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Effects of Environmental Factors on the Endocrine System
Published in George H. Gass, Harold M. Kaplan, Handbook of Endocrinology, 2020
There are many chemicals known to induce testicular toxicity either directly or indirectly. They include analgesics such as indomethacin and morphine, androgens and their antagonists, antibiotics such as amphotericin B, insecticides such as DDT and parathion, some food additives such as cyclamates, metanil yellow, and caffeine, heavy metals, etc.
Evening primrose oil attenuates oxidative stress, inflammation, fibrosis, apoptosis, and ultrastructural alterations induced by metanil yellow in the liver of rat: a histological, immunohistochemical, and biochemical study
Published in Ultrastructural Pathology, 2023
Amany Mohamed Shalaby, Rania H. Shalaby, Mohamed Ali Alabiad, Doaa I. Abdelrahman, Mohammed Alorini, Fatima A. Jaber, Shaimaa Mohamed Abdelfattah Hassan
Food additives are widely employed in food to enhance the aroma, color, and quality of foods in order to increase consumer acceptability.1 Different types of dyes are utilized as food colorants and additives. The yellow azo dye, metanil yellow (Myl) is widely employed in food coloring.2 Myl can be used in industries to color wool, nylon, silk, paper, ink, aluminum, detergent, and other materials. This dye is not approved for food products as it is poisonous and categorized as a CII group drug by the Joint FAO/WHO Expert Committee on Food Additives. However, because it is a cheap colorant, it is extensively employed as a coloring ingredient in many foods, such as ice creams, sweetmeat, and soft drinks.3,4 It is also mixed with turmeric powder to replicate the look of curcumin.5
Cinnamaldehyde attenuates kidney senescence and injury through PI3K/Akt pathway-mediated autophagy via downregulating miR-155
Published in Renal Failure, 2022
Prior studies have revealed that cinnamaldehyde antagonizes glomerular fibrosis and renal dysfunction in diabetic mice [19] and restores kidney enzyme activities and kidney function in metanil yellow-administrated rats [41], indicating a renoprotective role of cinnamaldehyde. Kidney senescence is a physiologic or pathological process that causes a higher risk for structural and functional changes in the kidney [1]. This study confirmed that cinnamaldehyde could exert similar anti-senescence and anti-injury effects on the kidney to almost the same extent as VE and it also generated an inhibitory effect on senescence-associated autophagy through downregulating miR-155 expression. Besides, the current study unearthed a novel signaling pathway, PI3K/Akt, the decreased phosphorylation of which could strengthen D-gal-induced autophagy as well as kidney senescence and injury in vivo and in vitro.