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The Potential of Microbial Mediated Fermentation Products of Herbal Material in Anti-Aging Cosmetics
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Biotransformation may also constitute the conversion of an active metabolite to a more active metabolite, as in the instance of tectoridin to 6-hydroxygenistein and kakkalide to 6-hydroxybiochanin (Figure 2.3). This is referred to as bioactivation. Tsuchihashi et al. (2009) cultured Peptostreptococcus productus with tectoridin and kakkalide isoflavones from Pueraria flowers, which yielded 6-hydroxygenistein and 6-hydroxybiochanin A, respectively. While tectoridin and kakkalide did not show any hepatoprotective activity (EC50 > 200 µM), 6-hydroxygenistein and 6-hydroxybiochanin A showed significant activity, producing EC50 values of 18.3 µM and 14.5 µM, respectively (Tsuchihashi et al., 2009).
Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Tectoridin and tectorigenin isolated from the rhizome of Belamcanda chinensis (L.) Redouté given to streptozotocin-induced diabetic Sprague–Dawley rats orally at a dose of 100 mg/kg/day lowered sorbitol contents of lenses by 27.7% and 50.7%, respectively (epalrestat at 100 mg/kg/day: 57.7%).358In vitro, tectorigenin and tectoridin (Figure 5.32) inhibited rat aldose reductase with IC50 values of 1.1 and 1 µM, respectively.358 Iristectorigenin B isolated from rhizome at a concentration of 20 µM stimulated the transactivation of liver X receptor in cotransfected HEK293 cells in vitro.358 At a concentration of 10 µM, this isoflavone increased cholesterol efflux, lowered intracellular cholesterol concentration, and increased liver X receptor targets ATP-binding-cassette A1 and G1.359
Tectoridin alleviates lipopolysaccharide-induced inflammation via inhibiting TLR4-NF-κB/NLRP3 signaling in vivo and in vitro
Published in Immunopharmacology and Immunotoxicology, 2022
Xiaofeng Niu, Huixin Song, Xin Xiao, Jinjin Yu, Jiabao Yu, Yajie Yang, Qiuxia Huang, Lulu Zang, Tengfei Han, Dezhu Zhang, Weifeng Li
Frog seven (Iris tectorum Maxim) is an ornamental Chinese herbal medicine for the treatment of sore throat, pharyngitis, and cough [22]. Isoflavone is the most effective component in its rhizome. Tectoridin (structure shown in Figure 1(A)), the major isoflavone in the iris, plays an important role in many pharmacological actions. Previous studies have shown that tectoridin provided anti-inflammatory, estrogenic, hepatoprotective, and antioxidant activities in vivo and in vitro [23–25]. Moreover, tectoridin also showed a potent protective effect on ethanol-induced liver steatosis in mice [26], and osteoporosis and other bone diseases in recent years [27]. Nevertheless, whether tectoridin modulates LPS-induced inflammation and endotoxin shock remains unclear. The present research was thus created to investigate the anti-inflammatory effects of tectoridin in vivo and in vitro and the underlying mechanism. The results of this study showed that pretreatment with tectoridin could inhibit LPS-induced inflammatory response in vivo and in vitro by inhibiting TLR4-NF-κB/NLRP3 signaling pathway.
Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties
Published in Xenobiotica, 2021
Prior studies of the phytochemical compounds within I. tectorum Maxim have revealed that it includes isoflavones (Zhang et al. 2016a), C-glycosylflavones (Ma et al. 2012), triterpenoids (Takahashi et al. 2000, Fang et al. 2007, Zhang et al. 2014, 2015b, 2017a, 2017b), lignans (Zhang et al. 2016b), and apocynin derivatives (Zhang et al. 2017c), with HPLC-MS/MS analyses having also been used to identify the chemical components of I. tectorum Maxim (Shu et al. 2010, Xie et al. 2014, Gao et al. 2021). To date, a limited number of pharmacokinetic studies of tectorigenin and tectoridin in rat plasma have been conducted following oral I. tectorum Maxim extract, tectorigenin, and tectoridin administration (Chen et al. 2008, Zhang et al. 2011, Qu et al. 2012, Bai et al. 2014, Yang et al. 2015). Network pharmacology strategies have previously been employed to characterise molecular interactions between the bioactive components of traditional Chinese medicines and their putative targets via mapping compound-targeted disease networks at the biological level (Li and Zhang 2013). Molecular docking approaches have been used to validate interactions between these components and their targets. However, few studies have utilised HPLC-Q-TOF-MS approaches to comprehensively identify I. tectorum Maxim in vivo metabolites, then employing network pharmacology and molecular docking strategies to predict and verify interactions between these metabolites and their targets.
The metabolic effect of gut microbiota on drugs
Published in Drug Metabolism Reviews, 2020
Yuan Xie, Fangdi Hu, Dawei Xiang, Hui Lu, Wenbin Li, Anpeng Zhao, Longji Huang, Rong Wang
Tectoridin, an isoflavone isolated from the flower of Pueraria thunbergiana, can be metabolized to its aglycone, tectorigenin, by human fecal suspensions (Shin et al. 2006). Tectoridin has estrogen activity and antiallergic activity. However, tectorigenin exhibits more potent antioxidant activity and inhibiting ability on prostaglandin E2 production than tectoridin (Kim et al. 1999; Han et al. 2012).