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Medicinal Plants for Eczema
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Olea europaea L. subsp. africana (Mill.) P. S. Green (Figure 5.4), commonly known as the olive tree, is part of the Oleaceae family and is mainly found within the eastern regions of Africa and extends toward the southern tip of the continent (Lall and Kishore, 2014; Cuneo and Leishman, 2006). This small evergreen tree is found in woodland and mountain habitats and has a distinctive purple-black fruit color (Cuneo and Leishman, 2006). Olea europaea is one of the oldest cultivated trees, dating back to around 7,000 years ago. These plants were mainly cultivated for commercial purposes; however, the oils were known for their medicinal properties (Hashmi et al., 2015).
The Treatment of Hypertension with Nutrition, Nutritional Supplements, Lifestyle and Pharmacologic Therapies
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
OLE has a dose-dependent reduction in both office BP measurements and 24-hour ABM with a range of 4/3–11/5 mmHg with [165–167,171]. A total of 60 prehypertensive male subjects in a 6-week study with OLE demonstrated a reduction in BP about 4/3 mmHg [165]. Leaf extract of olive (Olea europaea), at the dosage regimen of 500 mg twice daily, was similarly effective in lowering SBP and DBP in subjects with stage 1 hypertension compared to captopril, given at its effective dose of 12.5–25 mg twice daily (reduction of about 11/5 mmHg) [167].
Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
The olive tree (Olea europaea, family Oleaceae) is native to the Mediterranean region, tropical and central Asia, and various parts of Africa. It is widely cultivated for its fruit and oil (122). There are three kinds of olive fruits: green olive, black olive, and brown semi-ripe olive. Raw or fresh olives are bitter and rarely consumed. They are often prepared by fermentation in order to remove the bitter taste caused by a phenolic compounds present in the raw fruit. Fermented olive fruits are called table olives and become flavored and tasty. However, they are rich in salt, which is not good for people with high arterial blood pressure. In contrast, pure olive oil extracted from fresh fruit is good for health.
Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile
Published in Pharmaceutical Biology, 2022
Khaled Ahmed Mansour, Ahmed Elbermawi, Ahmed A. Al-Karmalawy, Mohamed-Farid Lahloub, Mona El-Neketi
Oleaceae (the olive family) includes 28 genera and about 900 species (Akhtar et al. 2021). It is well-known for its multiple nutritional, perfumery, and horticultural uses. Moreover, oleaceous plants are widely used as traditional treatments. In Belarus, the buds of Syringa vulgaris L. are processed into wine and used for the treatment of joint pain. In Southern Italy, the bark of Fraxinus ornus L. is often used as antidiarrheal and hypocholesterolemic. The fruits of the Chinese tree Ligustrum lucidum W.T. Aiton are used to improve both liver and kidney functions. In Greece, the leaves of Olea europaea L. are used as hypotensive. The volatile oil extracted from O. europaea is used as an antirheumatic and used as a laxative in Oman. In addition, olive oil has been reported to have both anticancer and antioxidant effects (Huang et al. 2019; El Haouari et al. 2020; De Bruno et al. 2021).
Oleanolic Acid Suppressed DMBA-Induced Liver Carcinogenesis through Induction of Mitochondrial-Mediated Apoptosis and Autophagy
Published in Nutrition and Cancer, 2021
Samar Hosny, Heba Sahyon, Magdy Youssef, Amr Negm
The limited conventional therapy of liver cancer are connected with high morbidity and mortality rate, suggesting imperative requests for introduction of novel efficient therapeutic drugs (7,8). Nutritional supplements of plant sources are currently being investigated for their use in the prevention and reversion of cancer progression (8). OA is a pentacyclic triterpenes with a wide spread occurrence throughout the plant kingdom. Oleanolic acid exists in olives (Olea europaea L.) and their products, as olive oil. It is estimated that the average daily intake of oleanolic acid in the Mediterranean diet, which includes olives and olive oils, is around 25 mg. Other foods such as various legumes that contain oleanolic acid are in the range of 0.251–2.591 µg/g fresh weight (9,10). High amounts of oleanolic acid are also present in edible parts of jujube (Ziziphus jujube Mill.) (11).
Inhibitory Effects of Olea europaea Leaf Extract on Mesenchymal Transition Mechanism in Glioblastoma Cells
Published in Nutrition and Cancer, 2021
Melis Mutlu, Berrin Tunca, Secil Ak Aksoy, Cagla Tekin, Unal Egeli, Gulsah Cecener
Some medicinal herbs have become new frontiers for the progress of cancer therapies because of their natural phytochemicals and phytonutrients. The olive tree (Olea europaea) widely grows remedies in European and Mediterranean countries, including Turkey and Olea europaea leaf extract (OLE) often used as a strong anti-oxidant and anti-hypertensive as a conventional drug (14). OLE contains bioactive components, such as plenty of secoiridoid, tripertene and flavonoids, and the most important bioactive component contained in this extract is oleuropein which is secoiridoid. The antitumoral properties of OLE have been discussed in previous work and in these works leukemia, colon, melanoma and breast cancer cell lines were evaluated and this plant extract has been shown to have anti-proliferative and apoptotic effect (15, 16). In our previous works, it was determined that OLE decreases cell proliferation, killing cells both apoptotic and necrotic, increasing the MGMT methylation rate, increasing the activity of TMZ, decreasing angiogenesis, increasing the efficiency of bevacizumab and affecting miRNA expression as epigenetic effect in the GB and GB stem cells (17–20). However, the effects of OLE on the MT mechanism of the tumor in relation to reducing the aggressiveness of GB are unknown. Therefore, the present study aimed to investigate the effect of OLE, TMZ and combination with each other on the OLE potential for inhibiting cell migration and MT activity in GB cells.