China
Africa
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The Antidepressant Effects of Yueue and the Herbs of Traditional Chinese Medicine
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Descriptions of studies in English are wanting. However, at least one English abstract of a study states that Gui pi in combination with Gan mai da zo (described above) was as effective in treating depression and insomnia as zolpidem plus deanxit, the combination of flupentixol and the tricyclic antidepressant, melitracen.24
Psychopharmacology in gastrointestinal cohorts
Published in Simon R. Knowles, Laurie Keefer, Antonina A. Mikocka-Walus, Psychogastroenterology for Adults, 2019
Elspeth Carruthers, Julian Stern
Several reviews have concluded that olanzapine is safe and effective for the treatment and prophylaxis of nausea and vomiting, especially in chemotherapy [55]. A small RCT of flupenthixol and melitracen for FD found a significant improvement in global symptoms compared with placebo, and a systematic review of FD treatment found that antipsychotics such as levosulpiride conferred some benefit versus placebo [56, 57]. Quetiapine has also shown some benefit for GI symptoms in severe refractory FGIDs [32].
Toxicological exposures reported to a telephonic consultation service at a tertiary care hospital in Lebanon
Published in Clinical Toxicology, 2020
Eveline Hitti, Tharwat El Zahran, Hani Hamade, Rima Kaddoura, Zeina Mneimneh, Brent W. Morgan, Ziad Kazzi
This study highlights other areas that warrant evaluation by policy makers or future research. Deanxit (brand name) was reported in 13 cases (2.7% of total exposures). This drug is a combination of an antipsychotic (flupentixol) and a tricyclic antidepressant (melitracen) and has the potential for severe toxicity in overdose. Regulatory bodies should evaluate whether evidence for its efficacy warrants its use considering its potential toxicity. In addition, the data include four exposures to elemental mercury from accidental exposure to the contents of a broken thermometer. The WHO considers mercury as one of the top 10 chemicals of major public health concern and recommends a phasing out of mercury-containing products in addition to developing a system for safe handling, use and disposal of remaining mercury-containing products [31].
A novel nonsense variation in the albumin gene (c.1309 A>T) causing analbuminaemia
Published in British Journal of Biomedical Science, 2021
G Caridi, A Farokhnia, F Lugani, AM de Luca, M Campagnoli, M Galliano, D Schröpfer, L Minchiotti
Subjects of this study are a 36-year-old male asylum seeker from Syria, brought to our attention by his older brother for a psychiatric consultation. Previous medical history was an acute psychiatric breakdown 3 years previously, treated with sertraline 50 mg, risperidone 0.5 mg and flupentixol/melitracen 0.5 mg/10 mg each once daily, with no other issues except a chronic fatigue. The brother denied that the patient had any history of unintentional weight loss, diarrhoea, or illness in the past. He also reported consanguinity of their parents (first-degree cousins) and the death of a sibling at the age of 4 months. He also reported that the case suffered from recurring infections of the respiratory tract and received regular inpatient treatments.