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Advances in Nanonutraceuticals: Indian Scenario
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Amthul Azeez, Mubeen Sultana, Lucky, Noorjahan
Regularly used foodstuffs and beverages are considered to contain substantial amounts of natural ingredients that qualify them to regard as nutraceuticals, which are believed to promote robust growth and overall good health. Nutraceuticals are not some exotic compounds but naturally occurring phenols, abundantly found in food items, such as green tea, red berries and in different types of spices. Most of these active phenolic compounds are known to treat amyloid neurodegenerative disorders. Apart from these regular foods, a number of other routinely used in cuisine, such as flax seed oil (tocotrienols), carrots (carotenoids), turmeric (curcumin) all contain one or other form of bioactive compounds, which may be recognised as nutraceuticals. Fruits, vegetables, and seafood also contain abundant quantiles of omega fatty acids; allyl-sulphides found in garlic, beta-glucans of mushrooms/cereals are some of the examples of natural compounds that can be considered for the synthesis of nutraceuticals. Nuts contain fatty acids and are also rich in polyunsaturated fatty acids (PUFA) that can help limit cholesterol. Egg shells are a rich source of calcium carbonate and calcium powder that is derived from these shells can be used as a calcium supplement to treat calcium deficiency (Josef & Katarina 2019). There are quite a number of studies that show convincing results, illustrating that certain bioactive compounds present in soya bean, garlic, ginger, green tea and honey are known to have an apoptotic (programmed cell death) effect on cancer cells and hence these natural substances may aid in preventing chemotherapy for the treatment of cancer and therefore be recommended as an ancillary remedy along with standard cancer treatment protocols. As there are quite a number of valuable, active molecules being identified as anticancer agents in the commonly used food, these food-based nutraceuticals have caught the imagination of scientific researchers. The reason for this widespread clamor for nutraceuticals for cancer therapy is due to is their easy accessibility, high degree of absorption and transformation, which leads to the easy availability of the compound in the biological system. One such example is worth mentioning, wherein neem is used via cinnamon oil, which acts as a lipophilic agent to convey vitamin D to the lungs, where it has been identified to treat alveolar carcinoma cells in humans and hence vitamin D qualifies to be used in the food industry as well as processed to be an anticancer nutraceutical.
Influence of phenolic acids on the storage and digestion stability of curcumin emulsions based on soy protein-pectin-phenolic acids ternary nano-complexes
Published in Journal of Microencapsulation, 2019
Bei Jin, Xiaosong Zhou, Shanshan Zhou, Yuan Liu, Risheng Guan, Zhiyuan Zheng, Yuxin Liang
Phenolic acids are naturally occurring phenol found in many fruits and vegetables with excellent anti-inflammatory and antioxidant properties. Also, they are naturally abundant, biocompatible and have high chemical stability (Jakobek 2015). As a result, phenolic acids are attracting more and more attentions and have become popular in the design of functional food products. Recently, the incorporation of phenolic acids in protein-polysaccharide complexes was expected to improve their physical and thermal stability and delivery performance (Liu et al.2017). Additionally, phenolic acids with different structures were found to effect the interaction between polysaccharides and phenolic acids and subsequently alter the antioxidant capability of the conjugates (Ahn et al.2017). Similarly, phenolic acids with different structures could cause the conformational change of protein, and influence the interaction behaviours between proteins and phenolic acids (Liu et al.2018). However, there are few reports about the effect of phenolic acids type on the emulsify properties of ternary complexes up to now.
The natural plant compound carvacrol as an antimicrobial and anti-biofilm agent: mechanisms, synergies and bio-inspired anti-infective materials
Published in Biofouling, 2018
Anna Marchese, Carla Renata Arciola, Erika Coppo, Ramona Barbieri, Davide Barreca, Salima Chebaibi, Eduardo Sobarzo-Sánchez, Seyed Fazel Nabavi, Seyed Mohammad Nabavi, Maria Daglia
M. tuberculosis is a thin, slightly curved bacillus which is the etiologic agent in the majority of tuberculosis cases. Alokam et al. (2014) studied the in vitro anti-tubercular activity of some naturally occurring phenols (CAR, THY, menthol, (±) neo-isopulegol, EUG and vanillin) and various CAR derivatives. CAR exhibited excellent M. tuberculosis inhibition with an IC of 1.6 ± 0.4 μM and an MIC of 60 μM, while the other natural compounds and CAR derivatives were found to be less potent (IC50 ranged from 13.63 ± 1.4 μM to 28.28 ± 1.7 μM). It is important to note that the first line anti-tubercular drugs (isoniazid, rifampicin and ethambutol) were more potent that the natural compounds studied (MIC: 0.66 μM, 0.23 μM and 15.31 μM, respectively). Furthermore, AL-Ani et al. (2015) studied the effects of CAR against three non-tuberculosis, fast-growing mycobacteria reference strains (M. smegmatis ATCC 19420, M. fortuitum ATCC 6841 and M. phlei ATCC 11758), which have a similar cell wall structure as the pathogen M. tuberculosis. These strains exhibited a MIC of CAR ranging from 80 μg ml−1 (M. smegmatis and M. phlei) to 100 μg ml−1 (M. fortuitum).
Development and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for curcumin transdermal delivery: an anti-inflammatory exposure
Published in Drug Development and Industrial Pharmacy, 2019
Mohammad A. Altamimi, Mohsin Kazi, Mshaan Hadi Albgomi, Abdul Ahad, Mohammad Raish
Curcumin (CUR) is a naturally occurring phenol that is responsible for the yellow color of the rhizome of the plant Curcuma Longa Linn. The IUPAC name of curcumin is (1E, 6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione with a chemical formula of C21H20O6 (Figure 1(a)) [1].