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Heart Failure/Congestive Heart Failure
Published in Charles Theisler, Adjuvant Medical Care, 2023
In severe CHF, magnesium orotate (6,000 mg/day for one month, 3,000 mg/day for about 11 months) resulted in improvement in nearly 40% of patients. In patients who did not receive magnesium, 56% deteriorated. Overall, magnesium orotate increased the survival rate and improved clinical symptoms and patient’s quality of life.35
L-Threonic Acid Magnesium Salt Supplementation in ADHD: An Open-Label Pilot Study
Published in Journal of Dietary Supplements, 2021
Craig Surman, Carrie Vaudreuil, Heidi Boland, Lauren Rhodewalt, Maura DiSalvo, Joseph Biederman
Pilot studies have explored forms of magnesium supplementation in children with ADHD. For example, six months of treatment with magnesium preparations in daily doses of 200 mg/day was associated with reduction in hyperactivity in a study of 50 children with ADHD with documented deficiency of magnesium. In that study, there was an increase in the magnesium content in hair and a decrease of hyperactivity relative to a control group that did not receive magnesium (Starobrat-Hermelin and Kozielec 1997). Another open-label study evaluated the effects of 100 mg of a combined Mg(2+)/vitamin B6 regimen on the behavior of 52 “hyperexcitable” children under the age of 15. Thirty of the 52 hyperactive children had lower than expected erythrocyte Mg values. Combined Mg(2+)/vitamin B6 intake for 3 to 24 weeks restored expected erythrocyte Mg values, and variables of hyperexcitability were reduced after 1 to 6 months treatment (Mousain-Bosc et al. 2004). In a similar study, a magnesium-vitamin B6 (Mg-B6) regimen (6 mg/kg/d Mg, 0.6 mg/kg/d vit-B6) was given to 40 children with clinical symptoms of ADHD over 8 weeks. Over the study, measures of hyperactivity, hypermotivity/aggressiveness, and attention in school improved, while there was also a significant increase in erythrocyte Mg values. When the Mg-B6 treatment was stopped, ADHD symptoms reappeared within a few weeks, and erythrocyte Mg values decreased (Mousain-Bosc et al. 2006). As shown by Slutsky et al. (2010), oral delivery of LTAMS to rats achieves significantly higher levels of magnesium in cerebrospinal fluid than the control feed, whereas magnesium chloride, magnesium orotate, or magnesium gluconate did not. LTAMS, therefore, offers a novel mechanism of modulating brain function that could potentially lead to the alleviation of ADHD symptoms (Slutsky et al. 2010).