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Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Sesame seed is the seed of the plant Sesamum indicum, family Pedaliaceae. Similar to flaxseed, sesame seed is rich in oil, omega-3 alpha-linolenic acid, omega-6 fatty acids, vitamin E, fibers, phytic acid, proteins, and minerals. Sesame seeds and oil also contain a lot of lignans (non-flavonoid polyphenols), particularly sesamin and sesamolin, substances that may help lower blood cholesterol levels, and may have antihypertensive, immunoregulatory, anticarcinogenic, and anti-aging activities (156–157). Sesame seeds and oils might prevent some cardiac diseases and inflammation such as atherosclerosis and arthritis (156–157). However, sesame seed and oil can cause allergy, including anaphylaxis. Sesame seed and oil are used as ingredients in various cuisines in the world (Mexico, Eastern Asia, Middle Eastern, etc.).
Perspectives of Nature-Oriented Pharmacotherapeutics for the Effectual Management of Hemorrhoidal Symptoms
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Taranpreet Kaur Bamrah, Mojabir Hussen Ansari, Debarshi Kar Mahapatra
The seeds of Sesamum indicum L. (Pedaliaceae) are extremely useful in treating hemorrhoids, constipation, pain, and wound healing. They can be taken in the form of a decoction by boiling 20 g of seeds in water till it is reduced by one-third of the quantity, or as sweetmeats. They can also be given with butter, ground to paste with water, and applied over bleeding hemorrhoids.
G
Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Gingili Oil Sesame oil, mentioned in ancient Sanskrit, Hebrew, Egyptian, Greek and Roman literature. It is referred to as semsent in the Ebers papyrus and the term tila appears in Ayurvedic literature. Sesamum indicum, the plant from which the seeds for the oil are obtained, is indigenous to India. It was cultivated in Cyprus, Egypt and Sicily during the Middle Ages. A picture is given in Hortus Medicus et Philosophicus written by a physician and botanist, Joachum Camirarius (1530–1598) of Nuremburg, in 1568.
Sesamol Augments Paclitaxel-Induced Apoptosis in Human Cervical Cancer Cell Lines
Published in Nutrition and Cancer, 2022
Jiayi Xiong, Juanjuan Sheng, Yan Wei, Zhimin Sun, Xia Xiao, Lanmei Zhang
Phytochemicals show preventive and therapeutic effects against cervical cancer cells (14). Therefore, treatment with natural phytochemicals was considered a novel approach to sensitize paclitaxel toxicity without significant adverse effects. Sesamum indicum, a medicinal herb, possesses potent phytochemicals which exhibit important anticancer properties (15). Sesamol is a naturally occurring lignan present in the seeds of Sesamum indicum that exhibits anticancer properties (16). The pharmacological perspectives of sesamol were demonstrated by several researchers (16–19). The methylenedioxy ring-opening skeleton was reported for its potent anticancer property (20). Further, sesamol exhibited selective toxicity in human melanoma cells (21). Recent studies illustrated that sesamol served as a chemosensitiser and up-regulated death receptors in the solid Ehrlich carcinoma model (22). Therefore, in the present study, the authors investigated the chemosensitising potential of sesamol in HeLa cervical cancer cells.
Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis
Published in Immunopharmacology and Immunotoxicology, 2018
Ali-Mohammad Rousta, Seyed-Mohamad-Sadegh Mirahmadi, Alireza Shahmohammadi, Davood Nourabadi, Mohammad-Reza Khajevand-Khazaei, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Sesamin is the major lignan in sesame (Sesamum indicum) seeds and one of the two significant sources of lignans in human diet and an important nutritional supplement with multiple beneficial effects [11]. Sesamin has shown anti-oxidative [12–15] and anti-inflammatory [16,17] effects, is capable to prevent impairment of mitochondrial function in high-fat-diet-induced model of diabetes [18] and protects against alcohol-induced liver injury in rodents [19]. In addition, sesamin could protect against injury due to renal ischemia reperfusion in mice via suppression of inflammatory responses [20], is capable to alleviate high-fat-diet-induced hyperlipidemia and kidney injury through amelioration of oxidative stress [21], and to attenuate doxorubicin-induced hepatorenal toxicity via inhibition of oxidative stress [22]. Of related significance, sesamin has exhibited protective effect against fluoride-induced oxidative stress and apoptosis in kidney tissue [23]. On this foundation, this research study was designed to explore whether sesamin could attenuate renal oxidative stress, inflammation, and apoptosis in LPS-induced model of AKI in mice.
Sesamin and sesamol attenuate H2O2-induced oxidative stress on human neuronal cells via the SIRT1-SIRT3-FOXO3a signaling pathway
Published in Nutritional Neuroscience, 2021
Waralee Ruankham, Wilasinee Suwanjang, Prapimpun Wongchitrat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin
Phytochemical constituents with antioxidant activities have drawn the most attention, aiming to use them as drugs or supplements for preventing or delaying the progression of NDs.8 Sesamin and sesamol (Figure 1(A and B)) are natural antioxidant compounds extracted from sesame (Sesamum indicum Linn). This plant species is a tropical oil crop found around the world, especially in India, China, Thailand, and Africa, that has a long history of traditional use as a health supplement. The previous studies revealed the potential roles of sesamin and sesamol as antioxidant and antimicrobial of foodborne pathogens: Bacillus cereus, Staphylococcus aureus, and Pseudomonas aeruginosa as well as anti-tuberculosis.9,10 Sesamin exhibited ER stress-mediated apoptosis through JNK pathway in cervical cancer cells, and ultimately promoted mitochondrial apoptotic and autophagic pathways.11 It has been reported that sesamol-treated skin tumor mice and hepatocellular carcinoma cells altered the expression of BCL-2 and BAX proteins.12,13 Moreover, both compounds also exerted anxiolytic and anti-inflammatory effects in RAW264.7 macrophages which can be used for treatment of atherosclerosis and lung injury.14,15 However, the effects of sesamin and sesamol on preventing neurodegeneration remain unclear. Thus, we aimed to explore the neuroprotective effects of sesamin and sesamol on H2O2-induced human neuroblastoma SH-SY5Y cell death, and possible SIRT1-SIRT3-FOXO3a neuroprotective regulatory mechanisms which may lead to antioxidant responses and neuronal survival.