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Migraine
Published in Charles Theisler, Adjuvant Medical Care, 2023
Butterbur(Petasites hybridus) root extract contains petasin and isopetasin, which have vasodilation properties and reduce inflammation. A dosage of 50–75 mg/day in two divided doses in children 6–9 years and 50–75 mg twice daily for four months in adults for four months has been shown to reduce migraines.30,31
Ethnobotany of the Silk Road – Georgia, the Cradle of Wine
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Rainer W. Bussmann, Narel Y. Paniagua Zambrana, Shalva Sikharulidze, Zaal Kikvidze, David Kikodze, David Tchelidze, Ketevan Batsatsashvili
Even more surprising is the wide variety of young leaves of wild vegetables, which are consumed as food in the Spring (Figure 11.9), e.g., Atriplex hortensis L., Berberis vulgaris L. (fruits), Campanula lactiflora M. Bieb., Cirsium arvense (L.) Scop., Dryopteris filx-mas (L.) Schott., Fritillaria collina Adams, Lamium album L., Lathyrus roseus Steven, Lilium ledbourii (Baker) Boiss., Malva neglecta Wall and Malva sylvestris L., Mattheuccia struthiopteris (L.) Todd., Myosotis arvensis (L.) Hill, Oberna lacera (Steven) Ikonn. and O. wallichiana (Klotzsch) Ikonn., Petasites albus (L.) Gaertn and Petasites hybridus (L.) G. Gaertn., Polygonatum glaberrimum C. Koch. and Polygonatum orientale Desf., Polygonum alpinum All.; Polygonum aviculare L.; Polygonum carneum C. Koch; Polygonum. hydropiper L., Portulacca oleracea L., Primula woronowii Losinsk., Rubia tinctoria L., Rumex acetosa L.; Rumex acetosella L.; Rumex. confertus Willd.; Rumex conglomeratus Murray; Rumex crispus L.; Rumex tuberosus L.; Smilax excelsa L., Stellaria media (L.) Vill., Viola arvensis L., and finally, Viola odorata L.
Migraine: Management and Treatment with Herbal Drugs
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Arulmozhi D. Kandasamy, Yogesh Anant Kulkarni, Addepalli Veeranjaneyulu, Ram S. Gaud
Phytomedicine has offered alternative source of therapy for migraine sufferers, and provided some additional information about the pathogenesis of migraine.13,14 Feverfew (Tanacetum parthenium) and butter bur (Petasites hybridus) are some of the plants that have been used for centuries for relief of migraine.15,16 Many plants like “Sapindus trifoliatus” have been studied scientifically for their effects in migraine.17–19
Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief
Published in Temperature, 2023
Luigi F. Iannone, Romina Nassini, Riccardo Patacchini, Pierangelo Geppetti, Francesco De Logu
Regarding herbal products, Tanacetum parthenium (feverfew) and Petasites hybridus Gaertn (butterbur) have been used for centuries to treat migraine and other pain conditions. Some preparations containing parthenolide (a feverfew constituent) and butterbur (in particular, its components, petasin and isopetasin) are or have been used for migraine prophylaxis [116]. In rodents, parthenolide and isopetasin behave as TRPA1 partial agonists [61,117] with an initial activation followed by prolonged concentration- and dose-dependent specific TRPA1 desensitization and nonspecific desensitization of peptidergic nociceptors, which express the channel [61]. In this manner, nociceptor nerve fibers became unresponsive to any stimulus, and unable to release CGRP from their terminals, including those present in the trigeminovascular system. Finally, a compound contained in plants largely used in traditional medicine, ligustilide, has been identified as a TRPA1 partial agonist, with a certain degree of inhibitory activity on mustard oil activated currents in the dural [118].
Synergistic immunosuppressive effect of hispidulin and nepetin mixtures on human T lymphocytes
Published in Immunopharmacology and Immunotoxicology, 2022
Premrutai Thitilertdecha, Varangkana Tantithavorn, Poonsin Poungpairoj, Nattawat Onlamoon
As these evidences for anti-inflammation of hispidulin and nepetin were conducted in animal models and using isolated compounds from plants, the biological activity cannot be genuinely explained for the compounds’ functions themselves and for mechanisms of actions in human. In our previous study, results showed that individual hispidulin and nepetin possessed immunosuppression in early T-cell activation using human T lymphocytes [22]. In addition, nepetin presented selective inhibition at low concentration. Even so, a final therapeutic outcome when using a combination of the two compounds remains ambiguous whether the effect will be synergism or antagonism. It is warranted for further study as a scientific support for the use of the Thai medicinal plant C. petasites and a feasible alternative approach to achieve higher efficacy for immunosuppression instead of using a single active component. Therefore, this study aimed to evaluate the inhibitory effects on anti-CD3/28 stimulated human T lymphocytes when treating with the combination of hispidulin and nepetin at different His:Nep concentration ratios following a naturally-occurring dose (3:1) as well as optimized doses (1:1 and 1:3). The cytotoxicity tests were also performed to ensure that their immunosuppressive properties did not cause from cell death and to assure the safety of uses.
AMPK/Nrf2 signaling is involved in the anti-neuroinflammatory action of Petatewalide B from Petasites japonicus against lipopolysaccharides in microglia
Published in Immunopharmacology and Immunotoxicology, 2018
Sun Young Park, Min Hyun Choi, Mei Li, Ke Li, Geuntae Park, Young-Whan Choi
Abnormal microglia activation is triggered by various pathogenic mechanisms including neuroinflammation and altered neuronal function and damage. Since abnormal microglia activation is the histopathological hallmark of neurodegenerative diseases, suppressing such activation has been suggested as a promising therapeutic target27,28. Natural compounds are gaining prominence as valuable candidate substrates for the development of medications. A previous study found that Petatewalide B is the main constituent of Petasites japonicus leaves22. This plant is generally cultured in Eastern Asia for its use as both a vegetable and a folk-based medical remedy. Petasites japonicus is traditionally used to treat various diseases, including headaches, chronic cough, fever and asthma. Bioassay studies have demonstrated that Petasites japonicus extracts and compounds have anti-oxidant, anti-inflammatory and anti-tumor based biological effects23,24. Previously, we showed that Petatewalide B isolated from Petasites japonicus has both anti-allergenic and anti-inflammatory effects22. Furthermore, sesquiterpenoids from Petasites japonicus are known to exhibit neuroprotective properties towards human neuroblastoma SH-SY5Y cells20,21. However, the effect of the AMPK/Nrf2 signal on Petatewalide B-mediated anti-neuroinflammatory properties has not been reported so far. This is the first study to identify the crosstalk between Petatewalide B isolated from Petasites japonicus and the up-regulation of the AMPK/Nrf2/ARE signal, which can attenuate the neuroinflammatory response in microglia. In this study, we have demonstrated the anti-neuroinflammatory properties of Petatewalide B towards LPS-induced neuroinflammatory responses. Petatewalide B attenuated the production of NO, IL-1β, IL-6 and TNF-α, and the expression of iNOS. In addition, a detailed molecular mechanism investigation helped us demonstrate that AMPK plays a definitive role in inducing the anti-neuroinflammatory properties of Petatewalide B, by up-regulating the transcription factor Nrf2 and its downstream expression of HO-1 and NQO1. The schematic mechanism underlying the anti-neuroinflammatory properties of Petatewalide B has been described in Figure 5.