China
Africa
Explore chapters and articles related to this topic
Herbal Drug Discovery Against Inflammation: From Traditional Wisdom to Modern Therapeutics
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Shalini Dixit, Karuna Shanker, Madhumita Srivastava, Priyanka Maurya, Nupur Srivastava, Jyotshna, Dnyaneshwar U. Bawankule
Parthenolide are isolated from Tanacetum parthenium L and are major sesquiterpenes lactones. Commonly occurs in leaves and flower heads of feverfew. Tanacetum parthenium is locally used by Mexican Indians for infectious diseases for a long time. Its methylene γ-lactone ring epoxide group has neuclophillic nature which enables its fast interaction with the receptor. The interaction between these sites and the receptors can induce oxidative stress and also shows anticancer properties (Mathema et al., 2012; Jain and Kulkarni, 1999; Li et al., 2002).
Migraine: diagnosis and treatment
Published in Stephen D. Silberstein, Richard B. Upton, Peter J. Goadsby, Headache in Clinical Practice, 2018
Stephen D. Silberstein, Richard B. Upton, Peter J. Goadsby
Feverfew (Tanacetum parthenium) is a medicinal herb used by some patients to self-treat migraine. The clinical effectiveness of feverfew for migraine prevention has not been established beyond reasonable doubt. More clinical trials are needed, both on a larger scale and with various feverfew extracts, including parthenolide-free sesquiterpene lactone chemotypes.122
Migraine: Management and Treatment with Herbal Drugs
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Arulmozhi D. Kandasamy, Yogesh Anant Kulkarni, Addepalli Veeranjaneyulu, Ram S. Gaud
Phytomedicine has offered alternative source of therapy for migraine sufferers, and provided some additional information about the pathogenesis of migraine.13,14 Feverfew (Tanacetum parthenium) and butter bur (Petasites hybridus) are some of the plants that have been used for centuries for relief of migraine.15,16 Many plants like “Sapindus trifoliatus” have been studied scientifically for their effects in migraine.17–19
Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief
Published in Temperature, 2023
Luigi F. Iannone, Romina Nassini, Riccardo Patacchini, Pierangelo Geppetti, Francesco De Logu
Regarding herbal products, Tanacetum parthenium (feverfew) and Petasites hybridus Gaertn (butterbur) have been used for centuries to treat migraine and other pain conditions. Some preparations containing parthenolide (a feverfew constituent) and butterbur (in particular, its components, petasin and isopetasin) are or have been used for migraine prophylaxis [116]. In rodents, parthenolide and isopetasin behave as TRPA1 partial agonists [61,117] with an initial activation followed by prolonged concentration- and dose-dependent specific TRPA1 desensitization and nonspecific desensitization of peptidergic nociceptors, which express the channel [61]. In this manner, nociceptor nerve fibers became unresponsive to any stimulus, and unable to release CGRP from their terminals, including those present in the trigeminovascular system. Finally, a compound contained in plants largely used in traditional medicine, ligustilide, has been identified as a TRPA1 partial agonist, with a certain degree of inhibitory activity on mustard oil activated currents in the dural [118].
Targeting Major Signaling Pathways of Bladder Cancer with Phytochemicals: A Review
Published in Nutrition and Cancer, 2021
Connor Chestnut, Dharmalingam Subramaniam, Prasad Dandawate, Subhash Padhye, John Taylor, Scott Weir, Shrikant Anant
Parthenolide occurs naturally in the feverfew herb (Tanacetum parthenium), which has been used in European folk medicine to treat ailments ranging from migraine headaches to dysmenorrhea (208). Parthenolide is an esquiterpene lactone and has been investigated in pre-clinical trials for treatment of both solid and hematogenous tumors (186). Shanmugam showed In Vivo that the water-soluble parthenolide analogue dimethylaminoparthenolide (DMAPT) inhibits BC cell proliferation through induction of oxidative stress, inhibition of NF-κB signaling, and induction of JNK (209). Cheng et al. showed In Vitro that parthenolide inhibits proliferation, induces apoptosis, and causes G1-phase arrest in BC cell lines (210). Western-blot analysis revealed that parthenolide achieved these effects through PARP activation and downregulation of Bcl-2 (210).
The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Xin Jin, Jianping Zhou, Zhenhai Zhang, Huixia Lv
Several natural antitumor products have been used clinically including paclitaxel, cantharidin, vincristine, and arsenic trioxide. Although these have all exhibited antitumor effects, serious side effects have restricted their application. Even targeted preparations of these compounds may exhibit some side effects [4,5]. Natural products with lower levels of toxicity have now been investigated, including parthenolide, ginsenoside compound K (CK, as shown in Figure 1(A)), ginsenoside Rh2, ginsenoside Rg3, artemisinin, and curcumin [6,7]. Parthenolide (as shown in Figure 1(A)) is the main active compound of Tanacetum parthenium, which is widely applied in Mexico and India, and has recently been employed as an antitumor agent [8–15]. The antitumor effects of parthenolide involved suppression of the B-Raf/mitogen-activated protein kinase pathway [16], blockade of nuclear factor-κB activation [17], and inhibition of phosphoinositide 3-kinase/protein kinase B signaling [18]. Panax ginseng C. A. Meyer has been used for nearly 5000 years in oriental medical traditions and more recently in western medicine [19]. As the major active compound present in ginseng, CK can block glycogen synthase kinase 3β signaling [20], inhibit sphingosine kinase-1 [21], decrease the levels of reactive oxygen species [22], and increase the cisplatin sensitivity of cancer cells when co-administered with cisplatin [23].