Obovatol

Obovatol

Herbs with Antidepressant Effects

Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019

The bark of the Magnolia officinalis tree is the major source of its medicinal phytochemicals. Among these chemicals, magnolol and its isomer, honokiol, are the most important. Other substances isolated from the bark are magnolianone, erythro-honokitriol, threo-honokitriol, magnaldehyde, magnatriol, randaiol, obovatol, magnolignan B, p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside.3

Application of the Mannich reaction in the structural modification of natural products

View Article

Journal Information

Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023

Miao-Xia Pu, Hong-Yan Guo, Zhe-Shan Quan, Xiaoting Li, Qing-Kun Shen

Obovatol, a novel lignan bearing a diphenyl ether skeleton, exhibits a wide range of biological activities, including antifungal76, anti-tumor77, anti-inflammatory78, anxiolytic79, anti-platelet80, and anti-AD activities81. The biological activity of obovatol can be significantly improved by introducing active groups at the ortho position of the phenolic hydroxyl group82. Yang et al.83 designed and synthesised a series of C-4-aminomethylated derivatives of obovatol as lead compounds through the Mannich reaction. Inhibition of spore germination and mycelial growth by these derivatives has been investigated against several phytopathogenic fungi.

Explore chapters and articles related to this topic

Herbs with Antidepressant Effects

Application of the Mannich reaction in the structural modification of natural products