formalin.