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Part 5: Hyperactivity, Attention Deficit Disorders and Homeopathy
Published in Aruna Bakhru, Nutrition and Integrative Medicine, 2018
Some treatments can be very simple and yet the results are striking, such as giving 3 granules 2 times a day of THUYA 9CH for warts, APIS 4CH for allergic reactions, and IGNATIA 9CH for anxiety. In pediatrics, mental behaviors can be improved drastically. AMBRA GRISEA will help a timid child, and CINA 15 CH an awkward child. When physical symptoms are related to mental symptoms, and/or to concomitants and general modalities, homeopathy works at its best. For example, think about a patient suffering from otitis. He is aggravated by all kinds of heat and improved by cold applications, his weeping mood can change to a smile when comforted, he is never thirsty and runs a high fever. This patient will be treated successfully with PULSATILLA.
Whole Medical Systems
Published in Hilary McClafferty, Integrative Pediatrics, 2017
A randomized double blind placebo-controlled trial of 75 children received an individualized homeopathic medicine versus placebo orally three times a day for 5 days or until symptoms resolved—whichever came first. Results showed fewer treatment failures in the homeopathic group, although results were not statistically significant. Rate of symptom improvement was significantly faster in the treatment group (p < 0.05). The most commonly prescribed homeopathic remedies included Pulsatilla nigricans, Chamomilla, Sulphur, and Calcarea carbonica (Jacobs, Springer, and Crothers 2001).
Homeopathy: principles, practice and controversies
Published in Geraldine Lee-Treweek, Tom Heller, Hilary MacQueen, Julie Stone, Sue Spurr, Complementary and Alternative Medicine: Structures and Safeguards, 2020
Phil Nicholls, Geraldine Lee-Treweek, Tom Heller
Hahnemann spent the years that followed his experiment elaborating and refining the homeopathic system. His experience with Cinchona persuaded him that the key to identifying the therapeutic domain of drugs was to ‘prove’ potential remedies on healthy people. Hahnemann used himself, his friends and family to ‘prove’ his new remedies. Detailed records were made of the physical and mental symptoms experienced by ‘provers’ after the drug was administered, and a ‘picture’ of the drug was established from the resulting data. The principle of treatment by similarity then indicated the cases in which the drug should be used. When a detailed picture of the signs and symptoms of a sick patient matched those produced by a drug on healthy people, the correct remedy for the patient had been established. Ill people would be treated with a drug that could give them the same symptoms if they were well. Hahnemann developed his idea that it was clearly of utmost importance to collect detailed information about the sick person to get the remedy absolutely right. By the time he died, in 1843, he had supervised the proving of some 99 medicines in this way. Now thousands of remedies have been ‘proved’ and are used for homeopathic treatment. For example, a homeopath would treat a patient with a cold whose primary symptoms are lacrimation, stinging and irritation of the eyes, and thin, clear nasal discharge with a potency prepared from onion extracts (Allium cepa) because these symptoms mimic those produced by onions. However, another patient with a cold might have thick, yellow nasal discharge, have lost all thirst, and want cool, fresh air. That person would be treated with a potency of the purple cone flower (Pulsatilla) because these symptoms are more characteristic of those produced by this plant.(Jonas et al., 2003, p. 393)
Protective effect of Pulsatilla saponin A on acute myocardial infarction via miR-24-3p/p16
Published in Toxicology Mechanisms and Methods, 2022
Feng Dong, Yanhua Pu, Yanfei Lv, Xiujuan Liu, Yimin Cao
Traditional Chinese medicine (TCM) has been receiving considerable attention because of its curative effect with low-side effects (Zhao et al. 2016) to treat myocardial ischemia (Li, Xing et al. 2016). For example, Polydatin has been shown a protective effect against CM injury associated with AMI by activating Sirt3 (Zhang et al. 2017). Pulsatilla Chinensis Regel is an herb known in TCM for ‘blood-cooling’ and detoxification and, thus, is commonly used in TCM to treat infectious diseases. In recent years, PsA has been reported to exhibit anti-tumor activities. It induces apoptosis and differentiation of myeloma cells (Ye et al. 2021). It can also trigger apoptosis and inhibit tumor growth of human colon cancer cells with or without 5-FU (Xu et al. 2017). Our research found that PsA pretreatment ameliorated hypoxia-induced H9c2 cell toxicity. The viability of H9c2 cells pretreated with PsA before being sent to hypoxic conditions could be enhanced in a dose-dependent manner (0–10 μg/ml). Then, the apoptosis rate was also suppressed which revealed that PsA relieved hypoxia-triggered cell toxicity in H9c2 cells.
Pulsatilla saponin E suppresses viability, migration, invasion and promotes apoptosis of NSCLC cells through negatively regulating Akt/FASN pathway via inhibition of flotillin-2 in lipid raft
Published in Journal of Receptors and Signal Transduction, 2022
Minghua Zhu, Wei Shi, Ke Chen, Huiqun Hu, Xiangqing Ye, Yinfang Jiang
It has been found that up-regulated FASN increase ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma, which affects LRs in the regulation of functional structure of cell membrane [18]. In this study, we also found that the inhibitory effects of pulsatilla saponin E on expressions of flotillin-1, flotillin-2, Akt, and FASN were reversed by flotillin-2 transfection. The data suggested that pulsatilla saponin E suppressed Akt/FASN pathway through inhibiting flotillin-2. Collectively, this study proved that pulsatilla saponin E suppressed migration and invasion of NSCLC through negatively regulating Akt/FSAN pathway via the inhibition of LRs function. Moreover, the effects and potential mechanism of pulsatilla saponin E on migration and invasion of NSCLC suggested that it can be used as a potential therapeutic drug for treating NSCLC patients with metastasis. However, the exact effects of pulsatilla saponin E should be further determined.
α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis
Published in Pharmaceutical Biology, 2021
Cong Fang, Yahui Liu, Lanying Chen, Yingying Luo, Yaru Cui, Ni Zhang, Peng Liu, Mengjing Zhou, Yongyan Xie
Pulsatilla chinensis (Bunge) Regel (Ranunculaceae), which is used for its cooling and detoxifying abilities, has been reported to have many pharmacological characteristics such as being antimalarial and antibacterial (Cheng et al. 2008) and an anticancer agent (Liu et al. 2013). In our previous study, we demonstrated that three monomers of Pulsatilla chinensis, PSA, R13, and PSD, can considerably inhibit the proliferation of tumour cell lines (Guan et al. 2020). α-Hederin (Figure 1(a)) is a monosaccharide chain pentacyclic triterpenoid saponin and is one of the effective components of the traditional Chinese medicine Pulsatilla chinensis. Studies have found that α-hederin plays many pharmacological roles, including antitumor, antifungal, insecticidal, antispasmodic, analgesic, and hepatic protection (Shi and Liu 1996; Ridoux et al. 2001; Li et al. 2003; Rooney and Ryan 2005; Sieben et al. 2009).