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Nutraceutical Herbs and Insulin Resistance
Published in Robert E.C. Wildman, Richard S. Bruno, Handbook of Nutraceuticals and Functional Foods, 2019
Giuseppe Derosa, Pamela Maffioli
Syzygium cumini (L.) Skeels belongs to the Myrtaceae family, and it has been intensively studied as an antidiabetic agent and has often been recommended as an adjuvant for the treatment of type 2 diabetes mellitus. In Brazil, most people use an infusion or decoction of dry leaves in an average dilution of 2.5 g/L (0.2–6.9) for Syzygium cumini.82 Moreover, experimental data revealed the potential hypoglycemic activity of leaf extract,83,84 seed, and bark extracts85 and also seed kernels and fruits of Syzygium cumini.86
Recent Insights on the Role of Natural Medicines in Immunostimulation
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Isabella Muscari, Sabrina Adorisio, Trinh Thi Thuy, Tran Van Sung, Domenico V. Delfino
Syzygium cumini (also known as jamun). Used in traditional Indian medicine, S. cumini leaf extracts protect lymphocytes against radiation-induced DNA damage and suppress radiation-induced lipid peroxidation and DNA damage in the spleen of mice (Kim et al. 2017).
Syzygium cumini in Ayurveda and Other Traditional Medicare Systems in India
Published in K. N. Nair, The Genus Syzygium, 2017
S. Rajasekharan, Vinodkumar T. G. Nair
Syzygium cumini is an important medicinal plant used in both CHT and LHT of India. According to Ayurveda, this medicinal tree is known as jambavam in Sanskrit, the official language of India in earlier times. The tree was widely distributed in ancient India and was in those days popularly known as jamboo, which means a tree where flowers and fruits are available irrespective of seasons. History reveals that people first located this tree species in the south of Mahameru and described the indigenous taxonomical features of the tree. In Purana, S. cumini is considered one of the divine trees (mahavriksha) on earth. Other mahavrikshas are kadamba (Neolamarckia cadamba), peral (Ficus benghalensis), and makanda (Mangifera indica).
Synthesis of silver nanoparticles using Ziziphus nummularia leaf extract and evaluation of their antimicrobial, antioxidant, cytotoxic and genotoxic potential (4-in-1 system)
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2021
Hemali Padalia, Sumitra Chanda
DPPH activity was found to increase in a dose-dependent manner. The IC50 value of AgNPs was 520 µg/mL (Figure 7(A)). Kanipandian et al.[17] reported DPPH free radical scavenging activity of AgNPs synthesized from Cleistanthus collinus, 69% inhibition at a concentration of 1000 µg/mL however the activity was quite less as compared to the present results; the synthesized AgNPs showed 88% inhibition at concentration of 960 µg/mL. ABTS radical cation scavenging activity was also dose dependent, IC50 value of synthesized AgNPs was 55 µg/mL (Figure 7(B)).Nagajyothi et al., [26] also reported dose-dependent ABTS radical cation scavenging activity for AgNPs synthesized using Inonotus obliquus extract. The reducing capacity of AgNPs showed a steady increase in the absorbance of the reaction mixture with increase in concentration of AgNPs (Figure 7(C)). Similar results are reported by [5] for AgNPs synthesized using Syzygium cumini seed extract.
Phenolic extract of Eugenia uniflora L. and furanone reduce biofilm formation by Serratia liquefaciens and increase its susceptibility to antimicrobials
Published in Biofouling, 2020
Adeline Conceição Rodrigues, Felipe Alves de Almeida, Cleriane André, Maria Cristina Dantas Vanetti, Uelinton Manoel Pinto, Neuza Mariko Aymoto Hassimotto, Érica Nascif Rufino Vieira, Nélio José de Andrade
Gopu et al. (2015b) also reported a synergistic effect between fruit extract of Syzygium cumini (L.) Skeels and antibiotics, such as ofloxacine or tetracycline or chloramphenicol against K. pneumoniae PUFST23. The leaf methanolic extract of Allium cepa combined with amicanine showed a synergistic effect against E. coli, but the combination of this antibiotic with the hexane extract showed an antagonistic effect (Cruz et al. 2016). On the other hand, combinations of isoquercetin with either kanamycin, amikacin, neomycin or gentamicin against E. coli presented antagonistic effects, where there was an increase in MICs for the antibiotics tested (Veras et al. 2011). The combination of quercetin and kanamycin showed a partial synergistic effect against K. pneumoniae PUFST23 and with ampicillin it showed a synergistic effect against Y. enterocolitica PUFSTb09 (Gopu et al. 2015a). Cyanidin combined with kanamycin showed an additive effect against K. pneumoniae PUFST23 (Gopu and Shetty 2016).
Protein tyrosine phosphatase 1B (PTP1B) inhibitors as potential anti-diabetes agents: patent review (2015-2018)
Published in Expert Opinion on Therapeutic Patents, 2019
Hidayat Hussain, Ivan R Green, Ghulam Abbas, Sergazy M Adekenov, Wahid Hussain, Iftikhar Ali
Phloroglucinol analogs are phenolic compounds distributed in various natural sources and these compounds are reported to have antidiabetic effects [25]. Phloroglucinols 30–43 were reported from Syzygium cumini [26] and interestingly S. cumini has been used since the mid-nineteenth century to treat diabetes [27]. In this regard, phloroglucinols 30–43 (Figure 3) demonstrated significant PTP1B effects with IC50 ranging from 0.42 to 2.67 μM [26]. It is noteworthy that compounds 30 and 34 having R1 and R2 = H and the C-2 side chain having 17 carbon atoms, showed better activities with IC50 of 0.45 and 0.42 μM respectively. On the other hand activity was decreased when R1 (C-6) = R2 (C-8) = Me as demonstrated by compounds 31 and 35 which showed inhibition of IC50 of 1.57 and 2.67 μM respectively.