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Global Regulation of Preservatives and Cosmetic Preservatives
Published in Philip A. Geis, Cosmetic Microbiology, 2020
The chemicals listed in Table 13.3 are permitted for use to treat acne under a final monograph issued on August 16, 1991. Benzyl Peroxide was changed from Category III to Category I in 2010.Topical Antifungal Drugs
Management of Fungal Keratitis
Published in Mahendra Rai, Marcelo Luís Occhiutto, Mycotic Keratitis, 2019
Mohammad Soleimani, Nader Mohammadi
In summary, administration of topical antifungal drugs is the first step of treatment. For this purpose, natamycin is an excellent choice for first-line therapy as a result of its good effect on fungal species involving keratomycosis. Other topical antifungal drugs (Topical amphotericin B 0.3 to 0.5% and voriconazole 1%) are considered as alternatives. Repeat culture was an essential prognosticator of clinical outcome and useful for evaluating response to treatment and guide therapy. IVCM provides valuable and objective information required in selecting and adjusting therapeutic regimens for the treatment of fungal keratitis. Therapeutic keratoplasty has an absolute role in the treatment of recalcitrant fungal corneal ulcers. The most useful role of TK is preventing the involvement of adjacent sclera and decreasing the risk of endophthalmitis.
Nanotechnological interventions in dermatophytosis: from oral to topical, a fresh perspective
Published in Expert Opinion on Drug Delivery, 2019
Riya Bangia, Gajanand Sharma, Sunil Dogra, Om Prakash Katare
Topical antifungals are regarded to be the first-line therapy for superficial dermatomycoses as they are highly efficacious and cause less systemic adverse effects. These drugs are formulated into umpteen varieties of vehicles, including creams, sprays, lotions, or gels. Their efficacy and penetrating ability depend on the site of involvement. On application to the surface of skin, they can permeate through the stratum corneum readily and can either inhibit the growth of fungi or kill them. The topical antifungal drugs are divided into major categories of the benzylamines, azoles, and allylamines [25]. For the therapy of cutaneous tinea, several topical creams have been used. Rotta et al. carried out a meta-analysis and observed that butenafine and terbinafine have better efficacy than clotrimazole, oxiconazole, and sertaconazole [26].
Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study
Published in Drug Delivery, 2018
Shaimaa El-Housiny, Maii Atef Shams Eldeen, Yasmina Ahmed El-Attar, Hoda A. Salem, Dalia Attia, Ehab R. Bendas, Mohamed A. El-Nabarawi
The drug delivery onto the skin is recognized as an effective means of local therapy for many dermatologic diseases (Kaur & Guleri, 2013). But the main obstacle facing the efficiency of topical antifungal drugs is the ability to penetrate the skin powerfully. Accordingly, the active material should pass in effective concentration through the stratum corneum, the first layer of the skin, to reach target tissue. Researchers may depend on pharmaceutical formulations as they exert a key role for permeation of drugs into skin. Development of novel approaches for local therapy of skin fungal infections utilizes advanced carrier systems for numerous compounds (Lee & Maibach, 2006). Nanoparticles are usually produced from natural/synthetic polymers with size range between 10 and 1000 nm. Therefore, they are suitable to optimize topical drug delivery and reduce toxicity (Mukherjee et al., 2009).
Clinical Investigation of the Safety and Efficacy of Low-temperature Plasma as an Adjuvant Treatment for Mild to Moderate Fungal Keratitis: A Pilot Study
Published in Ocular Immunology and Inflammation, 2023
Jingyi Cheng, Anji Wei, Jiaxu Hong, Jianjiang Xu
However, no study has assessed the safety and efficacy of LTP in the treatment of FK. Therefore, we conducted a pilot study to evaluate the safety and efficacy of LTP as an adjuvant therapy to topical antifungal drugs in patients with mild to moderate FK.