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Evaluation of Anti-ulcer Potential of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir Leaves on Various Gastric Aggressive Factors
Published in Parimelazhagan Thangaraj, Phytomedicine, 2020
P. S. Sreeja, K. Arunachalam, Parimelazhagan Thangaraj
Even though there are hundreds of compounds isolated from plants with medicinal properties, some compounds, like taspine, isolated from Croton lechleri, has both anti-inflammatory property by reducing the inflammatory process, as well as gastroprotection property by reducing the H. pylori bacteria content in the stomach. Thus Taspine demonstrates that it has multitargets of the therapeutic property for curing diseases and, hence, it is able to be used for more than one illness, both anti-inflammatory, as well as gastroprotection. In same way, the compound colchicine derived from Colchicum luteum possesses anti-inflammatory activity, pain relieving effects on joints and relief from bronchial diseases; salicin from the plant Salix alba proves to have analgesic and anti-rheumatic properties, and is also a proven febrifuge; marrubiin obtained from the plant Marrubium vulgare demonstrated anti-nociceptive and vasorelaxant activity; and glycirrhizin derived from the plant Glycyrrhiza glabra can be used as an expectorant and also for duodenal ulcer and inflammation treatment (Sultan et al. 2013; Jain 2016; Uritu et al. 2018).
Nutraceuticals Impacting Uterine Growth, Gestational Age and Mortality Rate
Published in Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, Yashwant Pathak, Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, 2019
Shrushti Patil, Natalia Mercado, Yashwant Pathak, Priyanka Bhatt
Native Americans have a long history of using blue cohosh for gynecological issues. Blue cohosh is found in a variety of forms in North America. Black cohosh is often used in conjunction with blue cohosh, which has been known to have oxytocic and abortifacient effects. According to a survey conducted for certified nurse-midwives, this labor-inducing herb has caused complications in about 21% of cases (Irikura & Kennelly 1999). These complications included nausea, meconium-stained fluid, and transient fetal tachycardia. The amount of glycosides—caulosaponin and caulophyllosaponin—present in blue cohosh were the main reason for its oxytocic effects. Moreover, there have been findings of some seriously toxic alkaloid extracts in blue cohosh, namely: Anagyrine—hazardous if present in a concentration of 290 ppm, this teratogen is found in grazing animals and causes congenital deformations. Its activity in humans is not known at this time, but the FDA discourages the consumption of anagyrine at any concentration.N-methylcytisine—hazardous if present in a concentration of 20 ppm, this potentially harmful chemical has caused malformation in rat embryos, has restricted growth, and caused morphogenesis in the embryos. It has an effect similar to nicotine.Taspine—hazardous if present in a concentration of 0.5 ppm, this compound has been known to kill rat embryos at a concentration of 5 ppm. It is highly cytotoxic and a possible human teratogen (Irikura & Kennelly 1999).
TPD7 inhibits the non-small cell lung cancer HCC827 cell growth by regulating EGFR signalling pathway
Published in Journal of Chemotherapy, 2022
Xiaoyan Zhang, Hongjun Zhang, Gangqiang Qi, Xing Gu, Yanjun Zhao, Jie Zhang
Natural products have been used as source of novel therapeutics. The diversity of chemical structure makes them attractive as lead structures for discovery of new drugs [10]. Taspine, isolated from the medicinal plant such as Radix Aconitum, Croton Lechleri, and etc., is a member of natural products with extensive pharmacological activities, including the inhibition of bacteria, angiogenesis and malignant tumours [11–14]. Studies reported that taspine showed effective anti-tumour activity, such as human breast cancer [15], epidermoid carcinoma [16], and lung cancer [17]. TPD7 is a new taspine derivative (Figure 1A) with increased solubility compared with taspine, and has been shown to inhibit cancer cell growth by targeting VEGFR2, EphrinB2, IL-2R, Fas, and CXCR4 [18–21]. In this study, we found that TPD7 showed selective inhibitory effect on HCC827 cell growth through suppressing proliferation, arresting cell cycle and inducing cell apoptosis, and the underlying mechanism involves to suppression of EGFR signalling pathways.