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Drug profiles: generic names A-Z
Published in Jerome Z. Litt, Neil H. Shear, Litt's Drug Eruption & Reaction Manual, 2017
Clinically important, potentially hazardous interactions with: abacavir, abiraterone, afatinib, amiodarone, amprenavir, anisindione, antacids, anticoagulants, apixaban, apremilast, aprepitant, artemether/lumefantrine, atazanavir, atorvastatin, atovaquone, atovaquone/proguanil, beclomethasone, bedaquiline, betamethasone, bisoprolol, boceprevir, bosentan, brentuximab vedotin, buprenorphine, cabazitaxel, cabozantinib, canagliflozin, caspofungin, clobazam, clozapine, cobimetinib, corticosteroids, cortisone, crizotinib, cyclosporine, cyproterone, dabigatran, daclatasvir, dapsone, darunavir, dasatinib, deferasirox, delavirdine, dexamethasone, diclofenac, dicumarol, digoxin, doxycycline, dronedarone, efavirenz, emtricitabine/rilpivirine/tenofovir alafenamide, enzalutamide, estradiol, eszopiclone, etoricoxib, etravirine, everolimus, fesoterodine, flibanserin, fludrocortisone, flunisolide, fosamprenavir, gadoxetate, gefitinib, gestrinone, halothane, hydrocortisone, imatinib, indinavir, isoniazid, itraconazole, ixabepilone, ketoconazole, lapatinib, ledipasvir & sofosbuvir, leflunomide, lesinurad, levodopa, levonorgestrel, linagliptin, linezolid, lopinavir, lorcainide, losartan, lurasidone, macitentan, maraviroc, methylprednisolone, midazolam, mifepristone, nelfinavir, nevirapine, nifedipine, nilotinib, ombitasvir/paritaprevir/ritonavir, ondansetron, oral contraceptives, osimertinib, ospemifene, oxtriphylline, paclitaxel, pazopanib, perampanel, phenylbutazone, pioglitazone, pitavastatin, ponatinib, praziquantel, prednisolone, prednisone, propranolol, propyphenazone, protease inhibitors, pyrazinamide, quinine, raltegravir, ramelteon, ranolazine, regorafenib, rilpivirine, riociguat, ritonavir, rivaroxaban, roflumilast, romidepsin, rosiglitazone, saquinavir, simeprevir, simvastatin, sofosbuvir, solifenacin, sorafenib, sunitinib, tacrolimus, tadalafil, tasimelteon, telaprevir, telithromycin, temsirolimus, terbinafine, thalidomide, ticagrelor, tipranavir, tofacitinib, tolvaptan, trabectedin, treprostinil, triamcinolone, triazolam, trimethoprim, troleandomycin, ulipristal, vandetanib, vemurafenib, voriconazole, vortioxetine, warfarin, zaleplon, zidovudine, zolpidem
Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief
Published in Temperature, 2023
Luigi F. Iannone, Romina Nassini, Riccardo Patacchini, Pierangelo Geppetti, Francesco De Logu
Some analgesics and herbal medicines/natural products widely used for the acute treatment of headache attacks seem to act via TRPA1. The highly reactive metabolite of acetaminophen N-Acetyl-parabenzoquinone-imine (NAPQI), responsible for hepato- and nephron-toxic effects of the drug, target TRPA1, promoting a mild neurogenic inflammatory response [112]. CYP450 monooxygenase activity may produce NAPQI and parabenzoquinone (p-BQ) in the spinal cord, thus locally activating TRPA1 and causing a prolonged desensitization of voltage-gated calcium and sodium currents in primary sensory neurons. The effect of spinal and systemic administration of acetaminophen was absent in TRPA1 deleted mice, suggesting that NAPQI and p-BQ produce a TRPA1-mediated spinal antinociception in [113]. Pyrazolone derivatives (including dipyrone, antipyrine, aminopyrine, and propyphenazone) have been used for decades for the acute relief of migraine attacks, although the specific mechanism of their antimigraine and analgesic action remains unknown [114]. Dipyrone and propyphenazone have been found to selectively antagonize TRPA1 in vitro and in vivo and to attenuate nociception and allodynia in animal models of neuropathic and inflammatory pain, independently from prostaglandin production and via a TRPA1-mediated mechanism [115].
A review of published cases of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with the use of acetaminophen
Published in Cutaneous and Ocular Toxicology, 2021
Miloš N. Milosavljević, Ana V. Pejčić, Jovana Z. Milosavljević
Acetaminophen, also known as paracetamol, is a widely used analgesic and antipyretic drug typically recommended for management of mild-to-moderate pain and fever associated with various conditions such as common cold, viral and bacterial infections, headache, toothache, trauma or menstrual cramps [1,2]. In 1961, the Food and Drug Administration (FDA) classified acetaminophen as an over-the-counter (OTC) drug because of its good tolerability, rare adverse effects, and low potential for drug-drug interactions [3,4]. It can be administered orally, rectally or intravenously [4], and is available in a large number of prescription and OTC products, alone or in combination with other active ingredients (e.g. codeine phosphate, ascorbic acid, diphenhydramine hydrochloride, ibuprofen, propyphenazone, et cetera) [3]. It is considered to be a relatively safe drug at therapeutic doses, and is also recommended in case of intolerance of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) [5]. However, in case of overdose it can cause acute liver injury and death from acute liver failure [2].
Diagnosing and managing patients with drug hypersensitivity
Published in Expert Review of Clinical Immunology, 2018
Javier Fernandez, Inmaculada Doña
Regarding NSAIDs, immunoassays (mainly ELISA) based on experimental or commercially available prototypes may be applicable [40,41] with a sensitivity of 58% for propyphenazone [40]. With other NSAIDs such as acetylsalicylic acid (aspirin), sIgE has only been detected for a small number of patients [66]. A panel of monoclonal antibodies to diclofenac have been developed; however, sIgE antibodies in humans were not detected [67,68].