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Medication Errors
Published in Salvatore Volpe, Health Informatics, 2022
Jitendra Barmecha, Z. Last, A. Zaman
As technology continues to advance at unprecedented rates, it offers new options for expanding care and safety in medicine. There are many examples of technology being used to increase medication compliance, increase treatment efficacy, and decrease medication errors. Take, for instance, medication pill trays – normally you would think of a plastic container labeled morning and evening for Sunday through Saturday. In the market currently, you will find a wide range of “smart” pill organizers, or “smart packs,” which are electronic pill trays that can perform a wide range of tasks. Many of these pill trays can be paired with an app on your smartphone; depending on which type of smart pack you have, they can sound alarms during administration time, send notifications to you via text or email if a dose was missed, record whenever a medication was taken out, and give a reminder to the patient when the next dose is due or refill is required. Use of devices such as these can increase medication adherence rates and decrease omission.
Telehealth Comes of Age
Published in Tom Lawry, Hacking Healthcare, 2022
Improving self-administered medication compliance is one such area. From swallowing pills to injecting insulin, patients frequently administer their own medications. But they don't always get it right. Improper adherence to doctors' orders is commonplace. This lack of compliance accounts for thousands of deaths and billions of dollars in medical costs annually.10
Issues and Studies in Pharmacoeconomics
Published in Mickey C. Smith, E.M. (Mick) Kolassa, Walter Steven Pray, Government, Big Pharma, and the People, 2020
Mickey C. Smith, E.M. (Mick) Kolassa, Walter Steven Pray
Way back in its March 25, 1992 issue, the Wall Street Journal reported on the efforts of two pharmaceutical manufacturers (ICI Pharmaceuticals and Searle) to improve the compliance rates of patients taking some of the companies’ leading prescription products. Those efforts, which included such tactics as regular telephone calls to remind patients about refills, newsletters to users, and a toll-free number for patients’ inquiries, are costly, but the investment has an enormous potential for return to the manufacturer, as well as possible reductions in hospitalization cost as shown before. Improvement in medication compliance is definitely beneficial to everyone involved.
Complications after radiofrequency ablation of hyperparathyroidism secondary to chronic kidney disease
Published in Renal Failure, 2023
Li-Ping Lin, Miao Lin, Song-Song Wu, Wei-hua Liu, Li Zhang, Yi-ping Ruan, Mei-zhu Gao, Fu-Yuan Hong
Early-stage SHPT can be effectively treated by phosphorus binders, vitamin D analogs, and calcimimetics [4]. However, these treatments do not always provide adequate control of SHPT, particularly at the late stage. Poor medication compliance, drug resistance, and drug side effects make treatment less effective and more expensive. Parathyroidectomy (PTX) should be considered in patients with severe SHPT [5]. PTX can improve hypercalcemia, hyperphosphatemia, and tissue calcification and reduce the risks of cardiovascular events and overall mortality in dialysis patients. However, SHPT patients with serious comorbidities are at increased risk of anesthesia-related morbidity and mortality, being deemed not fit for surgery. Thus, thermal ablation can be introduced as an alternative therapeutic option for these patients [6]. In addition, RFA causes fewer complications, such as nerve damage, bleeding, infection, and fever, and reduces the duration of hospitalization [6,7].
Quality of clinical management of cardiometabolic risk factors in patients with severe mental illness in a specialist mental health care setting
Published in Nordic Journal of Psychiatry, 2022
Petter A. Ringen, Elisabeth Lund-Stenvold, Ole A. Andreassen, Torfinn L. Gaarden, Cecilie B. Hartberg, Erik Johnsen, Silje Myklatun, Kåre Osnes, Kirsten Sørensen, Kjetil Sørensen, Arne Vaaler, Serena Tonstad, John A. Engh, Anne Høye
Another notable finding was that prescription of the cardiometabolic risk associated antipsychotics clozapine and olanzapine reduced the chances for patients with obesity of getting motivational interventions for increased physical activity or receiving dietary advice. One potential explanation could be that patients on clozapine or olanzapine have more psychiatric symptoms, limiting the possibilities for active interventions, but symptom load did not act as a significant confounder in the analyses of the associations. It could still be that the type of medication may affect the clinicians’ interpretation. A focus on medication compliance could perhaps overshadow the follow-up of possible side effects. Another possibility is that prescription of these antipsychotics biases the clinicians’ attitudes towards thinking that weight reducing interventions may have lower efficacy. We also found that longer duration of treatment increased the chances of dietary advice for obesity. This may just be due to a high correlation between weight increase and duration of treatment, but if the findings indicate that dietary advice is not given in an early treatment phase it is problematic, as early interventions are crucial for prevention of risk factors.
Feasibility of developing hospital preparation by semisolid extrusion 3D printing: personalized amlodipine besylate chewable tablets
Published in Pharmaceutical Development and Technology, 2022
Xiaolu Han, Dongzhou Kang, Boshi Liu, Hui Zhang, Zengming Wang, Xiang Gao, Aiping Zheng
This study focused on laboratory research to explore the feasibility of SSE 3D printing hospital preparations. To address poor swallowing ability and pediatric patient compliance, we developed customized ‘cartoon’ amlodipine besylate (AMB) chewable tablets (may be chewed for ease of administration) for children aged 2‒16 years. Six strengths of 1.5‒5 mg were developed to meet the target children’s requirements. The appearance of the cartoon can not only effectively reduce wrong dose allocation but also improve willingness to take the medicine. As a model drug, AMB has a bitter taste, and improving the taste and establishing a taste evaluation system are also important considerations for children’s preparations. Our study explored the feasibility of commercial personalized 3D-printed tablets from the development of the 3D printing formulation and process, taste evaluation and scaling up of production, and ensuring acceptable shelf life and yield for children's hospital preparations. This technology can be used to improve pediatric medication compliance, provide new methods for the dose adjustment with narrow therapeutic windows using clinical blood concentration monitoring, and provide a basis for automated dose dispensing in the hospital.