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Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Synonym: Rehmannia chinensis Libosch. ex Fisch. & C.A. Mey.Subclass Lamiidae, Superorder Lamianae, Order Lamiales, Family ScrophulariaceaeCommon name: di huang (Chinese)Medicinal use: tonic (China)
Examples of TCM formulas used in Chinese medicine
Published in Raymond Cooper, Chun-Tao Che, Daniel Kam-Wah Mok, Charmaine Wing-Yee Tsang, Chinese and Botanical Medicines, 2017
Raymond Cooper, Chun-Tao Che, Daniel Kam-Wah Mok, Charmaine Wing-Yee Tsang
The Liuwei-Dihuang preparation contains a six-ingredient decoction (or pill) with Rehmannia (Liuwei Dihuang Tang(wan)). It is mostly well known to restore yin deficiency of the kidney and is used as a tonic for general weakness.
Antipsoriatic Medicinal Plants
Published in José L. Martinez, Amner Muñoz-Acevedo, Mahendra Rai, Ethnobotany, 2019
José Luis Ríos, Guillermo R. Schinella, Isabel Andújar
Deng et al. (2013a,b, 2017) reviewed and evaluated the efficacy and safety of topically used plant extract preparations by psoriasis patients. A total of twelve studies were investigated, including three with Aloe vera, five with Berberis aquifolium, two with indigo naturalis, one with kukui nut oil (Aleurites moluccanus) and one with Camptotheca acuminata nut. Some of these plant extracts have partial effects on psoriasis symptoms, such as inflammation and cell proliferation. However, the clinical trials analyzed did not provide clear evidences that would support their topical use on psoriatic plaques, probably due to the small size of most studies and methodological weaknesses (Deng et al. 2013a). Similar results were obtained by the same authors after reviewing the evidence for the efficacy and safety of herbal medicines used topically in conjunction with antipsoriatic pharmacotherapy (Deng et al. 2013b). In a third study, they analyzed the efficacy and safety of oral forms of phytotherapy in psoriasis management and discussed the pharmacological actions of the plants used in clinical trials. Their results demonstrated that the most commonly used plants were Oldenlandia diffusa, Rehmannia glutinosa and Salvia miltiorrhiza, which also have anti-inflammatory, anti-proliferative and anti-oxidative properties, which are of relevance to psoriasis management (Deng et al. 2014). In a recent study, these same authors analyzed a preparation formed by different medicinal plants (PSORI-CM01, a modified form of Yinxieling) comparing the results with the original Chinese herbal formula for psoriasis Yinxieling (in tablet) and placebo, and demonstrated in a randomized, double-blinded and multicentral clinical trial, that this formula improved PASI scores and relapse rates in psoriasis vulgaris (Deng et al. 2017). The formula was then modified (PSORI-CM02) eliminating two herbs (liquorice and lithospermum), keeping the remaining five from PSORI-CM01 (Curcumae rhizoma, Radix paeoniae rubra, Rhizoma smilacis glabrae, Mume fructus, and Sarcandrae herba). PSORI-CM02 was tested as a possible suppressor of alloimmunity; results show that it inhibited murine skin allograft rejection and reduced graft-infiltration of CD3+ T cells, which led the authors to hypothetize a potential interest of this new formula against autoimmune psoriasis (Lu et al. 2018).
The protective effect of decoction of Rehmanniae via PI3K/Akt/mTOR pathway in MPP+-induced Parkinson's disease model cells
Published in Journal of Receptors and Signal Transduction, 2021
Rehmannia glutinosa, a member of the Scrophulariaceae family, has long been used as a traditional Chinese medicine. Previous studies suggest that Rehmannia glutinosa possesses various pharmacological activities, including anti-inflammatory [18], anti-tumor [19], anti-oxidative [20], and antidepressant [21] functions. Rehmanniae is the root of Rehmannia glutinosa, and the decoction of Rehmanniae (DOR), which serves as a classical prescription, has long been used to treat neurological disorders. The combination of levodopa and Zishenpingchan granules (consisting of Radix Rehmanniae preparata, etc.) can markedly improve dyskinesia and delay the progression of Parkinson's disease [22]. However, the protective effect of Rehmanniae decoction on SH-SY5Y cells with acute injury induced by MPP+ has not been concretely studied yet.
Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy
Published in Renal Failure, 2018
Lu Gan, Xiaozhao Li, Mengyuan Zhu, Chen Chen, Huimin Luo, Qiaoling Zhou
Rehmannia glutinosa is a traditional medicine, which is widely used in Chinese, Russian and Japanese medicine for its anti-infection, anti-inflammation and immune-regulation abilities. Acteoside (ACT), the main component of Rehmannia glutinosa, has a wide range of effects, including regulation of immune and inflammatory responses [3]. Previous researches demonstrated that acteoside could improve urinary protein excretion and decrease the incidence of mesangial expansion [4,5]. This makes acteoside a possible therapy of IgAN.
Efficacy and safety of Run Zao Zhi Yang capsule on chronic eczema: a multiple-center, randomized, double-blind, placebo-controlled clinical study
Published in Journal of Dermatological Treatment, 2019
Dan Huang, Kun Chen, Fu-Ren Zhang, Sen Yang, Qing Guo, Jin-Hua Xu, Hui Li, Guo-Zhen Tan, Bao-Qi Yang, Qian-Jin Lu, Jie Zheng, Lin-Feng Li, Heng Gu
In TCM theories, eczema is considered as ‘Itchy wind’ and ‘hot heart’, the disease is ‘blood deficiency’ and ‘dryness’. Runzao Zhiyang Capsule recipe is derived from the folk prescription of Guizhou Miao Ethnicity and purified by modern pharmaceutical technology. The main components of the capsule are rehmanniae and flavescens, followed by radix polygonum multiflorum, Laportea bulbifera herba, and mulberry leaf act as auxiliary medicine. Rehmannia improves IL-2 function, inhibits IgE production, and effectively controls release of histamine from mast cell, further playing antiinflammatory and antibacterial roles (19,20). Sophora flavescens contains matrine which has analgesic effects and immune regulating function, reduces the release of inflammatory mediators, and oxymatrine reduces histamine by the prevention of mast cells from degranulation and inhibits phagocytosis of macrophage (21,22). Polygonum multiflorum and Radix Polygoni Multiflori promote adrenocortical function, block mast cell degranulation, thereby inhibiting histamine release, and improve itching (23,24). Laportea bulbifera herba has anti-inflammatory, analgesic, and immunosuppressive effects, mulberry leaves have antibacterial, remove oxygen free radicals, and reduce depression (25,26). The combination of the aforementioned drugs has significant effects in relieving itching, improving the internal environment of the body, and regulating immunity. From the aspect of dialectical theory of TCM, RZZYC can shorten the course of disease and reduce the degree of itching to increase the itch threshold by nourishing yin, removing wind and itching, and treating both from inside and outside body. So, it is the optimal choice of skin diseases caused by blood deficiency, wind dryness, and blood dryness, such like chronic eczema and pruritus. In recent years, there have been several clinical trials of RZZYC combined with antihistamines for chronic eczema with satisfied outcomes (11,27,28). In order to scientifically evaluate the effectiveness and safety of RZZYC on chronic eczema, we designed this randomized, double-blind, placebo-control study in nine centers over China. After 4 weeks treatment, the proportion of subjects with EASI 95 and 60 reached 69.2% in the experimental group, and the EASI gradually decreased as time of treatment increased (Figure 2). The decrease of secondary indicators including VAS scores and IGA scores was consistent with the decreasing trend of EASI, which suggested that RZZYCs had a higher effective rate on the treatment of mild-to-moderate chronic eczema.