China
Africa
Explore chapters and articles related to this topic
Complementary and Alternative Medicine Use in Rheumatic Disease
Published in Jason Liebowitz, Philip Seo, David Hellmann, Michael Zeide, Clinical Innovation in Rheumatology, 2023
Tripterygium wilfordii Hook F (TWHF), also known as thunder god vine, is found in China. In traditional Chinese medicine, it is used for swelling and inflammation.73 The herb has been demonstrated to have immunosuppressive and anti-inflammatory properties. However, this herb can be extremely poisonous if the extract is not prepared properly.
Decontextualised Chinese medicines
Published in Vivienne Lo, Michael Stanley-Baker, Dolly Yang, Routledge Handbook of Chinese Medicine, 2022
Michael Heinrich, Ka Yui Kum, Ruyu Yao
Several compounds from Chinese medicine are currently under development that may result in clinically approved medications for use in chronic inflammatory conditions. A decoction of Leigong teng 雷公藤, Radix Tripterygii wilfordii (Tripterygium wilfordii Hook.f.; Celastraceae), was first mentioned in the Supplement to the Systematic Materia Medica (Bencao gangmu shiyi 本草綱目拾遺 1765), the classic pharmacological encyclopaedia produced by Zhao Xuemin 趙學敏 (1719–1805 CE) during the Qing dynasty, but seems to be of limited importance in TCM today, due to toxicity problems.
The Role of Plant-Based Natural Compounds in Inflammation
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Marcela Dvorakova, Premysl Landa, Lenka Langhansova
A quinonic pentacyclic triterpenoid celastrol isolated from the roots of Tripterygium wilfordii Hook. F. and Celastrus sp. was studied for its ability to inhibit 5-LOX and COX-2 enzymatic activity in vitro. The obtained IC50 values were in a low to moderate range (5 µM for 5-LOX and 20 µM for COX-2). The inhibition of 5-LOX was determined in a cell-based assay, while the inhibition of COX-2 in a cell-free assay (Joshi et al., 2016).
Research progress of natural products and their derivatives against Alzheimer’s disease
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Jin-Ying Liu, Hong-Yan Guo, Zhe-Shan Quan, Qing-Kun Shen, Hong Cui, Xiaoting Li
Triptolide is an epoxy diterpene lactone and one of the main active components of Tripterygium wilfordii. Triptolide can inhibit the activation and proliferation of microglia and astrocytes in an APP/PS1 double-transgenic AD mouse model reduce neurotoxicity48. Furthermore, it was found to inhibit the expression of β-site amyloid precursor protein cleaving enzyme 1 and reduce Aβ production and deposition in the brain thus reversing the pathological changes in AD49. In vivo experiments have shown that triptolide increases the expression of insulin-degrading enzyme, a major Aβ-degrading enzyme in the brain50, which can reduce AD pathological symptoms by increasing Aβ degradation. A number of studies have confirmed that the natural product triptolide is an effective and multifunctional lead compound that can act on multiple targets relevant to AD and has the potential to be developed for the treatment of AD (Figure 7).
The mechanism of triptolide in the treatment of connective tissue disease-related interstitial lung disease based on network pharmacology and molecular docking
Published in Annals of Medicine, 2022
Wen Zhu, Yehui Li, Junjie Zhao, Yifan Wang, Yixi Li, Yue Wang
Tripterygium wilfordii is a clinically common Chinese herbal medicine, which has been used to treat clinical diseases for more than 2000 years in China. Because of its good immunosuppressive effect in the fields of metabolic diseases [9], kidney diseases [10], rheumatic diseases [11], inflammatory bowel diseases [12], and so on [13], Tripterygium wilfordii hance has been paid much attention by scholars at home and abroad. Triptolide is a major active natural product isolated from the medicinal plant Tripterygium wilfordii, which has exhibited to have good anti-inflammatory, immunosuppressive and anti-fibrosis therapeutic effects [9], but its molecular mechanism of action is still unknown. Network pharmacology is an emerging discipline based on the network of disease-gene-drug targets [14], based on network interaction to study the basic biological knowledge of TCM can provide a deep insight or scientific evidence for the discovery of TCM, and help us to clarify the pharmacological mechanism of active ingredients of TCM at the level of biomolecule [15]. Network pharmacology is gradually becoming a holistic and efficient tool to describe the complex interactions between drugs and biological systems including the human organs, diseases, metabolic pathways, and target proteins from a network perspective [16].
Mechanism of action of Tripterygium wilfordii for treatment of idiopathic membranous nephropathy based on network pharmacology
Published in Renal Failure, 2022
Honghong Shi, Yanjuan Hou, Xiaole Su, Jun Qiao, Qian Wang, Xiaojiao Guo, Zhihong Gao, Lihua Wang
Thunder god vine (Tripterygium wilfordii) is a well-known traditional Chinese medicine that has been widely used for the treatment of various autoimmune diseases, such as nephritic syndrome, inflammatory bowel disease, systemic lupus erythematosus, and rheumatoid arthritis [7]. Although T. wilfordii has some adverse events, such as hepatotoxicity, nephrotoxicity, and reproductive toxicity [8], clinical trials have demonstrated that T. wilfordii is effective for the treatment of IMN [9,10]. Guo et al. reported that T. wilfordii was effective for IMN patients with sub-nephrotic proteinuria, whether anti-PLA2R antibody is positive or negative [11]. And T. wilfordii was also more effective in preventing T cell proliferation and interferon-gamma production than FK506 [12]. Therefore, T. wilfordii can induce remission in patients who have no response to prednisone and calcineurin inhibitor. Compared with cyclophosphamide, the reproductive toxicity of T. wilfordii is reversible. In addition, T. wilfordii is inexpensive and available as a tablet. However, little is known about the molecular mechanisms underlying the effects of T. wilfordii on IMN.