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Inhibiting the Absorption of Dietary Carbohydrates and Fats with Natural Products
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Aqueous liquid extract from roots of Rheum ribes L. (10g/100 mL) a concentration of 50 mg/mL halved glucose liberation from starch by α-amylase by 50%.33 At a dose of 125 mg/kg, this extract decreased peak glycaemia at 45 minutes in oral starch tolerance test similar to 3 mg/kg of acarbose in Sprague–Dawley rats at 5 mM.33 The petioles of members of the genus Rheum are particularly rich in fibers, and it must be recalled that dietary fiber adsorb bile acids and cholesteryl ester and promote bile formation and cholesterol fecal excression. Such fibers are particularly present in the leaf stalks of Rheum officinale Baill., which given at a dose of 27 g/day to hypercholesterolaemic volunteers for 4 weeks following habitual diets had no effect on the body mass index but induced a mild decrease of total cholesterol and triglycerides from 2.1 to 1.8 mmol/L.34
Bioactive Compounds of Rheum ribes L. and its Anticancerogenic Effect via Induction of Apoptosis and miR-200 Family Expression in Human Colorectal Cancer Cells
Published in Nutrition and Cancer, 2021
İlknur Çınar Ayan, Sümeyra Çetinkaya, Hatice Gül Dursun, İpek Süntar
Many plant species that grow in Turkey are used among the population to reduce/eliminate the symptoms of various diseases. Rheum ribes L. is a medicinal plant belongs to Polygonaceae family. It shows a wide distribution in the Eastern parts of Turkey. It is used for the treatment of various diseases such as ulcers, diabetes, hypertension, and also consumed as digestive and anti-helminthic by the local people (6). Studies that investigated the therapeutic efficacy of the R. ribes, are mainly related to its antimicrobial and antiradical properties (7–9). In a few studies evaluating the anti-carcinogenic properties of the plant, only the cytotoxic and apoptotic effects of the plant were investigated on various types of cancer (10–13). To the best of our knowledge, there have been no detailed study investigates the molecular mechanisms underlying the possible anticancer properties of R. ribes In Vitro.
Effect of isgin (Rheum ribes L.) on biochemical parameters, antioxidant activity and DNA damage in rats with obesity induced with high-calorie diet
Published in Archives of Physiology and Biochemistry, 2023
Bedia Bati, Ismail Celik, Abdullah Turan, Nese Eray, Elif Ebru Alkan, Ali Kemal Zirek
Plant-derived compounds are very important due to their various biological effects such as anti-obesity, anti-cancer, anti-diabetes mellitus, anti-hypertension, anti-inflammatory, antioxidant, antimicrobial and anti-Alzheimer (Gulcin 2006, Ak and Gulcin 2008, Gulcin 2010, Sharifi-Rad et al. 2018, Salehi et al. 2019, Islam et al. 2020). Rheum ribes has been commonly used as a food source, medical and supplementary medication in Turkey and around the world since ancient times. Rheum ribes L. is a perennial plant, a species of wild rhubarb, which is a member of the Polygonacea family cultivated in Lebanon, Iran, Iraq and eastern regions of Turkey. Additionally, in northern Iraq and in Van and surrounding counties in Turkey, the shoots and roots of this plant are commonly used among the public in the spring months (Ozturk et al. 2007). The Polygonaceae family comprises 8 genera and 70 species, with Rheum ribes L. the only genera of Rheum grown in Turkey (Cullen 1966). Rheum ribes roots are used in the treatment of hypertension, diabetes, obesity and renal diseases (Abu-Irmaileh and Afifi 2003, Uyar 2006, Keser et al. 2019). Additionally, some rhubarb species were identified to have hypoglycaemic activity (Konak and Aktar 2009). Plant boiled roots are used in treatment of anaemia, anorexia, mental exhaustion, gangrene and hypertension in alternative medicine (Abu-Irmaileh and Afifi 2003). Rheum ribes is used as one of the most important pharmaceutical raw materials in Asia and the Middle East as the structure includes anthracene derivatives. Rhubarb contains more than 250 bioactive chemical materials including anthropinones (emodin, crysophanol, physcion, aloe emodin and emodin glycosides), anthrones, flavonoids, alkyl glucosides and pylone stilbene (Oktay et al. 2007, Singh et al. 2016). A study revealed that Rheum was a functional food due to high phenolic material content, strong bonding to free radicals and antioxidant characteristics (Meral 2017).