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Management of stones and strictures and interventional sialography
Published in John Dudley Langdon, Mohan Francis Patel, Robert Andrew Ord, Peter Brennan, Operative Oral and Maxillofacial Surgery, 2017
Michael P Escudier, Jacqui E Brown
Later studies investigated the use of laser lithotripsy and several systems have been evaluated in vitro and in vivo. Unfortunately, the Nd-YAG (1064 nm; LASAG-AG, Belp, Switzerland) and Alexandrite (755 nm; Dornier Medizintechnik, Germany) lasers were unsuitable because of inadequate fragmentation. In the case of the Exicmer laser (308 nm; Technolas Laser Technologie, Germany), stone- free rates of up to 91.6% were reported, but were associated with a high rate of ductal perforation and its use in humans is inadvisable. The Rhodamine-6G-Dye-laser (595 nm; Lithoghost, Telemit-Company, Munchen, Germany), however, proved successful. This had the added advantage of using a novel spectroscopic feedback technique which analysed the reflected laser light to distinguish between calculi and soft tissue, so minimizing damage to the duct. Its use was associated with complete removal of stones in 46% of cases after between one and three treatment sessions.
Clarity of Abstract and Conclusion
Published in Kitsakorn Locharoenrat, Research Methodologies for Beginners, 2017
In the present work, we have investigated potential enhancement of the fluorescence emission of the standard dyes Rhodamine 6G and Coumarin153 doped with the metallic nanostructures of three different shapes. These are gold–palladium core–shell nanorods, gold nanobipyramids, and single–crystalline porous palladium nanocrystals. We have obtained the highest (more than threefold) fluorescence enhancement on the system of Rhodamine 6G mixed with the gold–palladium core–shell nanorods. On the contrary, the smallest fluorescence changes have been observed for Coumarin153 that involves the porous single-crystalline palladium nanocrystals.
Design, characterization and antimalarial efficacy of PEGylated galactosylated nano lipid carriers of primaquine phosphate
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Uday Krishna Baruah, Kuppusamy Gowthamarajan, Vanka Ravisankar, Veera Venkata Satyanarayana Reddy Karri, Praveen Kumar Simhadri, Vineeta Singh, Phanithi Prakash Babu
In vivo fluorescence imaging was performed with the help of an In vivo MS FX PRO, Bruker imaging system (Coventry, UK). Rhodamine 6G solution and Rhodamine 6G loaded NLCs were used as the sample for the I.P administration in the (healthy mice of 4–5 weeks old) C57BL/6 mice (n = 3) to find out the fluorescent distribution of the samples in the whole body. Rhodamine 6G has an excitation and emission wavelength of 526 and 555 nm. The fluorescent imaging of the respective animal groups was recorded at a time interval of 2 and 8 h after the post I.P injection to the animals. For in vivo imaging, the mice were anaesthetized by inhalation of 5% isoflurane and for ex vivo imaging the animals were sacrificed by cervical dislocation under narcosis and then various organs were dissected out for fluorescence imaging.
The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans
Published in Pharmaceutical Biology, 2016
Jing Shao, MengXiang Zhang, TianMing Wang, Yue Li, ChangZhong Wang
A volume of Ca z2003 culture (2 mL) was adjusted to 1 × 108 cells/mL in RPMI 1640. The suspension was then mixed separately with the same volumes of FLC, KAE, and FLC + KAE to the final concentrations of 32 μg/mL, 128 μg/mL, and 32 + 128 μg/mL at 37 °C for 5 h of incubation. After centrifugation at 2000g, the supernatant was discarded, mixed with 2 mL sterile PBS for 2 h of incubation at 37 °C with an agitation of 200 rpm. Subsequently, rhodamine-6G was added to a final concentration of 10 μmol/L for 2 h of incubation at 37 °C. The solution was centrifuged at 3000g, and the supernatant was discarded. The pellets were washed three times by sterile PBS. As efflux of rhodamine-6G from Candida cells required the presence of glucose, glucose dissolved in PBS was coincubated with the pellets to the final concentration of 2 mmol/L at 37 °C 200 rpm for 1 h. The suspension was centrifuged at 3000 g. An aliquot of supernatant (100 μL) was removed and detected at an excitation wavelength of 525 nm and an emission wavelength of 550 nm with an inverted fluorescence microscope IX71 (Olympus, Tokyo, Japan) (Peralta et al. 2012).
Development and characterization of chitosan nanoparticles containing an indanonic tricyclic spiroisoxazoline derivative using ion-gelation method: an in vitro study
Published in Drug Development and Industrial Pharmacy, 2020
Ahmad Abolhasani, Fatemeh Heidari, Hoda Abolhasani
Many efforts have been devoted to finding out the temperature sensitivity of the drug release from loaded nanoparticles. For example, the specially synthesized cisplatin loaded nanoparticles show a temperature-dependent increase of cisplatin release, at neutral pH (as in blood and normal tissue). Over the time scale, it monitored that cisplatin always showed the highest release percentage at 42 °C, compared to 37 and 32 °C [54]. The effect of temperature on the swelling ratio and drug release through PHEMA nanoparticles in the range of 12–37 °C has been investigated by Chouhan. The results are indicated that swelling increased with temperature up to 25 °C but decreased above this temperature. However, the cumulative release was highest at 37 °C [55]. Besides, a mathematical analysis that considers the temperature effects of the controlled drug release process from biodegradable poly-D,L-lactide-co-glycolide (PLGA) nanoparticles was described. The release of Rhodamine 6G from the nanoparticles was investigated at 37, 47, and 57 °C, ending a multiphasic release behavior. An increase in the entire drug release process was observed with the increase of temperature [56]. The effects of different temperatures of the medium on the Brilliant Blue F release also behavior from porous hollow silica nanoparticles were studied by Li et al. at three different temperatures of 293, 300, and 310 K, respectively. the Brilliant Blue F release rate increased with the rise of the temperature [57]. In another study, the rate of dextran release from the poly-N-isopropyl acrylamide-co-allylamine network was temperature-dependant, being much faster at room temperature than that at human body temperature [58].