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Principles of Radioiodination and Iodine-Labeled Tracers in Biomedical Investigation †
Published in Garimella V. S. Rayudu, Lelio G. Colombetti, Radiotracers for Medical Applications, 2019
Mrinal K. Dewanjee, Shyam A. Rao
Because of its low cost, availability, high photon yield, and low radiation dose, 99mTc-sodium pertechnetate has been used increasingly as an agent for thyroid imaging and thyroid function. Because pertechnetate and iodide ion have similar charge and ionic radius, pertechnetate mimics radioiodide, although the uptake is lower and there is no organification of pertechnetate; occasionally, there may be differences between 99mTc image (trapping) and 131I image (trapping and organification in thyroid hormone).131
Radiopharmaceuticals
Published in Mario P. Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990
Use — Sodium pertechnetate (99mTc) is used for scintigraphy, particularly of the brain and thyroid. It can also be used to prepare various technetium-99m labeled radiopharmaceuticals for selective organ imaging, especially of the liver, lung, bone, kidney, and brain.
Undernutrition – thirty years of the Regional Basic Diet: the legacy of Naíde Teodósio in different fields of knowledge
Published in Nutritional Neuroscience, 2022
Larissa B. Jannuzzi, Amaury Pereira-Acacio, Bruna S. N. Ferreira, Debora Silva-Pereira, João P. M. Veloso-Santos, Danilo S. Alves-Bezerra, Jarlene A. Lopes, Glória Costa-Sarmento, Lucienne S. Lara, Leucio D. Vieira, Ricardo Abadie-Guedes, Rubem C.A. Guedes, Adalberto Vieyra, Humberto Muzi-Filho
This section finally reviews a small, though important ensemble of data demonstrating raising the questions about RBD over a wide range of scientific fields. Teodósio’s group [63] addressed the simple question as to how long a rodent that was undernourished during all its life can live. Besides programming specific morbidities, they demonstrated that RBD-induced intrauterine undernutrition reduced the life expectancy of adult rats, which had remained an unanswered question by the end of the last century. One might propose that the same applies to human beings. Focusing on the respiratory system, Barbosa et al. [64] showed that rats exposed to perinatal undernutrition (intrauterine and during lactation), followed by consumption of a high-fat diet after weaning to 90 days of age resulted in a higher volume of air displaced in each normal respiratory cycle; therefore, there was an increased risk of pulmonary barotrauma and impairment of cardiac function. Since the rats normonourished during the entire perinatal window had normal respiratory function after exposure to the high-fat diet, it became clear that perinatal programming by RBD might lead to changes in lungs after induction of overweight by a high-fat diet after weaning, with altered respiratory function. Finally, Passos et al. [65] using a radiopharmaceutical drug showed that undernutrition during the young adult life of Wistar rats specifically decreased thyroid accumulation of sodium pertechnetate (Na99TcmO4), a medicinal radiocompound used in thyroid scintigraphy and other nuclear medicine procedures.
Effect of toxoplasmic infection on the biodistribution of a brain radiopharmaceutical
Published in International Journal of Radiation Biology, 2019
João Cláudio da Costa Urbano, Ranny Beatriz de Carvalho Holanda Leite, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Joelma Maria de Araújo Andrade, Cláudio Bruno Silva de Oliveira, Vanessa Santos de Arruda Barbosa, Valter Ferreira de Andrade-Neto, Cecília Maria de Carvalho Xavier Holanda
Mice were randomly divided into 3 groups of 6 animals each: one control group (C), one only infected group (I), and one infected and treated group (IT). The group C received only 0.5 ml of distilled water, by intragastric gavage, for 10 days and in the 10th day received, after anesthesia, 0.1 ml of the radiopharmaceutical 99mTc-ECD via femoral vein. The technetium-99m, of which the radiochemical purity is 95%, was eluted from a generator of molybdenium generator-99 and technetium-99m (99Mo/99mTc) in the form of sodium pertechnetate (Na99mTcO4−), produced by the Institute of Energy and Nuclear Research of São Paulo/Brazil and gently supplied by the Norteriograndense League against Cancer, Natal/RN, Brazil, together with the ECD kit.
Phase transition of a microemulsion upon addition of cyclodextrin – applications in drug delivery
Published in Pharmaceutical Development and Technology, 2018
Sachin S. Thakur, Jared Solloway, Anneloes Stikkelman, Ali Seyfoddin, Ilva D. Rupenthal
ME-1 formulation was subsequently promoted to ex vivo clearance studies. ME-1 on its own demonstrated significantly greater retention than the simple solution, with the latter rapidly draining off the tissue surface (Figure 7). Ten minutes following instillation 17.11 ± 0.95% of the original fluorescent signal from ME-1 remained on the tissue as opposed to 4.69 ± 0.94% from the fluorescein solution (p < .01). This finding is unsurprising as it is understandable that increased viscosity would prolong formulation residence. Previous reports have demonstrated that o/w emulsions and w/o ME could maximize the AUC of retention but did not prolong the residence of sodium pertechnetate (99mTc) in a similar in vivo rabbit model (Alany et al. 2006). In our case, both retention AUC and amount significantly increased. Possible reasons for the discrepancy here may relate to the differences in constituents employed to prepare the formulations.