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Glove Selection for Work with Acrylates Including Those Cured by Ultraviolet, Visible Light, or Electron Beam
Published in Robert N. Phalen, Howard I. Maibach, Protective Gloves for Occupational Use, 2023
The innovation in medicine of the last few decades has resulted in more uses of methacrylates in different medical procedures, which has increased the chances for medical personnel to be exposed to acrylates, especially methyl methacrylate (MMA).19 Acrylate adhesives are, for example, extensively used in surgery as they are an important class of medical adhesives, with applications such as bone cement (i.e., methyl acrylate) as well as liquid skin or tissue sutures or wound-care products (i.e., cyanoacrylate).19–21 Acrylates are also extensively used in surgical reconstruction or replacement of joints or on prosthetic limbs.19,21
Histological Study in Orthopaedic Animal Research
Published in Yuehuei H. An, Richard J. Friedman, Animal Models in Orthopaedic Research, 2020
Helen E. Gruber, Audrey A. Stasky
As with all bone histologic studies, a sampling site must be identified clearly and the sections obtained in the appropriate plane with minimum artifact during gross specimen harvest. At tissue harvest, the gross features of nearby tissue reaction, encapsulation, or other tissue responses should be noted and photographically documented. Radiographic documentation at harvest is also often very important. Large specimens require the appropriate lengthened infiltration regimes for methacrylate embedding.
Contact Urticaria and Eczema from Dental Products
Published in Ana M. Giménez-Arnau, Howard I. Maibach, Contact Urticaria Syndrome, 2014
The first reports on eczema and urticaria from dental products have been published many decades ago. In this regard, Hensten-Pettersen provided an interesting historical overview.[1] In the first reports of occupationally related dermatoses in dental personnel, local anesthetics, disinfectants, including eugenol, and hand-washing have been identified as the principal causative agents. Several decades later, in the 1950s, methacrylates were introduced in the dental materials market. Within few years, in 1954, Fisher and Woodside [2] described the first cases of occupational contact sensitization to methacrylate monomers in dental personnel. Since then, the number of case reports and studies on occupational contact dermatitis and urticaria from dental products has increased rapidly and numerous chemicals have been identified as causative agents. The rapid developments of new dental products and the subsequent introduction of new chemicals into these products imply a constant update of newly identified allergens and irritants of this field. This chapter will provide an up-to-date overview and give advice on allergological testing.
The most promising microneedle device: present and future of hyaluronic acid microneedle patch
Published in Drug Delivery, 2022
Huizhi Kang, Zhuo Zuo, Ru Lin, Muzi Yao, Yang Han, Jing Han
MeHA is highly hydrophilic and can swell rapidly within minutes. A swelling rate of approximately 600% can be achieved in vitro in 30 seconds (Park et al., 2022). Therefore, in addition to transdermal drug delivery, it can also be applied to the immediate extraction of biomolecules from tissue fluids for analysis, such as glucose and cholesterol (Chang et al., 2017). The swelling rate can be adjusted by adding a suitable photo-initiator to control the UV exposure time. Cross-linking time was inversely proportional to swelling rate and drug-carrying capacity (Chew et al., 2020). MeHA not only enhances the mechanical strength of MNP and extends the duration of skin microchannels, but also produces a longer peak time of drug action Tmax and a higher peak concentration of drug Cmax. The degree of methacrylate can be adjusted according to treatment needs. The degree of cross-linking has a great impact on the mechanical strength of MNP. MNP varies greatly in morphology and properties depending on the concentration of MeHA (Yao et al., 2021), and this review lists several different MeHA-prepared HA MNP. HA MNP prepared with MeHA can be used for diagnostic extraction and transdermal delivery (Table 5).
Fabrication of a dual stimuli-responsive magnetic nanohydrogel for delivery of anticancer drugs
Published in Drug Development and Industrial Pharmacy, 2021
Bakhshali Massoumi, Rogayeh Mossavi, Sanaz Motamedi, Hossein Derakhshankhah, Somayeh Vandghanooni, Mehdi Jaymand
The N,N′-(dimethylamino)ethyl methacrylate (DMAEMA) monomer was supplied from Sigma-Aldrich, dried over calcium hydride, distilled under vacuum, and stored at −20 °C before use. Maleic anhydride (MA), cystamine dihydrochloride (Cys.2HCl), sodium hydroxide (NaOH), 2,2′-azobis(isobutyronitrile) (AIBN), ferrous chloride tetrahydrate (FeCl2·4H2O; 99%), ferric chloride hexanhydrate (FeCl3·6H2O; 98%), 3-(trimethoxysilyl) propylmethacrylate (MPS), and NH4OH (25% of ammonia) were purchased from Sigma–Aldrich. Biological reagents, including fetal bovine serum (FBS), phosphate-buffered saline (PBS), and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphe-nyltetrazolium bromide) powder were supplied from Invitrogen. Methotrexate (MTX) was provided from EBEWE Pharma.
A three-year randomized clinical trial evaluating direct posterior composite restorations placed with three self-etch adhesives
Published in Biomaterial Investigations in Dentistry, 2021
Joseph Sabbagh, Layal El Masri, Jean Claude Fahd, Paul Nahas
This randomized trial was a single-site study conducted at university dental clinics in the Department of Restorative and Aesthetic Dentistry, Faculty of Dental Medicine, Lebanese University, Lebanon. The study was designed according to the Consolidated Standards of Reporting Trials (CONSORT) statement (Figure 1). A consent form and the protocol were submitted, reviewed and approved by the Ethical Committee of the Lebanese University. All procedures were performed according to the ethical standards of the institutional and/or national research committee and world medical association Declaration of Helsinki [16]. Selected patients were assessed for eligibility for participation, using the following inclusion criteria: (1) teeth with shallow to moderate Class I or II carious lesions, (2) a good periodontal status, (3) the absence of pulp pathology, (4) the absence of restorations on selected teeth, (5) the absence of parafunctional habits, (6) the included teeth were vital. Patients were healthy, physically and mentally with a non-compromised medical history and with the absence of allergic history to methacrylate. Patients that did not fit any of these criteria were excluded from the study. They were informed with the clinical procedure and signed an informed consent form.