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Vinca rosea (Madagascar Periwinkle) and Adhatoda vesica (Malabar Nut)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Rajib Hossain, Md Shahazul Islam, Dipta Dey, Muhammad Torequl Islam
In an experimental rat model, ethanol V. rosea flower extract was found to have therapeutic effects (Nayak and Pereira, 2006). The extract improves wound-healing, raises hydroxyproline levels, and has antimicrobial activity against P. aeruginosa and S. aureus. Furthermore, V. rosea extracts from the leaves, stems, flowers, and roots exhibit antibacterial action against E. coli, Streptococcus pyogenes, Streptococcus agalactiae, Salmonella typhi, and Aeromonas hydrophila (Muhammad et al., 2009). 2,3-dihydroxybenzoic acid, vincoside, and chlorogenic acid possess defensive mechanisms against fungal pathogens by blocking 1,3-β-glucan synthase enzyme (Moreno et al., 1994; Daneshtalab, 2008). Moreover, loganic acid also has antifungal properties (Huang et al., 2012).
Medicinal Plants of Mongolia
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Narantuya Samdan, Odonchimeg Batsukh
Chemical constituents: Acids: erythrocentauric, roburic, and oleanolic acids (Chen et al., 2005), loganic acid (Lin et al., 2004), 2-methoxyanofinic acid (Tan et al., 1996); flavonoids: homoorientin, saponaretin (Tikhonova et al., 1989); alkaloids: gentianine (Figure 1.34), genctianal (Zhong and Jin, 1988), gentianidine (Liang et al., 1964); secoridoids: gentiopicroside, swertiamarin, sweroside, 6′-O-β-D-glucosylgentiopicroside (Chen et al., 2005), 6′-O-β-D-glucosylsweroside, trifloroside rindoside; and other compounds: kurarinone, kushenol I, β-sitosterol, stigmasterol, daucosterol, β-sitosterol-3-O-gentiobioside, α-amyrin, oleanolic acid, isovitexin, gentiobiose, and methyl 2-hydroxy-3-(1β-D-glucopyranosyl)oxybenzoate (Tan et al., 1996).
Antioxidant and cytoprotective properties of loganic acid isolated from seeds of Strychnos potatorum L. against heavy metal induced toxicity in PBMC model
Published in Drug and Chemical Toxicology, 2022
Alagarsamy Abirami, Simran Sinsinwar, Perumal Rajalakshmi, Pemaiah Brindha, Yamajala B. R. D. Rajesh, Vellingiri Vadivel
Based on antioxidant potential, CF-7 was considered as the active fraction, which was transparent and waxy in nature (Figure 3(A)) and showed single spot in TLC with ethyl acetate/methanol (50/50 ratio) solvent combination (Figure 3(B)). This fraction was subjected to LC-MS/MS analysis and only one signal at a retention time 2.97 min was observed in liquid chromatogram with a molecular mass of 375.23 m/z (Figure 3(C,D)). The mass of parent ion (375.40 m/z) and daughter ion (213.20 m/z) were matched with mass bank data and identified as loganic acid (C16H24O10). Loganic acid belongs to groups of terpenes called iridoids. It is a precursor for production of major indole alkaloids in plants such as Strychnos nux-vomica (Guarnaccia et al. 1970, Zhang et al. 2003), Cornus mas (Sozanski et al. 2015) and Cantharanthus roseus (Guarnaccia et al. 1970). The structure of loganic acid was confirmed by 1 H and 13 C NMR spectra (Supplementary Figure S1 and S2). The proton and 13 C NMR spectra were compared with a previously reported spectrum of loganic acid, which was isolated from Cornelian cherry (Cornus mas) by Zhang et al. (2003).