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Micronutrient Supplementation and Ergogenesis — Minerals
Published in Luke Bucci, Nutrients as Ergogenic Aids for Sports and Exercise, 2020
Guidelines for magnesium supplementation (when known to be depleted) are 100 to 250 mg/d of magnesium from magnesium lactate, magnesium gluconate, magnesium glycinate, magnesium taurate, or magnesium chloride.
Magnesium homeostasis
Published in Kupetsky A. Erine, Magnesium, 2019
Ravi Sunderkrishnan, Maria P. Martinez Cantarin
No trials exist to support an optimal regimen, but the general consensus is to administer 4–6 g of intravenous (IV) MgSO4 per day for 3–5 days to replete body stores after an initial loading dose of 1–2 g over 5–60 min, depending on symptoms. One gram of IV MgSO4 contains 100 mg elemental Mg. Since plasma magnesium levels do not reflect body magnesium stores, serial FeMg assessments during treatment may help determine the duration of IV replacement. Torsades de pointes is an emergency and should be treated with 1–2 g IV magnesium sulfate over 10 min independently of plasma magnesium. For oral magnesium replacement, 240–1000 mg of elemental magnesium is provided per day, divided into two to three doses. The most common magnesium preparations are magnesium oxide (400–600 mg BID-TID for 3–4 days to start) or magnesium gluconate (can be given 500–1000 mg TID). This may, however, be limited by side effects such as diarrhea. There are preparations of magnesium chloride (Slow-Mag) that are associated with fewer GI side effects due to a sustained-release formulation and that possibly lead to better magnesium absorption. Magnesium replacement should be used cautiously in patients with renal insufficiency. Chronic kidney disease (CKD) patients should be repleted at 50%–75% of the recommended dose.
Orthomolecular Parenteral Nutrition Therapy
Published in Aruna Bakhru, Nutrition and Integrative Medicine, 2018
Arturo O'Byrne-Navia, Arturo O'Byrne-De Valdenebro
We have used Mg intravenously as magnesium chloride 20% solution (HeilPro DKN, Cali, Colombia; Farmacia Milenium, Farmacia Francesa, Buenos Aires, Argentina) or magnesium sulfate 10% solution (Farmacia Milenium, Farmacia Francesa, Buenos Aires, Argentina). It is added to multiple mineral preparations, along with amino acids and antioxidants like DMSO. Our main experience has revolved around the utility of Mg as an aid in pain control, with interesting symptomatic results in bone, muscles, and joint complaints.
Givosiran, a novel treatment for acute hepatic porphyrias
Published in Expert Review of Precision Medicine and Drug Development, 2021
Manish Thapar, Sean Rudnick, Herbert L. Bonkovsky
Acute attacks of AHP are the most frequent and troubling aspects of these disorders and the events that require careful management, first and foremost. Most patients with known AHP and occasional or more frequent acute attacks (mainly women during their reproductive years) try first to treat themselves with extra rest, analgesics (many use narcotic analgesics for acute attacks and/or often chronically), and carbohydrate loading. Affected patients often need to miss work or other social obligations and take to bed when symptoms are moderate to severe. If, after several hours to a few days, they are not improving, especially if they have developed nausea and vomiting, patients will present to urgent care or emergency rooms for IV therapy, which should include at least 300 g/d dextrose and parenteral narcotics. Nausea is treated with ondansetron and/or promethazine or similar phenothiazine. Hyponatremia and hypomagnesemia are sometimes also present and require appropriate replacement therapy with sodium and magnesium chloride.
L-Threonic Acid Magnesium Salt Supplementation in ADHD: An Open-Label Pilot Study
Published in Journal of Dietary Supplements, 2021
Craig Surman, Carrie Vaudreuil, Heidi Boland, Lauren Rhodewalt, Maura DiSalvo, Joseph Biederman
In addition, the risk profile of magnesium supplementation is favorable relative to that of other pharmacological treatments currently available under FDA indication for Attention Deficit Hyperactivity Disorder. In a rat model, magnesium chloride at an intake of up to 2.5% of food resulted in no significant toxic effects (Takizawa et al. 2000). In addition, acute and chronic supplementation for hypomagnesemia has been well tolerated with a favorable safety profile (Fuentes et al. 2006; Mathers and Beckstrand 2009). Magnesium supplements, including LTAMS, are widely purchased and consumed. The most common side effect of magnesium supplementation may be diarrheic effects.
Relationship between short-term self-reported dietary magnesium intake and whole blood ionized magnesium (iMg2+) or serum magnesium (s-Mg) concentrations
Published in Annals of Medicine, 2023
Velarie Y. Ansu Baidoo, Krisha Thiagarajah, Carmen D. Tekwe, Taylor C. Wallace, Nana Gletsu-Miller
The objective of the current study was to assess associations among blood iMg2+, s-Mg and short-term self-reported dietary intake of magnesium. We used data from our pilot clinical trial [8] on the bioavailability of a magnesium chloride supplement, which included dietary and biochemical assessments of status at baseline. We hypothesized that compared to concentrations of s-Mg, concentrations of iMg2+ would better correlate with short-term self-reported dietary magnesium intakes.