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Medicinal Plants Against COVID-19
Published in Hanadi Talal Ahmedah, Muhammad Riaz, Sagheer Ahmed, Marius Alexandru Moga, The Covid-19 Pandemic, 2023
Binish Khaliq, Naila Ali, Ahmed Akrem, M. Yasin Ashraf, Arif Malik, Arifa Tahir, M. Zia-Ul-Haq
Crocin compound was isolated from C. sativus and have the remarkably antiviral activity. Crocin inhibit the replication of human coronavirus and reduced the symptoms of the disease in the infected people. C. sativus is medicinal herbs and is being used to treat the HIV and human coronavirus [99]. Nerium oleander is also herbal medicinal plants that have 11.25% digitoxigenin compound and its derivatives. These compounds and their derivatives have the anticancer and antiviral activity [100]. Lauris nobilis herbal plants contain the ß Eudesmol compounds in low quantity, i.e., 2.39%, but this compound has a very good potential to interact with the target and showed the antibacterial antiviral activity against the different bacterial and viral diseases [101]. Docking results of these three compounds with the Coronavirus main proteases inhibited the binding site of Coronavirus main protease and controlled the replication of Coronavirus main protease [102].
Anti-Inflammatory Properties of Bioactive Compounds from Medicinal Plants
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Health Benefits of Secondary Phytocompounds from Plant and Marine Sources, 2021
Muhammad Imran, Abdur Rauf, Anees Ahmed Khalil, Saud Bawazeer, Seema Patel, Zafar Ali Shah
Natural extracts of Aloe barbadensis (@0.5%, 1%, and 2%) administrated in diet for a period of fifteen days resulted in noteworthy elevation of macrophages contents that are accountable for phagocytic action in tissues [10]. Aloe vera-based Nerium oleander extracts increased antioxidative protection, protected cell viability, and intracellular reduced glutathione and significantly decreased the formation of ROS [80]. Similarly in propagation of RAW 264.7 cells, Aloe-emodin markedly inhibited IL-6, NO, and IL-1β formation, without any cytotoxicity. Expression levels of mRNA for IL-6, iNOS, and IL-1β genes were retarded by administration of Aloe-emodin. Analysis of Western blotting revealed suppressing behavior of aloe-emodin against LPS-activated expression of iNOS protein, degradation of IκBα and JNK, p38, ERK, and Akt phosphorylation [29].
A comprehensive review of cardiotoxic effects of selected plants
Published in Toxin Reviews, 2021
Akbar Anaeigoudari, Nahid Azdaki, Mohammad Reza Khazdair
Nerium oleander is an ornamental shrub that is frequently grown as an attractive plant in gardens and public city areas. The flowers of N. oleander are fragrant, funnel-shaped, with white to pink to deep red colors (Figure 3). This plant has been distributed in the subtropical Asia, and Mediterranean region. Recently it is grown in USA, Australia, China, and Middle East countries (Derwich et al.2010). The potential toxic effects of all parts of the plant on animal and human body were reported (Farkhondeh et al.2020). The main constituents isolated from leave extract of N. oleander are, Octadecane, 3-ethyl-5–(2-ethylbutyl), Monolinoleoylglycerol trimethylsilyl ether, Eicosene and Cyclohexen-1-one (Hameed et al.2015). In addition, the seeds of plant contain glucosides including; oleandrine, odorosides, adigoside), and the bark of N. oleander also contains glucosides including; rosaginoside, nerioside, corteneroside (Zibbu and Batra 2010).
Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish
Published in International Journal of Neuroscience, 2020
İsmail Ünal, Esin Çalışkan-Ak, Ünsal V. Üstündağ, Perihan S. Ateş, Ahmet A. Alturfan, Meric A. Altinoz, Ilhan Elmaci, Ebru Emekli-Alturfan
In the MTT experiment, when mitoquinone and oleandrin were administered as neuroprotective agents against rotenone toxicity, both agents increased mitochondrial activity. Oleandrin is a cardiac glycoside that binds and inhibits Na +/K + -ATPase. Recently, new roles of cardiac glycosides in the regulation of various cellular processes have been demonstrated. Leaves and flowers have been reported to be cardiotonic, diuretic, anticancer, antibacterial, anti-fungal and expectorant [36]. In recent years, Nerium oleander has been reported to have neuroprotective activity as the herbal anticancer candidate ‘PBI-05204’ due to its oleandrin content [9]. The neuroprotective effect of oleandrin content of PBI-05204 has been suggested to be due to its neural BDNF expression enhancing effect [10].
Yellow Oleander Seed, or “Codo de Fraile” (Thevetia spp.): A Review of Its Potential Toxicity as a Purported Weight-Loss Supplement
Published in Journal of Dietary Supplements, 2018
Armando González-Stuart, José O. Rivera
Yellow oleanders are attractive ornamental shrubs or medium-sized (3–9 meters tall) trees with bright yellow-orange flowers and milky latex. These species are originally from the American tropics, from Mexico to Peru and Venezuela, but are cultivated in various tropical and subtropical areas around the world, including southern India and Sri Lanka. Some of the most important species include Thevetia peruviana, T. thevetioides, and T. ovata, among others. These plants belong to the Apocynaceae botanical family, long known to include various poisonous species, including Oleander (Nerium oleander), among many others (Quattrocchi, 2012; Mabberley, 2008; Wagstaff, 2008). Thevetia peruviana (Syn. Cascabela thevetia) is a medium-sized tropical shrub or small tree that grows to a height of 4 to 6 meters (Figure 1). The leaves are spear shaped and up to 15 cm in length. The orange-yellow funnel-shaped flowers are 50–60 mm in length and have an approximate diameter of 24–35 mm. The fruit (Figure 2) can be 20–27 mm in length and 28–30 mm in width, containing four flattened winged seeds (McKenzie, 2012).