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Selected Botanicals and Plant Products That Lower Blood Glucose (Continued)
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
The Saudi Journal of Ophthalmology supplied the following information about some fruits that inhibit aldose reductase (Kaur, Gupta, Christopher et al. 2017): Belamcanda chinensis (blackberry): Tectoridin, tectorigeninMyrciaria dubia (Rumberry): Ellagic acidSyzygium cumini (jamun): Ellagic acidL. chinensis (lychee): Delphinidin 3-O-β-galactopyranoside-3′-O-β-glucopyranosideCitrus limon (lemon): RutinCitrus aurantium (orange): RutinPsidium guajava (guava): Quercetin derivativesMalus pumila (apple): Quercetin, epicatechin, procyanidinVitis vinifera (grapes): Citronellol
Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Tectoridin and tectorigenin isolated from the rhizome of Belamcanda chinensis (L.) Redouté given to streptozotocin-induced diabetic Sprague–Dawley rats orally at a dose of 100 mg/kg/day lowered sorbitol contents of lenses by 27.7% and 50.7%, respectively (epalrestat at 100 mg/kg/day: 57.7%).358In vitro, tectorigenin and tectoridin (Figure 5.32) inhibited rat aldose reductase with IC50 values of 1.1 and 1 µM, respectively.358 Iristectorigenin B isolated from rhizome at a concentration of 20 µM stimulated the transactivation of liver X receptor in cotransfected HEK293 cells in vitro.358 At a concentration of 10 µM, this isoflavone increased cholesterol efflux, lowered intracellular cholesterol concentration, and increased liver X receptor targets ATP-binding-cassette A1 and G1.359
Exploring the Plant Kingdom for Sources of Skincare Cosmeceuticals
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Wild Plants, 2020
Mayuri Napagoda, Sanjeeva Witharana
Moreover, tyrosinase inhibitory potential has been evaluated in numerous plant secondary metabolites by various research groups. Phenolic compounds and their derivatives, as well as some terpenoids, coumarins and quinones, have displayed strong tyrosinase inhibitory action. For example, an apigenin flavone glucoside vitexin and a C-glycosylflavone isovitexin isolated from Vigna radiata extracts inhibited the enzyme with IC50 values of 6.3 and 5.6 mg/mL, respectively (Yao et al. 2012). Also, significant inhibition of tyrosinase was observed in five flavones isolated from the stem barks of Morus lhou-viz., mormin (IC50 = 0.088 mM), cyclomorusin (IC50 = 0.092 mM), morusin (IC50 = 0.250 mM), kuwanon C (IC50 = 0.135 mM), and norartocarpetin (IC50 = 1.2 µM) (Ryu et al. 2008). Glabridin (IC50 = 0.43 µM), isolated from the root of Glycyrrhiza glabra has exhibited excellent inhibitory effects on tyrosinase (Chen et al. 2016), while Glyasperin C isolated from Glycyrrhiza uralensis also showed a strong tyrosinase inhibitory activity with an IC50 value of 0.13 µg/mL (Kim et al. 2005). The tyrosinase inhibitory studies on several other isoflavones, such as formononetin, genistein, daidzein, texasin, tectorigenin, odoratin, and mirkoin isolated from the stems of Maackia fauriei, revealed that, out of the above-isolated compounds, mirkoin (IC50 = 5 µM) possessed a stronger tyrosinase inhibition than the positive control kojic acid, and it could inhibit the enzyme reversibly in a competitive manner (Kim et al. 2010). In a recent study aimed at the screening of natural products for the development of cosmetic ingredients, two major compounds in Humulus japonicus, trans-N-coumaroyltyramine (IC50 = 40.6 µM) and cis-N-coumaroyltyramine (IC50 = 36.4 µM) displayed potent tyrosinase inhibition (Yang et al. 2018).
Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties
Published in Xenobiotica, 2021
Tectoridin, tectorigenin-4′-O-β-D-glucoside, iristectorin A, iristectorin B, iridin, and tectorigenin (≥98% pure) were obtained from Spring & Autumn Biological Engineering Co., Ltd. (Nanjing, China). HPLC-grade acetonitrile was obtained from Mallinckrodt Baker, Inc. (Phillipsburg, NJ, USA). HPLC–grade acetic acid (AS1102–002) was purchased from TEDIA, Inc (Fairfield, USA). Deionised water was prepared using a Millipore system (Millipore, MA, USA).
The metabolic effect of gut microbiota on drugs
Published in Drug Metabolism Reviews, 2020
Yuan Xie, Fangdi Hu, Dawei Xiang, Hui Lu, Wenbin Li, Anpeng Zhao, Longji Huang, Rong Wang
Tectoridin, an isoflavone isolated from the flower of Pueraria thunbergiana, can be metabolized to its aglycone, tectorigenin, by human fecal suspensions (Shin et al. 2006). Tectoridin has estrogen activity and antiallergic activity. However, tectorigenin exhibits more potent antioxidant activity and inhibiting ability on prostaglandin E2 production than tectoridin (Kim et al. 1999; Han et al. 2012).
MicroRNAs in idiopathic pulmonary fibrosis, new research progress and their pathophysiological implication
Published in Experimental Lung Research, 2018
Chenggui Miao, Youyi Xiong, Guoxue Zhang, Jun Chang
Tectorigenin, a natural plant active ingredient, inhibits the abnormal proliferation of pulmonary fibroblasts in vitro and enhances the miR-338* expression that might in turn inhibits the LPA1.68 Thus tectorigenin may be a potential IPF therapeutic drug, worthy of further clinical research.