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Aminocaproic Acid
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Polymerized aminocaproic acid is used in nylon, which has caused a case of non-pharmaceutical sensitization to ACA. The patient, who developed scaly erythema on her trunk from wearing nylon body stocking, reacted to 3% and 6% aminocaproic acid pet. (8). Another female patient sensitized to aminocaproic acid from eye drops experienced occasional dermatitis on her legs after wearing nylon stockings. It was hypothesized that this was caused by aminocaproic acid monomer released into sweat from the stockings (11).
HLA-DR and -DQ Serotyping
Published in M. Kam, Jeffrey L. Bidwell, Handbook of HLA TYPING TECHNIQUES, 2020
The majority of laboratories in the U.K. carrying out serological typing for class II antigens currently use immunomagnetic beads to separate out HLA-DR positive cells. This method is preferred because it can consistently produce typeable B cell preparations from blood samples from patients. Nylon wool and SRBC methods for obtaining B cells can produce satisfactory results, but result in more HLA class II typing failures with patient samples than do the immunomagnetic beads. A particular drawback of the SRBC technique is that B cells are not positively selected. The greater success rate for immunomagnetic beads counterbalances the higher cost of reagents and equipment required to carry out this technique as compared to the nylon wool and SRBC methods.
Animal Models for Investigations of Biomaterial Debris
Published in Yuehuei H. An, Richard J. Friedman, Animal Models in Orthopaedic Research, 2020
Martin Lind, Yong Song, Stuart B. Goodman
In muscle tissue, necrotic muscle fibers were seen in relation to particles, which evoked a macrophagic reaction. At later time points up to 12 months, necrosis disappeared and foreign body giant cells predominated. Foci of plasma cells and lymphocytes were very evident at 12 months, typically located adjacent to clumps of particulate material. Giant cells were replaced by fibroblasts at late time points from 12 month for PE particles. Nylon particles were removed and not seen after 18 months. In knee joints, particulate PMMA was accumulated in synovial tissue as early as after two weeks. At two and four weeks the particles were primarily surrounded by macrophages. At later time points particles were surrounded by a fibrous stroma with islands of foreign body giant cells. Small foci of plasma cells and lymphocytes were seen at 18 and 24 months. The joint cartilage was unaffected by particle implantation at all time points. PE and nylon particles gave similar synovial reactions.
Preparation and in vivo evaluation of an intravenous emulsion loaded with an aprepitant-phospholipid complex
Published in Drug Delivery, 2023
Yan Li, Hong Yin, Chensi Wu, Jia He, Chunyan Wang, Bo Ren, Heping Wang, Dandan Geng, Yirong Zhang, Ligang Zhao
The sterilization method had a significant effect on the characterization and appearance of the APT-IE system. After moist heat autoclaving, the physical properties and appearance of the samples were obviously changed: the color of APT-IE became dark, the liquidity decreased, and some demulsification occurred. Additionally, the drug content and pH value of APT-IE decreased significantly. This result happened may due to the decomposition of phospholipids at high temperature and an increase of free fatty acids. However, no significant changes in appearance, particle size, drug content, and pH value were found after APT-IE sterilized by a 0.21 μm Nalgene® nylon filter. Therefore, the poor compatibility between APT cannot tolerate humid heat autoclaving (Zhang et al., 2020), but it can be sterilized by a 0.21 μm Nalgene® nylon filter.
Orbital inflammation in the setting of a nylon foil implant
Published in Orbit, 2022
Adrianna D. Jensen, Nickisa M. Hodgson, Rupin Parikh, Charles G. Eberhart, Amanda D. Henderson, Roxana Fu
To our knowledge, this is the first reported case of such a prominent inflammatory reaction to Supramid® nylon, which has been available and in use since the 1960s. In a retrospective chart review of 41 patients receiving Supramid® implants, Custer et al.1 reported five patients with complications thought to be the direct result of implant placement, with increased risk in those patients with larger implants, increased time between fracture and repair, and history of prior surgery in the orbit. These complications included four cases of hematoma and one case of Streptococcus pneumoniae abscess in the setting of sinusitis – but notably no cases of fibroinflammatory or other soft tissue mass. The implant capsule in patients with hematoma demonstrated some inflammation on histology, perhaps leading to the growth of vessels in the capsule that subsequently bled. The authors noted that the histologic findings could represent inflammation in response to the nylon; however, they felt the complications were more likely related to the implant capsule than to the nylon sheet itself.
The comparison of skin rejuvenation effects of vitamin A, fractional laser, and their combination on rat
Published in Journal of Cosmetic and Laser Therapy, 2019
Yan Qu, Ying Wang, Yan Zhang, Chunyu Han, Dong Gao, Waishu Jin, Jinning Liang, Xiujuan Xia
The engineering bacteria established previously containing type III pre-collagen, miR-29a, Akt, and TGF-β gene fragments were incubated and amplified, plasmids were extracted and digested with enzymes, and then purified to obtain relevant target fragments. Then the target fragments were prepared into radiolabeled probes with [a-32P]-dATP. The total RNA extracted from the skin tissue samples was denatured and then immobilized onto nylon membrane. Then the nylon membrane containing the spots of total RNA was put into a hybridization flask, into which radiolabeled probes containing target fragments were added, and then hybridization was performed in a hybridization oven. After hybridization and membrane washing, the nylon membrane was covered with a freshness-keeping plastic film which could be penetrated by ultraviolet rays. The autoradiography was done under −70℃. X-ray photo was prepared after 1–7 days of exposure, the hybridization results were observed and detected to determine the expression changes of mRNA of type III pre-collagen, miR-29a, Akt, and TGF-β at different time points in different regions.