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Ruthenium Anticancer Drugs
Published in Astrid Sigel, Helmut Sigel, Metal Ions in Biological Systems, 2004
Enzo Alessio, Giovanni Mestroni, Alberta Bergamo, Gianni Sava
Lung metastases of experimental solid tumors are markedly reduced following treatment with NAMI-A and many other ruthenium analogs (Table 1) [13–16]. Selected NAMI-A-type complexes show a pharmacological activity very similar to that of NAMI-A: in vitro they are devoid of meaningful cytotoxicity against tumor cells, and in vivo they inhibit metastasis formation and growth approximately to the same extent as NAMI-A. Metastasis reduction is not simply due to prevention of their formation since the same degree of reduction is observed either when mice are treated during the initial phases of tumor growth and dissemination or when they are given the compound at stages of advanced growth of the primary tumor or even after surgical removal of the primary tumor, when only secondaries in the lungs are present (Table 2) [13,14,38]. The effects of NAMI-A on metastases do not strictly depend on the dose, schedule and route of administration (Table 3) [39,40].
Reducing stigma and increasing competence working with mental illness: Adaptation of a contact-based program for osteopathic medical students to a virtual, active learning format
Published in Medical Education Online, 2023
Julia R. Van Liew, Chunfa Jie, Jeritt R. Tucker, Lisa Streyffeler
Although originally designed for practicing health-care professionals, the NAMI PEP is a promising program for medical students. It incorporates each of the above-referenced optimal conditions for contact-based education and offers inherent implementation and scale potential as a standardized program with existing delivery infrastructure through NAMI affiliates in communities across the USA. In a non-randomized, controlled trial in a self-selected medical student sample, the NAMI PEP was associated with improved affect, beliefs, and behaviors towards patients with MI at one-week and 3-month follow-up [22]. While this study demonstrated initial efficacy for implementing the NAMI PEP within medical students, its brief follow-up period, elective student sample, and primary use of traditional passive learning approaches (e.g., instructors reading material aloud to students) precluded broader implications for integration and dissemination in contemporary medical education.
Mental health for LGBTQI people: a policies' review
Published in International Review of Psychiatry, 2022
Antonio Ventriglio, Massimo Mirandola, Gian Maria Galeazzi, Francesco Amaddeo, Federica Pinna, Manlio Converti, Andrea Fiorillo
Mind is a mental health charity, founded in England in 1946 as the National Association of Mental Health (NAMH), offering information and advice to people with mental health problems in order to raise public awareness and understanding of mental health issues. In particular, it delivers a webpage reporting information and advices on LGBT mental health issues (Mind, 2022). The Mental Health America (MHA), founded in 1909, is the US leading community-based non-profit dedicated to addressing the needs of those living with mental illness and promoting the overall mental health of all. The foundation provides a detailed webpage including epidemiological data on LGBT mental health, societal issues, insurance and access to services, treatments issues and educational material (MHA, 2022). Similarly, the Mental Health Foundation, founded for supporting prevention in mental health, delivers mental health statistic and supportive information and advice for LGBT people suffering from mental health issues (MHF, 2021). The National Alliance on Mental Illness (NAMI) is the US largest grassroots mental health organisation providing advocacy, education, support and public awareness so that all individuals and families affected by mental illness can build better lives. Values of the organisation are hope, inclusion, empowerment, compassion and fairness; a particular concern is directed to LGBT community and those members affected by mental illness (NAMI, 2021).
Novel strategies for the fight of Alzheimer’s disease targeting amyloid-β protein
Published in Journal of Drug Targeting, 2022
Yang Xie, Yan Wang, Shangfei Jiang, Xiaohong Xiang, Jianhua Wang, Linhong Ning
In addition, another metal complex (ruthenium) was accepted as a potential anti-AD agent, which was developed as alternatives to platinum complex [64,65]. Studies focussed on a number of ruthenium complexes-based drugs targeting Aβ were carried out for seeking AD therapeutic drug candidates [66,67]. In particular, Jones and co-workers investigated the anti-amyloid activities of ruthenium complex KP1019 (Figure 4), which is also a widely studied anti-cancer agent [68]. The result showed that KP1019 did prevent in vitro human nerve cell from Aβ-induced neurotoxicity via inhibiting the formation of Aβ aggregates and dissembling preformed Aβ aggregates, which was enabled by binding to histidine residues of Aβ. Recently, Storr’s research group reported a series of ruthenium complexes derived from NAMI-A with the imidazole ligand substituted for pyridine derivatives, also showed potential in modulating the aggregation of Aβ [69]. Besides, Kumbhar and co-workers investigated a range of ruthenium polypyridyl complexes with enhanced inhibitory effect against Aβ aggregation by tetra-xylene bipyridine glycoluril [67]. Furthermore, metal complexes (such as iridium and cobalt) also showed binding affinity with Aβ and exhibited inhibition potential for AD therapy [70,71].