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Medicinal Plants Against COVID-19
Published in Hanadi Talal Ahmedah, Muhammad Riaz, Sagheer Ahmed, Marius Alexandru Moga, The Covid-19 Pandemic, 2023
Binish Khaliq, Naila Ali, Ahmed Akrem, M. Yasin Ashraf, Arif Malik, Arifa Tahir, M. Zia-Ul-Haq
Garlic is another herbal food medicine since ancient times. It was observed that fresh crushed garlic can be used with honey to enhance the immunity and also have the antimicrobial and antiviral activity. Cloves of garlic contain the several bioactive sulfur compounds, i.e., polyphenols, sulfoxide, and proteins [135, 151]. In some studies garlic show the positive significant effect on the immune cells, for example sulfur compounds such as allyl methyl sulfide, diallyl sulfide and diallyl disulfide showed the immunostimulatory reaction in mice [152]. Diallyl disulfide sulfur compound shows very good results as compared to other sulfur compounds. This compound increased the white blood cells (WBC) and antibody in mice. Sulfur containing compounds increased the quantity of spleen plaque forming cells, raised the cellularity of bone marrow and increased the positive cells of α-esterase. However, modulatory effects were observed on T lymphocyte and macrophage function by protein faction and garlic extract.
High Consumption of Herbs, Spices, and Garlic
Published in John J.B. Anderson, Marilyn C. Sparling, The Mediterranean Way of Eating, 2014
John J.B. Anderson, Marilyn C. Sparling
Garlic, a bulbous, aromatic herb of the lily family, has been used widely for centuries in many Mediterranean cuisines It continues to be a highly valued addition to Mediterranean cuisines, both for the unique flavor it imparts to many dishes as well as for its possible therapeutic qualities Allium vegetables, such as garlic, onions, shallots, leeks, and chives, are high in sulfur compounds, which give them their distinctive aroma and taste A sulfur compound in garlic, allicin, is thought to offer health benefits for diabetes, cardiovascular diseases (CVDs), certain cancers, and other chronic diseases In addition to allicin, garlic contains many other compounds that also may confer positive health effects Evidence from some studies indicates that garlic consumption may increase secretion of insulin from B cells in the pancreas, as well as play a role in the prevention of obesity Promising effects of garlic concerning cardiovascular health have been shown in a number of studies and meta-analyses Findings suggest garlic to be effective in reducing total serum cholesterol and low-density lipoprotein (LDL) cholesterol as well as lowering blood pressure.
Inhibitory effect of Tunceli garlic (Allium tuncelianum) on blastocystis subtype 3 grown in vitro
Published in Expert Opinion on Orphan Drugs, 2020
Mehmet Aykur, Emrah Karakavuk, Muhammet Karakavuk, Mesut Akıl, Hüseyin Can, Mert Döşkaya, Yüksel Gürüz, Hande Dağcı
Garlic is one of the oldest medicines in the world used for medicinal purposes. It was shown by Pasteur to have an anti-bacterial effect, and then garlic was used in the treatment of gangrene during World Wars [58]. It has also been used as a medicinal plant for various biological activities, including anti-carcinogenic, antithrombotic, antimicrobial, anti-inflammatory, and antioxidant effects [59]. The medicinal effect of garlic is largely associated with the allicin, a sulfur compound. In addition, it contains many other complex components [60]. The antiparasitic effects of some components of garlic were investigated in Entamoeba histolytica, Giardia intestinalis, and trypanosomes [61,62]. In our study, it was found that A. tuncelianum extract had anti-Blastocystis effect against Blastocystis ST3 strain.
Quantitative proteomics reveals the mechanisms of hydrogen-conferred protection against hyperoxia-induced injury in type II alveolar epithelial cells
Published in Experimental Lung Research, 2018
Xue Lu, Chao Wang, Dan Wu, Chao Zhang, Changxue Xiao, Feng Xu
Among the proteins differentially expressed between the hyperoxia and hydrogen plus hyperoxia groups, the top 10 most highly enriched biological processes terms included regulation of cell proliferation, protein metabolic process, response to lipids and steroid hormones. The majority of enriched molecular functions were related to sulfur compound binding, heparin binding, glycosaminoglycan binding, insulin-like growth factor binding, and superoxide-generating NADPH oxidase activator activity (Figure 4B and Supplemental Table 3).[12] PPI network analysis showed that these proteins were closely associated with the metabolism of xenobiotics by cytochrome p450, complement and coagulation cascades, glutathione metabolism, and microRNAs in cancer (Figure 5B). Proteins annotated to regulation of cell proliferation process included VEGFA (vascular endothelial growth factor A), PDGFB (platelet-derived growth factor subunit B), IGFBP3 (insulin-like growth factor-binding protein 3), and EDN1 (endothelin-1), and others (Supplemental Table 3).[12]
Concentration-time extrapolation of short-term inhalation exposure levels: dimethyl sulfide, a case study using a chemical-specific toxic load exponent
Published in Inhalation Toxicology, 2018
Eugene Demchuk, Shannon L. Ball, San L. Le, Andrew J. Prussia
Similar to hydrogen sulfide (HS) and methyl mercaptan (MM), DMS is a volatile sulfur compound. Therefore, its properties are similar but non-identical to those of HS and MM. Comparison of AIHA’s Emergency Response Planning Guideline (ERPG) values for DMS with Acute Exposure Guideline Levels (AEGLs) for 1-hour exposures of HS and MM suggests that DMS causes specified health effects at concentrations higher than the latter ones. Neither ERPGs nor AEGLs provide guidance for DMS at other exposure durations. However, its mode of action (MOA), in many respects, resembles that of these structurally similar (Figure 1) and more amply studied congeners with a better understood MOA (Almeida et al. 2008).